突触前抑制

已知GABA作用于初级感觉神经元能引起初级传入去极化，因而实验结果提示，咖啡因有可能在初级传入末梢产生对抗突触前抑制的效应。

Because GABA can induce primary afferent depolarization ( PAD ), our results suggest that caffeine may be able to antagonize the effect of presynaptic inhibition of GABA in primary afferent .

由观察DRP的结果提示，在PAG对脊髓伤害感受神经元的下行抑制作用中，可能有突触前抑制参与。

This study suggests that the descending inhibitory system from PAG may involve presynaptic inhibition in the effect of PAG on the WDR and NS neurons .

本文首次报道豚鼠心肌存在一种新型突触前抑制性受体&－组胺H3受体。

This is the first time to report the existence of new presynaptic inhibitory autoreceptors-histamine H3 - receptors in guinea pig myocardium .

以上结果表明，NT可通过轴轴突触和/或非突触性轴轴接触的一级传入C纤维的传入进行突触前抑制。

These results indicate that NT may presynaptically inhibit the transmission of primary afferent C fibers Via axoaxonic synapses and / or nonsynaptic contacts .

幼年大鼠大脑皮质5&HT（1B）受体中介的突触前抑制

5 - ht_ ( 1b ) receptor mediated presynaptic inhibition in neonatal rat cortex

阿片肽在后角镇痛的作用机理，被认为是通过突触前抑制一级传入纤维P物质释放的结果，然而始终未获得形态学的证实。

It has been suggested that the analgesic effect of opioid peptides in the dorsal horn is mediated by presynaptic mechanism to inhibit the release of substance P. However , ultrastructural data indicated that axo-axonal synapses between enkephalin and substance P terminals are unlikely .

目的：观察大鼠脊髓后角浅层内δ阿片受体是否存在于初级传入C纤维内，为脑啡肽在痛觉初级传入调制中的突触前抑制机制提供更为可靠的形态学依据。

Objective : To provide morphological evidence for presynaptic inhibition mechanism of enkephalin in modulating primary input of pain by observing whether ? opioid receptor in the superficial layers of the rat spinal cord is located in the primary afferent C fiber or not .

CCK-8S是目前发现最强的内源性抗阿片物质。阿片肽可增强γ-氨基丁酸（GABA）介导的突触前抑制的作用，而CCK-8S可对抗阿片肽的这一作用。

CCK-8S is one of the strongest endogenous anti-opioid substances and suppresses opioid peptides-mediated ' pre-synaptic inhibition ' of γ - aminobutyric acid ( GABA ) release .

延髓后角脑啡肽超微结构定位和非突触部位释放&脑啡肽突触前抑制痛觉传递的形态学基础

Ultrastructural localization and nonsynaptic release of enkephalin in the medullary dorsal horn

本工作为突触前抑制理论与针刺镇痛原理的研究提供了新资料。

Our work has provided some new information for further investigating presynaptic inhibition and mechanism of acupuncture analgesia .

鉴于一级传入纤维存在大量阿片受体的事实，曾提出阿片肽突触前抑制可能是通过非突触的轴-轴作用。

In fact , a high density of opioid receptors are present on primary sensory fibers in this region .

结论：突触前抑制下降、脊神经后根传入纤维侧支出芽、突触再建在脑瘫肌痉挛形成中起了重要的作用；

Conclusions : The decrease of presynaptic inhibition and formation of new synapses by sprouting of afferent axon terminals probably play a role in spasticity of cerebral palsy .

另外，由于神经元之间存在大量的特殊的耦合结构，例如突触前抑制、突触前易化以及侧抑制结构等，这些复杂的联结结构也会使得神经元的峰电位的振幅发生变化。

Besides , there are a large number of special coupling structures , such as presynaptic inhibition 、 presynaptic facility and lateral inhibition , etc. These complicated synaptic configurations can change the amplitude of neuronal spiking .

上述结果表明；视叶能以突触前抑制的形式参与躯体感觉传入的离心控制，影响脊髓反射活动，并可能涉及镇痛机制。

Thus , the results indicate that the optic tectum takes part in the centrifugal control of somatosensory afferent activity , affects the spinal reflex , and involves in the mechanism of analgesia by way of presynaptic inhibition .

背根神经节小型神经元初级传入末梢上的GABAB受体在脊髓背角接受中间神经元的突触前抑制，是脊髓水平痛觉调节的途径之一。

The metabotropic type-B γ - aminobutyric acid receptors ( GABABR ) on the central teminals of the small sized dorsal root ganglion ( DRG ) neurons play an important role in pain regulation by presynaptic mechanism at spinal level .

吗啡通过突触前机制抑制视上核神经元兴奋性突触传递

Presynaptic inhibitory action of morphine on excitatory synaptic transmission in rat SON neurons in brain slices