发作性睡病

发作性睡病的临床、电生理特点及其与HLA的关系

The clinical , electrophysiological characteristics and HLA typing of narcolepsy in Chinese

目的：探讨发作性睡病的临床特征及多次小睡潜伏期试验（MSLT）在诊断发作性睡病中的作用。

Objective : To probe clinical characteristics of narcolepsy and the role of multiple sleep latency test ( MSLT ) in the diagnosis of narcolepsy .

最后，用定量实时PCR法在一组新样本（20名发作性睡病-猝倒患者和20名健康对照）中进一步确认候选基因的表达水平。

Finally , the expression levels of the candidate genes were further confirmed by quantitative real-time PCR using a new set of samples ( 20 narcolepsy-cataplexy patients and20 healthy controls ) .

下丘泌素（OREXIN）缺乏可预测发作性睡病猝倒患者严重的白天睡眠过多

Hypocretin ( orexin ) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy

方法对35例发作性睡病（NC）和30例嗜睡症（IH）进行整夜多导睡眠图（PSG）描记和多次睡眠潜伏期试验（MSLT），分析其睡眠参数异同。

Methods Whole-night PSG and MSLT were conducted in 35 patients with NC and 30 with IH and sleep parameters analyzed .

目的观察氟西汀（即百优解，fluoxetine）对发作性睡病（narcolepsy）猝倒（cataplexy）发作的治疗效果并探讨其剂量选择。

Objective To evaluate fluoxetine and its effective dosage in the treatment of cataplexy in narcolepsy patients .

目的探讨发作性睡病（NRL）儿童的抑郁情绪及事件相关电位P300的特征。

Objective To explore the clinical value of depression and event related potentials P300 in children with narcolepsy ( NRL ) .

初步的研究显示，组胺H3受体拮抗剂可引起觉醒。因此，H3受体拮抗剂在应用于发作性睡病方面受到人们的关注。

Histamine H3 receptor antagonists are getting attention in the treatment of narcolepsy for the fact that H3 receptor antagonists can induce wakefulness .

方法对12例正常人、17例发作性睡病及12例阻塞性睡眠呼吸暂停综合征（OSAS）患者进行MSLT检查。

Methods 12 control , 17 narcoleptic and 12 obstructive sleep apnea syndrome ( OSAS ) subjects were examined with MSLT , which consisted of 30 minute .

目前还需要进一步的研究去发现MX2与发作性睡病在病理生理机制方面的功能联系。

Further studies are required to explore the functional relationship between the MX2 gene and narcolepsy pathophysiology .

目的：探讨多次睡眠潜伏期试验（MSLT）对发作性睡病的诊断价值。

Aim : To explore value of the multiple sleep latency test ( MSLT ) for the diagnosis of the patients with narcolepsy .

结论：MSLT对发作性睡病、阻塞性睡眠呼吸暂停、原发性嗜睡症和睡眠中周期性腿动等疾病的诊断和鉴别诊断具有重要参考价值。

Conclusion : The MSLT might be of important value in diagnosis and differential diagnosis of narcolepsy and OSAS and Idiopathic lethargy and periodical leg movement .

以睡眠潜伏期≤5min诊断发作性睡病，其两次小睡的灵敏性91.67%～100%，特异性85.71%～95.24%；

If the SLT < 5 minutes was applied to the diagnosis of the narcolepsy , the sensitivity of two times sleep was 91.67 % ~ 100 % .

结论：我们发现发作性睡病患者与正常人相比，其白细胞MX2基因表达明显下降。

We found the MX2 gene to be significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients .

发作性睡病的临床特征及多次小睡潜伏期试验

Clinical features and multiple sleep latency test in patients with narcolepsy

目的探讨发作性睡病的证候学特点及证类分布特征。

Objective To analyze the characteristics of TCM syndromes of narcolepsy .

发作性睡病录像脑电图监测

Monitoring on the video electroencephalogram of patient with narcolepsy

目的了解发作性睡病患者夜间睡眠结构特点。

Objective To study the characteristics of nocturnal sleep architecture in narcoleptic patients .

88例发作性睡病患者的证候学分析

Analysis on TCM Syndromes of 88 Cases of Narcolepsy

人类发作性睡病中大脑皮质机能的受累

Functional involvement of cerebral cortex in human narcolepsy

早发型发作性睡病的临床特点

Clinical features of early - onset narcolepsy

本研究旨在明确发作性睡病患者血细胞异常背后的基因表达变化。

We attempted to identify alterations in gene expression underlying the abnormalities in the blood cells of narcoleptic patients .

损毁下丘脑某些区域以致食欲肽神经元胞体减少，则可引起睡眠-觉醒功能障碍（如原发发作性睡病等）。

If hypothalamus in some areas is destroyed and orexin neurons are reduced , sleep-awakening dysfunction will appear ( for instance : narcolepsy ) .

发作性睡病病人在入睡或苏醒过程中可能出现睡眠性麻痹，发作时病人头脑清醒，但在短时间内会完全不能活动。

Sleep paralysis , normal when falling asleep or waking , occurs during full consciousness in narcolepsy , with brief but complete inability to move .

结果共检出9例发作性睡病，在实验检查人群中的患病率是1.8%。

Results : There were 9 narcoleptic patients documented resulting in an overall laboratory prevalence of 1.8 % or 2.45 % of patients presenting with hypersomnia .

方法随机选择入组之前6个月内未接受任何针对性治疗的发作性睡病患者30例。

Methods 30 narcolepsy subjects with cataplexy who had no direct or specific treatment since 6 months were admitted to the department for fluoxetine treatment efficacy studies .

由于脑成像的方法，评价睡眠失调对于失眠、呼吸暂停综合征、抑郁或发作性睡病患者的神经影响，也是可能的。

Using a brain imaging approach , it will now be possible to assess the neuronal impact of sleep disturbances in patients with insomnia , apnea syndrome , depression or narcolepsy .

与对照组受试者睡眠生理参数相比，差异具有显著性意义（P<0.05或P<0.01）。结论发作性睡病患者夜间睡眠结构的特征为快速眼动活动增强，睡眠维持机制紊乱，中枢唤醒水平降低。

Compared to the control group the difference of sleep physiological parameters was significant ( P < 0.05 or P < 0.01 ), Conclusion The nocturnal sleep architecture of narcoleptic patients is characterized with increasing REM activities , disturbing sleep maintenance and lowering central arousal levels .