多拉菌素

同时，研究了多拉菌素的发酵代谢曲线，发酵液的pH、总糖含量、还原糖含量、氨基氮含量、菌体浓度的代谢变化。

At the same time , researched the metabolic curve of doramectin in the fermentation , excluded the variational of pH value , total sugar , deoxidize sugar , amino nitrogen and packed cell volume .

多拉菌素的突变生物合成及发酵条件优化

The Mutational Biosynthesis of Doramectin and Studies on the Fermentation Condition

结果显示，各试验组药物对猪血虱都有明显的驱杀作用，其中多拉菌素高、中剂量组药物残效期达120d以上。

The results showed that it was effective in all drug groups , protection period of residue drug both the high and middle level groups after injecting doramectin was up to 120 days .

多拉菌素对沙皮犬蠕形螨病的疗效观察斯坦尼斯拉斯·蒙盖拉

Therapeutic and persistent efficacy of doramectin against demodex canis in Shar-Pei

大鼠及小白鼠口服多拉菌素的急性毒性试验

Acute toxic trial of doramectin after orally administered to mice and rat

多拉菌素是新一代大环内酯类抗生素，属于阿维菌素第三代衍生物。

Doramectin is a new generation of macrocyclic lactones antibiotics , belonging to third - generation derivatives of avermectin .

运用该系统对几个除虫链霉菌工业生产菌株的次生代谢途径和代谢流向进行了改良，首次获得了遗传改造的可以产生多拉菌素的基因工程菌株。

An unprecedented genetic modified strain can produced Doramectin was obtained through secondary metabolism engineering and metabolic flux improvement with this system .

多拉菌素为20世纪90年代研制开发出的新一代大环内酯类抗寄生虫药，是被认为目前阿维菌素类药物中最优秀的药物之一。

Doramectin , developed as a new generation of macrolide antiparasitic drugs in the nineties of the 20th century . It is considered one of the best drugs in the present avermectins .

采用递增法预试测得大鼠和小白鼠口服多拉菌素LD0值依次为5.37g/kg。

With the method of increase by degrees , LD_0 and LD_ ( 100 ) of doramectin were detected after orally administered to mice and rat.LD_0 in turn is 5.37 g / kg .