吡硫醇

吡硫醇对脑缺血鼠脑内TXA2、PGI2、LPO的影响

Effect of Pyritinol on the Levels of TXA_2 , PGI_2 and LPO in Gerbil Brain Subjected to Ischemia

在沙鼠大脑缺血和再灌注模型上，观察TXA2、PGI2和LPO的含量变化及吡硫醇的影响作用。

In the model of ischemia and postischemic reperfusion of Gerbil cerebrum , the changes of the levels of TXA2 , PGI2 and LPo and the effect of pyritinol were observed .

HPLC法测定注射用盐酸吡硫醇中有关物质的含量

Determination of related substances in pyritinol hydrochloride for injection by HPLC

光谱法研究Cu（Ⅱ）-核固红-盐酸吡硫醇体系及其分析应用

Spectroscopic Study on the System of Cu (ⅱ) - Nuclear fast Red-Pyritinol Hydrochloride and Its Analytical Application

结果在选定的色谱条件下，20min内注射用盐酸吡硫醇中有关物质与盐酸吡硫醇能较好的分离。

Results Under the optimal conditions , a good separation was achieved for pyritinol hydrochloride and its related substances .

盐酸吡硫醇（PyritinolHydrochloride，Py-Hy）的基本结构为两个VB6分子以二硫键相联，但其没有VB6样作用或抗VB6样的作用。

Pyritinol Hydrochloride ( Py-Hy ) has two molecules of VB_6 which connected by disulfide bridge Although its chemical structure is similar to that of VB_6 ; Py-Hy does not have the effects of vitamins or antivitamins .

目的讨论合成盐酸吡硫醇的关键反应。

Objective To discuss the key synthesis reaction of Pyritinol Hydrochloride .

吡硫醇治疗颅脑损伤和脑瘤32例

Treatment of severe injury and tumour of brain with pyritinol injection in 32 patients

1,2-萘醌-4-磺酸钠测定盐酸吡硫醇的研究

Study on determination of pyritinol hydrochloride using 1,2-naphthoquinone-4-sulfonate

方法利用二价金属离子对盐酸吡硫醇结构的掩蔽作用，制成无痛型注射液。

Methods Metal ions of two adicity were utilized as masking agent for the development of less-painful formulations .

工业烷烃磺酸盐-利用直接两相滴定法测定烷烃磺酸盐含量的1,2-萘醌-4-磺酸钠测定盐酸吡硫醇的研究

Technical alkane sulfonates - determination of alkane monosulfonates content by direct two-phase titration Study on determination of pyritinol hydrochloride using 1,2-naphthoquinone-4-sulfonate

讨论了脑组织在缺血和再灌注时病理生理改变和吡硫醇发挥脑保护作用的机制。

We discussed the mechanism of pathophysiological changes of brain subjected to ischemia and postischemic reperfusion and the protective effect of pyritinol .

结论二价金属离子Ca2+和Mg2+均对盐酸吡硫醇中巯基起掩蔽作用，可降低盐酸吡硫醇的刺激性。

Conclusions Metal ion of two adicity have masking action to the thiol group of pyritinol hydrochloride and the formulations can reduce the irritation of PH.