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vhl

  • 网络希佩尔-林道病;希佩尔林道;肿瘤抑制基因;林道;基因
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  1. Conclusion Imaging techniques still play an important role in the evaluation and management of VHL disease .

    结论影像学检查在冯·希佩尔·林道病的诊治中仍起着极其重要的作用。

  2. Expression of VHL and HIF-1 α and its clinical significance in the lung cancer tissue

    肺癌组织中VHL和HIF-1α表达及其临床意义

  3. Objective To discuss imaging features of von Hippel-Lindau disease ( VHL disease ) .

    目的探讨vonHippel-Lindau病(VHL病)的影像学特征。

  4. Somatic mutations of VHL gene and HIF-1 α expression in primary renal clear cell carcinomas

    肾透明细胞癌中VHL基因突变与缺氧诱导因子-1α表达的研究

  5. The mutations of VHL gene were irrespective of the age and pathological grade and stage of patients .

    结论:国人非遗传性肾透明细胞癌中存在VHL基因的突变,且与患者年龄,肿瘤分期、分级无相关性。

  6. The detection of mutations in VHL gene from a single cell in a patient with von Hippel-Lindau disease

    单细胞水平检测vonHippel-Lindau病基因突变的实验研究

  7. Results Combining with the familial history , individual history , radiology and pathology , the diagnosis of VHL can be made .

    结果结合家族史、个人史、影像学检查以及手术病理证实其诊断。

  8. Role of hypoxia inducible factor-1 α and VHL in murine endochondral ossification

    低氧诱导因子-1α和VHL对小鼠软骨内成骨过程的调控机制

  9. The VHL gene may be useful as a marker gene for the diagnosis of RCC and as a target gene for molecular therapy .

    VHL基因可作为临床诊断指标,并可望成为肾透明细胞癌基因治疗的重要目的基因。

  10. Objective To evaluate the imaging manifestation of von Hippel Lindau ( VHL ) disease .

    目的评价冯·希佩尔·林道病的影像学表现。

  11. Mutation of VHL gene from tumor tissue was detected from tumor tissue by polymerase chain reaction ( PCR ) and direct sequencing .

    采用单链聚合酶链反应(PCR)和测序法检测肿瘤组织中VHL基因的突变情况。

  12. Analysis of biallelic inactivation of the von Hippel-Lindau tumor suppressor gene VHL in patients of renal cell carcinoma patient

    肾细胞癌患者抑癌基因VHL双等位基因失活的测定

  13. These mutations mainly occurred in the last one-third region of exon 1 , 2 and 3 of the VHL gene .

    这些突变主要发生在第1,2,3号外显子的后1/3区,其中6例缺失,2例插入,3例误义突变。

  14. Mutation and hypermethylation of VHL gene in angioreticuloma

    血管网织细胞瘤中VHL基因突变与异常甲基化检测

  15. [ Objective ] To explored the VHL gene mutation in HCC and its relations with VEGF , MVD and its clinic-pathological features .

    研究人肝细胞癌与VHL基因突变的关系以及VHL基因突变肝细胞癌与VEGF、血管密度(MVD)及临床病理特征之间的相互关系。

  16. Objective : This paper was designed to detect von Hippel Lindau ( VHL ) gene mutation in the paraffin embedded renal carcinoma specimens .

    目的:研究石蜡包埋肾肿瘤标本VHL基因突变情况。

  17. VHL disease ( von Hippel-Lindau disease ) is a kind of hereditary cancer syndrome associated with the mutation of VHL anti-oncogene .

    VHL病(vonHippel-Lindaudisease)是一种遗传性肿瘤综合征,由VHL抑癌基因突变引起。

  18. Results VHL gene mutation was detected in 10 ( 35.7 % ) CCRCC tumor samples . There was no mutation detected in all normal kidney tissues .

    结果远离肿瘤的正常肾组织中未检测到VHL基因的突变,10例(35·7%)癌组织标本中存在VHL基因的突变。

  19. Objective : To detect the expression of hypoxia-inducible factor 1 alpha ( HIF-1 α), p53 , PTEN and VHL in breast cancers and study their relationship .

    目的:研究乳腺癌组织中p53、PTEN、VHL、HIF-1α的表达及其相互关系,并探讨其意义。

  20. Conclusion VHL disease is a heritance family multi systems neoplasm syndrome . Familiarity with the imaging features of VHL will be helpful to the accurate diagnosis .

    结论VHL病为家族性遗传性多系统肿瘤综合征,熟悉其影像学表现有利于正确诊断。

  21. Conclusion VHL gene aberration is not only responsible for the pathogenesis of VHL disease , but also an important pathogenetic basis for sporadic ELST .

    结论VHL基因的异常导致其功能改变不但是VHL的致病原因,而且是散发性内淋巴囊瘤发病的重要的基因遗传学基础。

  22. Conclusion Biallelic inactivation of VHL gene occurs in RCC due to VHL mutation and LOH , and its frequency rate is37 % .

    结论肾细胞癌中存在由VHL基因突变和LOH导致的VHL双等位基因失活现象,VHL双等位基因失活发生率为37%。

  23. Objective To investigate the mutation of Von Hippel-Ldau ( VHL ) tumor suppressor gene in peatients with primary sporadic human renal cell carcinoma ( RCC ) .

    目的探讨国人原发性散发性肾透明细胞癌中VHL抑癌基因突变及其意义。

  24. Methods : The hypermethylation was examined by methyl sensitive restrictive DNA endoenzyme analysis in 34 cases of angioreticuloma and the VHL gene mutations detected by PCR SSCP analysis .

    方法:采用PCRSSCP法检测血管网织细胞瘤中VHL基因的突变率及甲基化,敏感限制性内切酶消化法检测血管网织细胞瘤中VHL基因的异常甲基化率。

  25. Conclusions The renal lesions in VHL disease include both cysts and carcinomas , which are often multifocal and bilateral . Almost all the tumors are of clear cell type with a low stage and grade .

    结论VHL病中肾脏损害包括肾癌及肾囊肿,常为双侧多发性,肿瘤为透明细胞癌且分级分期低。

  26. Conclusion LOH of VHL gene is an important genetic event in Chinese sporadic renal carcinoma , and the LOH frequency is 41.4 % . VHL LOH has no influence on stage and grade of RCC .

    结论在散发性肾癌中,VHL基因LOH是肿瘤发生的重要机理,其发生率达41.4%,VHL基因LOH与肾癌分期、分级无关。

  27. Results : The number of the cases of decannulation was 97 , from 8 days to 1 year after operation , 11 cases without decannulatin ( VHL 6 , HHL 2 and OHL 3 ) .

    结果术后拔管97例,拔管时间8d至1年,未拔管11例(垂直半喉6例,水平半喉2例,超半喉3例)。

  28. Insulin-like growth factor-I receptor ( IGF-IR ) which is one of RTK family member has an intimate relationship with genes such as VHL and TGF - β . Researches of IGF-IR inhibitors have made progress in other tumors .

    胰岛素样生长因子-1受体(insulin-likeGrowthFactor-Ireceptor,IGF-IR)作为RTK家族成员,其在肾癌中与VHL、TGF-β等基因关系密切,IGF-IR抑制剂在其它肿瘤治疗中已取得一定进展。