吲哚美辛

吲哚美辛和美洛昔康对脂多糖诱导的小鼠腹腔巨噬细胞NF-κB的抑制作用

Inhibitory effects of indomethacin and meloxicam on nf - κ b in mouse peritoneal macrophages

吲哚美辛对COPD营养不良模型大鼠骨骼肌蛋白质分解代谢的影响

Influence of Indomethacin on Skeletal Muscle Protein Catabolism in COPD Malnutrition Rats

二氢卟吩P6-6-（N-乙基）酰胺-7，γ-二甲酯锌的合成及对吲哚美辛诱发大鼠胃溃疡的保护作用

Synthesis and protective effect of zinc chlorin P_6-6-N-ethylamide-7 , γ - dimethylester on indomethacin-induced gastric ulcer in rats

建立吲哚美辛片剂HPLC含量测定方法。

A HPLC method for the determination of Indometacin tablets was established .

结果：吲哚美辛诱导野生型p53转染的wtp53/SW480细胞凋亡，出现形态学改变：即细胞核固缩、裂解，核碎片及凋亡小体形成。

RESULTS : Indomethacin induced apoptosis in wtp53 / SW480 cells .

目的：探讨吲哚美辛抗结肠癌作用是否呈p53依赖性及其部分分子机制。

AIM : To investigate the anti - tumor effect of indomethacin on colon cancer .

实验组均给予吲哚美辛0.02g/100g体重灌胃，每日2次，共2d，制作胃肠黏膜损伤模型，对照组给予等量生理盐水。

Rat model with gastrointestinal mucosal injury was established by intragastric indomethacin twice a day for 2 days .

2组作随机单盲对照试验。结果：吲哚美辛组止痛作用优于曲马多组，总有效率分别为92.5%和82%（P＜0.05）。

RESULTS : The pain_relief effective rate in indometacin group was 92.5 % , higher than that ( 82 % ) of tramadol group ( P < 0.05 ) .

吲哚美辛、组胺&吲哚美辛对鼠Lewis肺癌凋亡诱导作用的实验研究

Experimental Study of the Apoptosis Inducing Effect of Histamin-Indomethacin on Lewis Lung Cancer in Mice

βcatenin→cMyc信号转导途径受抑与吲哚美辛的抗白血病效应存在一定的联系。

Anti-leukemia effect of indomethacin was associated with the inhibition of "β - catenin → c-myc " signal pathway .

结论：吲哚美辛能抑制人喉癌Hep-2细胞系的侵袭性。

CONCLUSION : Indomethacin can inhibit the invasion of Hep-2 cells .

吲哚美辛对阻塞性黄疸病人外周血淋巴细胞IL-10、IL-2活性的影响

Effects of indometacin on activity of IL-10 and IL-2 in human peripheral lymphocytes of patients with obstructive jaundice

作为非特异性抗炎药物的吲哚美辛，有抑制炎症反应的作用，但是否能改善SAP大鼠的预后很值得探索。

We want to find whether there is an effect of simultaneous treatment with Gln and indomethacin on rats with SAP .

吲哚美辛促使Hep-2细胞形态良性转化，可能促进细胞的分化。

Indomethacin might have the effect of induced-differentiation on Hep-2 cell line .

吲哚美辛对喉癌Hep-2细胞iNOS和COX-2基因表达的影响

Study of Gene Expression of Indomethacin on iNOS and COX-2 in Human Laryngeal Cancer Cells Hep-2

目的观察幽门螺杆菌（Hp）与吲哚美辛分别或同时作用的情况下，对Balb/c小鼠胃粘膜损伤的程度有无差异，并探讨两者间是否存在相互作用。

Objective To investigate the interaction of Helicobacter pylori ( Hp ) and indomethacin in gastric mucosa injury of Balb / c mice .

吲哚美辛诱导HL-60细胞凋亡过程中伴有β-catenin/c-myc信号转导途径的抑制

Indomethacin-induced HL-60 cell apoptosis is associated with inhibition of β - catenin / c-myc signal transduction pathway

在加入一种中和性的抗IL-6抗体或者前列腺素E2抑制剂吲哚美辛后，T细胞活性部分恢复。

The T-cell activation is partially restored upon addition of a neutralizing anti-IL-6 antibody or the prostaglandin E2 inhibitor indomethacin .

结果：吲哚美辛组和地塞米松组，停药后显效率分别为97%和50%，（P＜0.01）。

RESULTS : The excellent response rate was 97 % ( 31 / 32 ) in indometacin group and 50 % ( 15 / 30 ) in dexamethasone group , ( P < 0.01 ) .

HPLC法测定壮骨活血丸中吲哚美辛的含量活血化淤补肾壮骨中药促进山羊下颌骨牵张成骨的实验研究

Determination of Indomethacin content in Zhuanggu Huoxue Pills with HPLC method A primary experimental study on the effects of Chinese tradition medicine on accelerating mandibular distraction osteogenesis

目的：探讨吲哚美辛对急性颅脑损伤颅内压（ICP）的影响。

AIM : To study the effect of indometacin on intracranial pressure ( ICP ) in patients with acute brain injury .

体内建立裸鼠皮下移植瘤模型，喂服吲哚美辛3mg/（kg·d）共4周，隔日测瘤结节体积及鼠重，评价吲哚美辛的抑瘤效果。

Transplanted tumor models were established with BALB / c nude mice and were treated with indomethacin at 3 mg / ( kg · d ) for 4 weeks .

吲哚美辛对人喉癌Hep-2细胞系的生长及侵袭作用的研究

Effect of indomethacin on the growth and invasion of Hep-2 cells in human laryngeal cancer

结论：吲哚美辛所致大鼠胃粘膜损伤具有昼夜节律，并且与PGE2、SOD、MDA的昼夜变化有关。

Conclusions : Gastric vulnerability to Indomethacin injury exhibited circadian rhythmicity , and correlated with circadian variation of PGE2 、 SOD 、 MDA .

方法：以吲哚美辛（消炎痛）复制大鼠NSAIDs性胃粘膜损伤模型，以光镜和扫描电镜观察粘膜损伤状况；

Methods : NSAIDs induced gastric mucosal damage model in rats was obtained by indomethacin .

目的探讨口服吲哚美辛治疗足月儿动脉导管未闭（PDA）的疗效。

Objective To explore therapeutic effect and side effect of oral indomethacin for treating patent ductus arteriosus ( PDA ) in full-term infants .

目的：研究吲哚美辛胃损伤中内皮素（ET）、一氧化氮（NO）、氧自由基的作用，以及胃动力对这种损伤的影响。

Purpose : To study the role of endothelin ( ET ), nitric oxide ( NO ), oxygen free radicals and gastric motility in the indomethacin-induced gastric mucosal injury .

吲哚美辛对大鼠脊髓损伤后TXA2/PGI2代谢的影响

The effects of indomethacin on thromboxane A2 / Prostacyclin ratio after spinal cord injury in rats

目的探讨吲哚美辛（IN）抗慢性髓系白血病（CML）细胞增殖的作用机制。

Objective To explore the mechanism of anti proliferative effect of indomethacin ( IN ) on chronic myelogenous leukemia ( CML ) cells .

用微观放射自显影技术及免疫组化法探讨了非甾体类抗炎药吲哚美辛（IN）对Lewis肺癌的生长抑制作用机制。

Micro autoradiography and immunohistochemistry techniques are used to study one of non-steroidal anti-inflammatory drugs & indomethacin ( IN ) 's growth-inhibition mechanism towards rats ' Lewis pulmonary tumor .