金刚烷胺

本文讨论了1-溴代金刚烷的合成，为工业化生产金刚烷胺盐酸盐提供了资料和数据。

The paper discusses the synthesis of1-bromoadamantane , providing materials and data for the industrial production of adamantanamine hydrochloride .

C组用金刚烷胺+安乃近治疗；

Amantadine and analgin were together applied in Group C ;

结论：NAM体外毒性和抗病毒活性均优于阳性对照金刚烷胺；

Conclusion NAM has better antivirus activity and lower toxicity , compared with amantadine in vitro .

目的评定单用金刚烷胺、金刚烷胺与复方丹参或丙炔苯丙胺合用对早期帕金森病（PD）患者治疗的效果和安全性。非诺贝特单独治疗引起横纹肌溶解症临床分析（附3例报告）

Objective To assess the clinical efficacy and safety of amantadine monotherapy and concomitant amantadine with salvia miltiorrhiza compound or selegiline of the treatment of Parkinson 's disease .

与病毒模型组相比，金刚烷胺组、中药高中低各剂量组的肺指数降低，均有显著性差异P0.05，中药各组的剂量与肺指数呈负相关、与肺抑制率呈正相关。

Compared with the model group , the lung exponent of amantadine group and traditional Chinese medicine low / medium / high dose group all reduced which have significant difference ( P0.05 ) .

因为H1N1病毒对金刚烷胺及金刚烷乙胺具有耐药性，所以禁止对疑似感染H1N1病毒的患者使用这类药物。

Novel H1N1 seems to be resistant to amantadine and rimantadine , so these drugs should not be used in people with suspected novel H1N1 infection .

各亚群病毒具有各自的基因特征，SX亚群病毒获得了抗金刚烷胺的耐药性。

Different clades possess their own property of genome . SX clade acquired the resistance to amantadine and antigenic-drifted .

通过调节超支化聚酰胺胺末端金刚烷胺的封端率，该超支化聚合物的LCST可以实现在较宽温度范围内的调控。

By adjusting the ADA-capped ratio , the LCST of the hyperbranched polymer can be successfully regulated in a wide temperature range .

PPD患者普遍对安坦和金刚烷胺敏感，较少出现左旋多巴制剂所致的运动障碍、开关现象和剂末恶化。

The patients with PPD are usually sensitive to artane and to amantadine hydrochloride . Levodopa or levodopa preparations-induced movement disorders , on-off phenomenon and end of dose deterioration occur less in the patients with PPD .

方法：采用双相滴定法，测定金刚烷胺合剂中盐酸金刚烷胺的含量。

Methods : The diphasic titration was used in the test .

金刚烷胺修饰物抗禽流感病毒的作用机制

Mechanism of modified amantadine against influenza A ( H5N1 ) virus

双相滴定法测定金刚烷胺合剂的含量

Quantitative determination of amantadine in amantadine mixture by diphasic titration

金刚烷胺和金刚乙胺两种药物，从这个阶层。

Amantadine and Rimantadine are two drugs from this class .

流感病毒性肺炎及金刚烷胺药物防治的实验病理学研究

Pathological Study of Influenza Virus Pneumonia in Mice and Prophylaxis-Treatment by Using Amantadine

病毒感染早期使用达菲有效，但对金刚烷胺和金刚乙胺有抗药性。

Early use of Tamiflu infection effective , but Amantadine and rimantadine resistant .

金刚烷胺是一种抗病毒药，主要抑制A型流感病毒的复制。

Amantadine is an antiviral agent which specifically inhibits influenza group A virus replication .

目的观察硫酸金刚烷胺注射液对实验动物的神经和心血管系统的影响。

Objective To investigate the effects of Amantadine sulfate to nerve and cardiovascular systems .

硫酸金刚烷胺与盐酸金刚烷胺对流感病毒的作用比较

Inhibited effect of Amantadine sulfate compared with Amantadine hydrochloride to influenza A virus in vitro

该新病毒对奥司他韦和扎那米韦较敏感，但对金刚烷胺和金刚乙胺具有抗药性。

The virus is sensitive to oseltamivir and zanamivir , but resistant to amantadine and rimantadine .

金刚烷胺修饰物对禽流感病毒感染小鼠免疫功能的影响

Effect of modified amantadine on immune function of mice infected with influenza A ( H5N1 ) virus

猪流感病毒株已经被美国和墨西哥拿来测试，结果显示这种病毒对而耐金刚烷胺和金刚乙胺有抗药性。

The virus isolates that have been tested from the US and Mexico are however resistant to amantadine and rimantadine .

金刚烷胺治疗吉兰-巴雷综合征患者的疲劳：一项随机、双盲、安慰剂对照的交叉试验

Amantadine for treatment of fatigue in Guillain-Barr é syndrome : A randomised , double blind , placebo controlled , crossover trial

这些分析表明，土耳其的病毒对包括奥司他韦和金刚烷胺在内的这两类抗病毒药物敏感。

These analyses indicate that the Turkish viruses are sensitive to both classes of antiviral drugs , including oseltamivir and amantadine .

对老药金刚烷胺，金刚乙胺的抗药性已经非常普遍，已经不建议使用这些药物了。

Resistance to the older drugs , amantadine and rimantadine , is now so widespread that their use is no longer recommended .

金刚烷胺是一个脂肪族三环伯胺，主要以原形经肾排泄，在体内只经历有限的代谢。

Amantadine is an aliphatic tricyclic primary amine , which is excreted predominantly unchanged into the urine and undergoes limited metabolism in man .

选用黄芪、板蓝根、射干等二十种中草药和金刚烷胺、中性丫啶黄两种西药为试验药物进行体外抗病毒试验。

Twenty Chinese herbs such as Radix Astragali , Radix isatidis and rhizome belamcandae , and amantadine and neutral acriflavine were used in anti-virus experiment in vitro .

这四种药品对大部-猪流感病毒都有效，但最近从人类分-出来的猪流感病毒对金刚烷胺和金刚-乙胺有抗药性。

There are four different antiviral drugs that are licensed for use in the US for the treatment of influenza : amantadine , rimantadine , oseltamivir and zanamivir .

这种药物有两类：1）烷胺类药物（金刚烷胺和金刚乙胺），2）流感的神经氨酸酶抑制剂（奥司他韦和扎那米韦）。

There are two classes of such medicines , 1 ) adamantanes ( amantadine and remantadine ), and2 ) inhibitors of influenza neuraminidase ( oseltamivir and zanamivir ) .

第三部分，建立了禽畜肉中抗病毒类药物的定量检测平台，包括禽肉中金刚烷胺残留量的测定及禽畜肉中利巴韦林残留量的测定。

In the third chapter , a platform for detecting antiviral drugs in livestock and poultry meats was established , including the determination of amantadine in poultry meats and the determination of ribavirin in poultry and livestock meats .

金刚烷胺制药废水具有可生化性差、难降解、成分复杂、无机离子含量高等特点，废水中所含的金刚烷胺笼状结构大大增加了废水处理的难度。

Wastewater generated during amantadine production is a kind of pharmaceutical wastewater with poor biodegradability , complicated components , and high concentration of inorganic ions . There are a large amount of amantadine structure-containing organic matters in the wastewater , which makes the wastewater very hard to be treated .