自噬体

后进一步用该细胞模型验证自噬体在结核分枝杆菌感染中的作用。

After using the cell model to further verify the autophagosome in Mycobacterium tuberculosis Infection .

自噬体是一种吞入细胞器、细胞质的双层膜结构，它与溶酶体融合形成自噬溶酶体。

Autophagosome is a double-membraned structure that swallows organelles and cytoplasm and fuses with lysosomes to form autolysosome .

形态学研究结果表明，岩藻多糖硫酸酯作用于Hela细胞还可以导致自噬体的形成，这是自噬的一个典型的特征。

In addition , the morphological study indicated a characteristic finding of autophagy , such as the formation of autophagosomes in fucoidan-treated Hela cells .

结果：KA所引起的凋亡条带呈剂量依赖性趋势，透射电镜显示大鼠纹状体KA注射1小时后即可见纹状体神经元内自噬体形成，8小时后自噬体出现最明显；

Results : Internucleosomal DNA fragmentation occurred in the KA-injected ( 1.25-5.0 nmol ) striatum in a dose-dependent fashion . Electron microscopy revealed that the formation of autophagosomes in the ipsilateral striatum started 1 hour and reached maximum 8 hours after injection of KA .

自噬体&溶酶体系统与2型糖尿病关系的研究

Study on Relationship between Type 2 Diabetes Mellitus and Autophagic-Lysosomal System

本文主要对自噬体的发生过程、分子机制和信号调控等方面进行概述，以期较为全面地了解细胞自噬作用和最新研究动态的相关资料。

This paper has mainly reviewed the genesis , molecule mechanism and signal control in order to understand autophagy and the up-to-date research information .

她的第一批实验小鼠细胞内的自噬体为被标记成了荧光绿色，自噬体是由包绕着待循环再利用的细胞成分所构成。

Her first batch of rodents were tweaked so that their autophagosomes - structures that form around components which have been marked for recycling-glowed green .

在溶酶体酶的作用下，自噬体吞入的细胞成分被降解，该过程具有清除受损细胞器及异常蛋白质的重要作用。

The cellular components swallowed by autophagosome were degraded by the lysosomal enzyme . This process has an important role in the removal of damaged organelles and abnormal proteins .

如果说锻炼促进了小白鼠自噬体的增加，那么为了找出原因，研究团队对另一种小白鼠进行了试验，但没能收到相同的效果。

To find out what , if anything , this exercise-boosted autophagy was doing for mice , the team engineered a second strain that was unable to respond this way .

结果显示：溶酶体系统由有衣小泡、致密体、多泡体、消化泡、自噬体和残体组成；

The results showed that the lysosomal system was mainly made up of small coated vesicles , dense bodies , multivesicular bodies , autophagic vacuoles , digestive vacuoles and residue bodies .

主要是突触小泡明显减少，长管形泡较多，髓膜样或自噬体样结构经常可见等变化。

The main changes included an obvious decrease in synaptic vesicle number and an increase in elongated vesicle number , In addition , myeloid body or phagosome-like structure can be seen more frequently .

之后，小白鼠们放在跑步机上进行了半小时的锻炼，她发现小鼠肌肉内的自噬体增多了，跑到80分钟后这中增长就停止了。

After these mice had spent half an hour on a treadmill , she found that the number of autophagosomes in their muscles had increased , and it went on increasing until they had been running for 80 minutes .

在本文中，我们讨论了那些与细胞自噬以及蛋白酶体系统相关联的分子机制，并讨论了在选择性自噬作用中，泛素与泛素结合蛋白的新兴作用。

Here , we discuss the molecular mechanisms that link autophagy and the proteasome system , as well as the emerging roles of ubiquitin and ubiquitin-binding proteins in selective autophagy .

真核细胞使用自噬和泛素蛋白酶体系统，作为它们主要的蛋白质降解通道。

Eukaryotic cells use autophagy and the ubiquitin-proteasome system as their major protein degradation pathways .

在锰诱导的自噬水平改变的过程中，自噬体生成的增多而非溶酶体降解功能的下降发挥了主要的作用。

The enhanced autophagy was mainly due to the increased autophagic vacuole generation rather than the repression of lysosomal degradative function . 3 .

溶酶体失活使自噬过程无法完成，导致细胞内自噬体显著增加囤积。

Lysosomal inactivation makes the autophagy process interrupted , resulted in a significant increasing of autophagic accumulation in cellular .

在自噬过程中，一部分细胞质被双层膜结构包裹形成自噬体，然后靶向运输到液泡，被液泡内水解酶降解。

During autophagy , portions of cytoplasm are sequestered into a double-membrane autophagosome and delivered to vacuole for breakdown .

自噬又称为二型细胞死亡（typeⅡCellDeath），是细胞程序性死亡的一种，其特征是自噬体的聚集。

Autophagy also known as type II cell death , is a kind of programmed cell death , which is characterized in autophagosome aggregation .

自噬也称为Ⅱ型程序性细胞死亡，在这一过程中，细胞浆中的大分子物质和细胞器被包裹形成自噬体，随后与溶酶体融合并对自噬体内容物成分进行降解。

Autophagy is a Type ⅱ programmed ceil death . In this process , the cellular components are sequestered in an autophagosome and , subsequently , the autophagosome fuses with a lysosome to degrade those contents .