心气虚证

SD大鼠心气虚证模型的研制及其实验质量控制

To Establish Model of Heart-Qi Deficiency Syndrome in SD Rat and Study It 's Control of Quality

心气虚证复合因素造模法对Wistar大鼠基因表达的影响

Influence on Gene Expression Due to Replicate Heart-Qi Deficiency Syndrome on Wistar Rat Caused by Complex Factor

心气虚证心肌细胞模型β受体、ET和NOS基因表达的改变

Changes of β - receptor , et and NOS genes expression in cardiac muscle cell with deficiency of heart qi syndrome

结论心气虚证的分子基因水平的病理生理学基础与β1受体、ET和NOS基因表达有关。

Conclusion : The pathophysiological base of DHQS molecular genetics was related to β - receptor , ET and NOS genes expression .

心气虚证组、兼阴虚证组与兼血瘀证组的T4水平较兼水肿血瘀证组均明显升高（P<005，P<001，P<001）；

Level of T 4 in other three Syndrome groups significantly increased than that in the edema and blood stasis Syndrome type .

结合挖掘结果，运用网络结构可视化思想构建心气虚证网络结构图，并运用逆转录聚合酶链反应（RT-PCR）探索心气虚证基因网络结构。

To integrate the results of clustering data mining and based on visual model requirement , network structure diagram of HQDS would be drawn , gene network structure be study with RT-PCR .

心气虚证动物模型的诊断标准为：外观有虚证的表现，心功能降低，cAMP降低，SOD降低，MDA升高，免疫功能低下，心气虚较重者可伴有ANP的升高。

The diagnosis standard of animal model of heart-qi deficiency syndrome is : deficiency appearance , depressed heart function , decreased cAMP and SOD , increased MDA and restrained immune function . ANP could increase in serious case .

目的：进一步研究冠心病（CHD）心气虚患者与心室舒张收缩功能的相关性，为CHD心气虚证的中医辨证提供客观及微观辨证指标。

Objective : To explore the correlations between heart qi deficiency syndrome of TCM and ventricular systolic and diastolic function of CHD patients , providing some objective and microcosmic indexes for syndrome differentiating of heart qi deficiency in CHD patients .

血浆ET水平依次为心血瘀证>心阴虚证、心气虚证>正常对照组（P<0.01，P<0.05）。

The ET level was higher in the syndrome of heart blood stasis than that in the syndrome of heart yin deficiency , higher in the syndrome of heart qi deficiency than that in the normal group ( P < 0 . 01 or P < 0 . 05 ) .

目的：建立WKY大鼠心气虚证动物模型。方法：造模组实验全过程控食，按5%体重负重强迫游泳至力竭，持续16天。

Objecive : To establish heart-qi deficiency syndrome model in WKY rat . Methods : Every animal in experiment group was forced to load-carrying swim under 5 % body weight with slimming until exhausted every day for 16 days .

强迫跑步法建立昆明种小鼠心气虚证模型

Creation of Deficiency Syndromes of Heart mouse model with forced running

目的：探索心气虚证动物模型的制作方法。

To probe the methods of inducing the animal model of heart qi deficiency .

人参注射液对冠心病心绞痛心气虚证作用的临床研究

Clinical Study on Ginseng Injection for Patients with Deficiency of Heart-Qi Syndrome of Angina

心气虚证大鼠模型心功能变化的超声评价

Echocardiography evaluation about the heart function change on rat models of heart-Qi deficiency syndrome

心气虚证动物模型雌二醇睾酮变化的实验研究

Experimental Research on the Changes of Sex Hormones in the Animal Models of Heart Qi Deficiency

人参注射液治疗冠心病心气虚证与心阴虚证的临床研究

Clinical Study on Treatment of Heart-Qi Deficiency and Heart-Yin Deficiency in Coronary Disease with Ginseng Injection

目的：为监测心气虚证患者病情变化寻找一项客观指标。

Objective : To seek an index for observing the changing of the Heart-Qi Dificiency Syndrome ( HQDS ) .

基因芯片结果提示，血管内皮损伤是导致心气虚证的重要发病机理。

The results of gene chip suggest that damage of vascular endothelium is a main mechanism resulting in heart - qi deficiency syndrome .

心气虚证大鼠循环肾素血管紧张素系统激活与血浆纤溶酶原激活物抑制剂活性变化的实验研究

Qi Deficiency and Blood Stasis and Circulatory Renin-Angiotensin System as well as Plasminogen Activator Inhibitor Activity in Rats with Cardiac Qi Deficiency Syndrome

目的观察、探讨人参注射液对冠心病心绞痛心气虚证的疗效及作用机理。

To investigate the therapeutic effect of Ginseng injection ( GI ) for deficiency of heart-qi syndrome of angina and its mechanism of actions .

8中药治疗心气虚证的机理可能与心气虚证的基因网络调控有关，单味益气中药疗效优于单味补血和活血药，益气活血复方效果优于单味中药。

The mechanism of herbs function is relate to the gene network regulation of HQDS , the Xin-fu-kang recipe have better effect than single herb .

结论：采用基础进食量、电刺激强迫跑步及大剂量灌服心得安的综合方法建立心气虚证动物模型是可行的。

Conclusions : It is feasible to establish HQD animal model by using complex factors including forced running with eletricity stimulation and ig large dosage of propanolol .

目的：研究冠心病心气虚证与左心室功能和心肌供血三者的相关性。

Objective : To study the relationship among Heart-Qi Deficiency ( HQD ), left ventricular function and myocardial ischemia in patients with coronary heart disease ( CHD ) .

方法：本研究运用数据挖掘技术，对心气虚证古代文献资料、临床信息和科研进展等方面的数据进行聚类挖掘，发掘心气虚证辨证论治规律的新知识或被忽视的内容。

Method : The investigation clustering the ancient literature , clinical Information and scientific research about HQDS by clustering data mining for find out some new or neglected knowledge .

结论：心肌缺血和血瘀可造成心气虚证，补气治疗心气虚证又可反作用于血瘀证，使心肌缺血好转。

Conclusions : Myocardial ischemia and blood stasis cause HQD , while the Chinese herbal medicine treatment on HQD could improve the blood stasis to alleviate myocardial ischemia effectively .

结论经过合理的实验质量控制，采用力竭运动结合控食及大剂量灌服心得安的综合方法，建立心气虚证动物模型是可行的。

Coclusion By controling the experimental quality , it is feasible to establish the model of HQDS in SD rat by adopting the method of exhausted exercise with slimming and large dosage of propanolol .