头孢噻肟酸

在最佳反应条件下（催化剂用量、反应物用量、结晶pH已经优化）头孢噻肟酸的合成摩尔收率超过98%。

Under the optimum conditions ( catalyst amount used , reactant amount used , crystal pH already optimized ) we got over 98 % yield in cefotaxime acid synthesis .

在线红外检测仪在头孢噻肟酸合成中的应用

The Apply of On-line Infrared Detector in the Synthesis of Cefotaxime acid

头孢噻肟酸合成母液回收工艺的研究

Research on process of recovery of mother-liquid in synthesis of Cefotaxime

头孢噻肟酸合成新方法研究

A New Study on the Synthesis of Cefotaxime Acid

部份降解的头孢噻肟酸转钠结晶工艺

Recovering Cefotaxime Sodium From Partial Degradation Cefotaxime

方法以头孢噻肟酸为原料，采用正交试验法确定头孢噻肟成钠盐的最佳反应温度、成钠剂、有机溶媒；

METHODS The optimum reactive temperature , sodium donor , organic solvent of cefotaxime formed sodium salt in technics was confirmed by orthogonal test method with cefotaxime as raw material ;

用头孢噻肟，头孢噻肟/克拉维酸、头孢他啶，头孢他啶/克拉维酸这两对纸片同时进行筛检超广谱β-内酰胺酶，可有效降低ESBLs漏检率。

Using both CTX , CTX / Clavulanic acid and CAZ , CAZ / Clavulanic acid simultaneously can reduce the missing rate of ESBLs .

结论以头孢噻肟，头孢噻肟/克拉维酸这对纸片可达到有效进行CTX-M酶的表型检测的目的；

Conclusions The phenotypic confirmatory tests for CTX-M enzymes can be detected only by CTX and CTX / Clavulanic acid effectively .

结果头孢噻肟钠收率达93%（以头孢噻肟酸计），成品质量稳定且符合中国药典2000年版二部标准规定。结论本小试工艺合理，适合于进一步扩大中试生产。

RESULTS The yield of cefotaxime sodium obtained 93 % . ( accounted with cefotaxime ), and the product quality accorded with the standard of CP edition 2000.CONCLUSION This diminutive test technics is rationalized , adapt to enlarge medium test production .

研究了以二甲基乙酰胺（DMA）为催化剂，7-氨基头孢烷酸（7-ACA）与苯并噻唑活性酯（MEAM）为原料，一步合成头孢噻肟酸的实验过程。

The experimental process on synthesis of cefotaxime acid was studied by using 7 aminocephalosporanic acid ( 7 ACA ) and MEAM as raw material under the catalytic action of DMA .

7-氨基头孢烷酸和2-甲氧亚氨基-2-（2-氨基-4-噻唑基）-（z）-硫代乙酸苯胼噻唑酯（AE活性酯）发生酰化反应生成头孢噻肟酸，收率90%。

Cefotaxime acid was synthesized by 7-ACA and AE active ester , the yield was 90 % .