化学预防

[目的]探讨不同职业的人群，对结核菌素（PurifiedProteinDerivativeofTuberculin，PPD）皮肤试验的反应强度以及强阳性反应者采用异烟肼（INH）化学预防的效果。

Objective : To evaluate the response intensity of the different professional crowd to tuberculin ( Purified Protein Derivative of Tuberculin , PPD ) skin test , and the effect of isoniazid ( INH ) chemoprophylaxis to the strongly positive reactors .

吡喹酮对小鼠日本血吸虫感染化学预防作用的初步探讨

Preliminary Study of Chemoprophylaxis with Praziquantel in Schistosoma Japonicum Infection in mice

丹酚酸B对口腔癌的化学预防作用

Chemopreventive Effect of Salvianolic Acid B on Oral Carcinogenesis

结论丹酚酸B有望成为一种理想的口腔癌化学预防药物。

Conclusion Salvianolic acid B may be a promising chemopreventive agent for oral cancer .

暴露前的抗逆转录病毒化学预防是一种有前途的预防人类HIV感染的方法。

Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus ( HIV ) acquisition .

对非HIV感染者的结核病化学预防，RZ方案较H方案有增加发生严重不良反应的风险。

However , this regimen increases risk of severe adverse effects compared with isoniazid in HIV-uninfected persons .

羧乙基锗倍半氧化物（Ge-132）对黄曲霉毒素B1诱导肝癌的化学预防作用

Chemoprophylaxis effect of carboxyethylgermanium ( ge-132 ) on AFB1-induced hepato-carcinogenesis

这些结果证明BAX在人的皮肤癌的凋亡过程中明显作用和暗示它在癌的化学预防策略中的作用。

These results establish an unambiguous role for BAX in apoptotic processes in human epithelial cancers and may have implications for cancer chemoprevention strategies .

结论COX-2在口腔癌变过程中是一个早期事件，可能成为化学预防作用的重要靶点。

Conclusion COX-2 overexpression occurred in the early stage of oral carcinogenesis , it could be an important target for the chemical prevention and therapy .

本研究结果提示，VES可能为潜在的肿瘤化学预防/治疗剂。

It is implicated that VES may act as a potential chemopreventive / chemotherapeutic agent .

目的比较利福平吡嗪酰胺联用方案（RZ）与异烟肼方案（H）化学预防潜在结核感染的有效性和安全性。

Objective To evaluate the efficacy and safety of rifampicin plus pyrazinamide versus isoniazid for prevention of tuberculosis among persons with or without HIV-infection respectively .

OLT对AFB1致树鼩肝癌前病变的化学预防作用

Chemopreventive effect of oltipraz ( OLT ) on AFB1-induced precancerous changes in liver of tree shrews

其治疗胃癌癌前病变，发挥胃癌化学预防作用的机制可能与其抑制COX-2的催化活性，减少PGE2、VEGF的产生有关。

The mechanism of healing PLGC and chemical prophylaxis gastric cancer mechanism is possible suppressing COX-2 catalytic activity , then reduction production of PGE2 、 VEGF .

旨在进一步探讨VES抑制肿瘤细胞生长的机理及将其作为肿瘤化学预防剂和治疗剂的可行性。

This study suggested that VES is a potential growth inhibitor of human gastric carcinoma cells in vitro .

结论：ATRA可诱导A549细胞分化及凋亡，为临床应用ATRA化学预防肺癌提供理论依据。

Conclusion : ATRA could both induce differentiation and apoptosis of A549 cells . This observation may provide evidence for ATRA in chemoprevention of lung cancer .

目的：应用大鼠短期实验模型进行Ge-132对黄曲霉毒素B1（AFB1）诱癌的化学预防研究。

Objective : To determine the protective effect of Carboxyethylgermanium ( Ge-132 ) during AFB1-induced hepato-carcinogenesis for Wistar short term model experiments .

利用DMBA诱发的Sprague-Dawley大鼠乳腺癌模型，评价白藜芦醇的肿瘤化学预防作用。

We investigated the chemopreventive potential of resveratrol by testing it against mammary carcinogenesis induced by DMBA in female Sprague-Dawley rats .

结论：DHEA可保护DNA及胸腺细胞免受氧化损伤，这可能是其发挥癌化学预防作用、阻断突变、抗促癌过程及增强机体免疫功能的机理之一。

Conclusions : Protection of thymocytes and DNA from oxidative damage and inhibitory effect on apoptosis induced by H2O2 might be closely related to its mechanisms of anti mutation and immune enhancing activity of DHEA .

