印记基因

对与小鼠胚胎发育相关的印记基因Mcts2的研究

A Study on a New Imprinted Gene in Mouse Embryonic Development

植物广泛地使用这些表观沉默机制来控制发育及亲本来源的印记基因表达。

Plants use these epigenetic silencing mechanisms extensively to control development and parent-of-origin imprinted gene expression .

体细胞核移植牛肺脏中印记基因的DNA甲基化状态分析

DNA Methylation Status of Imprinting Genes in Lungs of Somatic Cell Nuclear Transfer Bovines

现在普遍认为DNA的甲基化的功能是参与许多印记基因、失活的X染色体上的基因、转座子和内源的反转录病毒的沉默。

It is believed that DNA methylation has important functions in gene imprinting , for transposons and in vivo retrovirus silencing as well as the stability of the genome ;

探索遗传稳定性及印记基因甲基化异常与NTDs发生的可能联系。

To explore the connection between the genetic stability , abnormal methylation of imprinted genes and NTDs . Methods : 1 .

目的检测韦伯综合征（BeckwithWiedemannsyndrome，BWS）相关印记基因在人类卵母细胞和植入前胚胎的正常表达，探讨辅助生殖技术（assistedreproductivetechnology，ART）和BWS的关系。

Objective To investigate the expression of imprinted genes related to Beckwith-Wiedemann syndrome ( BWS ) in human oocytes and preimplantation embryos for understanding the relationship between assisted reproductive technology ( ART ) and BWS .

提取实验组和对照组睾丸RNA，采用上海生物芯片中心小鼠寡核苷酸基因表达谱芯片筛选表达发生改变的印记基因，对感兴趣的基因经半定量RTPCR验证。

Testis RNA from irradiated and control mice was extracted , the imprinted genes expressing variably were screened with mouse oligo gene expression chip supplied by Shanghai Biochip Center and the interested genes were verified by semiquantitative RT-PCR .

PEG1在人和鼠上均为母系印记基因。

The gene PEG1 was imprinted in human and mouse .

目的探讨印记基因H19在自然流产者绒毛组织中的表达及意义。

Objective To investigate the expression of H19 imprinted genes in the villus tissues of women with spontaneous abortion .

印记基因是基因组中一小部分亲本来源特异性沉默的基因。

Imprinted genes are a small proportion of genes on the genome showing parent-of-origin-specific silencing .

哺乳动物印记基因的研究进展

Progress on Imprinted Genes in Mammals

遗传印记基因影响哺乳动物细胞的生长、发育和行为，与人类先天性疾病、发育不全和肿瘤等密切相关。

Genetic imprinting genes affect mammalian cell growth , development and behavior , and closely relate to human genetic diseases , hypoplasia and tumors .

印记基因对哺乳动物胎儿的发育具有十分重要的作用，对个体的生长与行为也有一定影响，特别是对胎盘发育极为重要。

Many imprinted genes are involved in fetal development , and may influence fetal growth and behavior . Imprinting appears to be particularly important for placental development .

胎盘是影响猪胎儿发育的重要组织，也是印记基因发挥调控最重要的组织之一。

The placenta is the important organization affecting pigs fetal development , and also is one of the most important organization which imprinted genes can regulate on .

目前，已经在小鼠中鉴定出的印记基因数量超过100个，其中多数基因是母本表达，少数为父本表达。

Up to now , more than 100 imprinted genes have been identified in mouse . Most of them are expressed from the maternal allele and the others from the paternal allele .

这说明，印记基因的表达模式在染色质上确实有所表征，这种表征（特定的染色质结构）很可能就是印记基因的细胞记忆标记。

It was concluded that the expressed pattern of imprinted genes marked / imprinted on the chromatin strictly , which ( specific chromatic structure ) may be the mark for cell memory .

克隆猪中印记基因表达量均与正常猪存在差异，但由于个体差异，印记基因表达量的差异不显著。

All expression level of imprinted gene in cloned pigs have difference from normal pigs . However , due to individual differences , the difference of expression of imprinted genes were not significantly .

印记基因的存在能导致细胞中两个等位基因的一个表达而另一个不表达。

The presence of imprinted gene can cause cells with a full parental complement of functional autosomal genes to specifically express one allele but not the other , resulting in monoallelic expression of imprinted loci .

而克隆动物除了本身供体细胞重编程的异常会导致发育失败，其体外操作过程和培养条件都会对发育造成影响，出现这些异常的主要原因就是印记基因表达调控受到影响而紊乱。

Except for somatic cell reprogramming developmental failure could cause abnormalities of cloned animals , the in vitro procedure and culture conditions also impact on development . And cause these abnormality have been appearanced mostly because all imprinted genes have been damaged , and could not be expressed normally .

组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；

The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing , X inactivation and genomic imprinting .

Kono领导的团队推测：带有父亲印记的基因可能对男性有特别自由的控制，从而使之短寿、早逝。

Paternally imprinted genes may have particularly free rein in males , Kono 's team reasoned , and may govern traits such as living fast and dying young .

哺乳动物的基因组印记与印记基因疾病

Genetic Imprinting and Disease of Mammals

基因组印记（又称遗传印记）是指基因根据亲代的不同而有不同的表达。

Genomic imprinting ( genetic imprinting ) refers to parent of origin dependent gene expression .

阐述了基因组印记的可能机制及一些最新定位的印记基因，并论述了基因组印记在发育生物学、遗传学和物种进化研究中的生物学意义。

It covers data on mechanisms of gene imprinting , several imprinted genes that were recently identified and the biological significance of genome imprint in development , genetics and Darwinian evolution .

综述基因组印记的可能发生机制及人和鼠中常见的印记基因。

This article reviews the mechanisms of genomic imprinting and several commonly imprinted genes in human and mouse .