结论芳维A酸乙酯对ODC、PCNA的抑制作用是其预防小鼠乳头状瘤发生的重要机制，它具有肯定的癌化学预防作用。

Conclusion Arotinoid ethylester has an inhibitory effect on ODC and PCNA by which it inhibits skin papilloma in mouse . Arotinoid ethylester possesses the effect of cancer chemoprevention .

第三代维甲类化合物R8605的癌化学预防作用及其作用机理的研究

Cancer Chemopreventive Action and Its Mechanism of Action of a Third-Generation Retinoid R8605

本研究为PCNA、AgNORs、Bcl-2蛋白、Bax蛋白以及ras-p21蛋白等作为大肠癌人群化学预防研究的生物学标志物的可行性和有效性提供了依据。

The study provided evidence supporting that PCNA LI , AgNORs , Bcl 2 , Bax and ras p21 protein could be used as effective biomarkers for colorectal carcinogenesis in human chemopreventive trials .

应用天然或人工合成的化合物去阻断、逆转或预防侵袭性肿瘤的发生，即肿瘤的化学预防（Chemoprevention）。

The application of natural or synthetic compounds to block , reverse or prevent the occurrence of invasive tumors , as known as chemoprevention , is an effective strategy .

AFB的适应证包括隐性肺癌的定位诊断、同期癌变组织的探查、评估局部癌变的程度、化学预防的研究等。

The applications of AFB include localization of roentgenographically occult lung cancer , detection of synchronous tumors , estimation of the extent of field cancerization , chemoprevention studies , etc.

目的通过测定小鼠二阶段皮肤乳头状瘤模型中鸟氨酸脱羧酶（ODC）、增殖细胞核抗原（PCNA）的变化，探讨芳维A酸乙酯的癌化学预防作用机制。

Objective To study the mechanism of arotinoid ethylester on cancer chemoprevention by assaying ornithine decarboxylase ( ODC ) activity and proliferative cell nuclear antigen ( PCNA ) index of mouse skin in the process of mouse papilloma formation .

R8605是我所在系统寻找癌化学预防药研究中研制的第三代维甲类化合物。

It belongs to the third-generation compound of retinoids and was found during the systematic screening of chemopreventive agents in our Institute .

这为白血病的化学预防和临床辅助治疗提供一定的理论依据。预防组和对照纽人群均随访三年，观察结核病的患病情况和INH的化学预防效果。

These results might be valuable both in chemoprevention and in clinical treatment of leukemia . The two groups were followed up three years , and observed the incidence state of tuberculosis and the chemoprophylaxis of INH .

结论VES对PC3细胞及其CAM移植瘤具有抑制肿瘤细胞增殖、促进细胞凋亡，阻滞细胞周期（G0/G1期）进展等作用，对前列腺癌具有潜在的化学预防作用。

Conclusion The possible mechanisms of VES inhibitory effect on the prostate cancer include the cell cycle G_0 / G_1 arrest , anti-proliferation and apoptosis induction . It suggests that VES has potential chemical prevention effect on the prostate cancer .

提示肿瘤微环境中的DJ-1蛋白可以作为化学预防治疗癌症的靶点，化学预防可以在早期对致癌因素进行控制，通过对微环境中多种细胞及细胞因子的干预而影响肿瘤表型。

Tumor microenvironment suggest DJ-1 protein can serve as a target for cancer chemoprevention , Chemoprevention against cancer-causing factors in the early control , micro-environment through a variety of cells and cytokines affect tumor phenotype intervention .

说明9201是有效的癌化学预防化合物。9201对环磷酰胺（CTX）引起的小鼠骨髓嗜多染红细胞微核形成有明显抑制作用。

It was demonstrated that 9201 is a potent cancer chemopreventive agent in vitro as well as in vivo.9201 exhibited a significantly inhibitory effect on cyclophosphamide ( CTX ) & induced micronucleus formation of polychromatic erythrocytes ( PCE ) of bone marrow in mice .

结论选择性COX2抑制剂尼美舒利能有效抑制ENNG诱导的大鼠胃癌及癌前状态的发生，这为COX2抑制剂对人类胃癌有潜在化学预防作用提供了证据。

Conclusions The selective COX-2 inhibitor nimesulide can significantly inhibit development of gastric cancer and precancerous changes induced by ENNG in model of rat . This provides evidence that COX-2 inhibitors may have chemopreventive potential in human gastric cancer .