慢性暴露

目的观察小鼠慢性暴露于卷烟水溶性提取物（CSE）能否引起心肌毒性，并明确烟气中的尼古丁是否会引起心肌损伤的毒性成分。

Objective To determine whether chronic exposure to cigarette smoke extract ( CES ) in mice could induce myocardium toxicity and to clarify whether nicotine in cigarette smoke is responsible for this impaired myocardium response .

方法：测定通过口服途径亚慢性暴露于百草枯、MPTP或等量生理盐水的小鼠脑内线粒体呼吸链中复合酶Ⅰ、Ⅱ、Ⅳ及柠檬酸合成酶的活性。

Methods : Activities of complex ⅰ, complex ⅱ, complex ⅳ and citrate synthase were measured after mice exposed to paraquat or MPTP or the same amount normal saline administered orally every day for 2 months .

锌对铅亚慢性暴露小鼠脑铅含量的影响

Effects of Zinc on Lead Content of Brain in Mice with Lead Sub-Chronic Exposure

镉亚慢性暴露对小鼠性腺影响的研究

Influence on sexual glands of mice under low doses and subchronic administration of cadmium

小鼠慢性暴露于百草枯对其脑线粒体呼吸链复合酶活性的影响

The Influence of Paraquat on Cerebral Mitochondrial Respiratory Chain Activity After Mice Exposed to Paraquat by Oral Administration

目的探讨镧亚慢性暴露对大鼠外周血常规检查指标的影响。

Objective To explore the effect of lanthanum subchronic exposure on peripheral blood cells index in rat models .

研究母鼠有机磷农药敌百虫低剂量亚慢性暴露，对着床前期胚胎细胞遗传学和生长发育的影响。

We assessed cytogenetic and developmental toxicity in pre-implantation mouse embryos after maternal exposure to trichlorfon at low doses for one month .

结果无毛鼠耳部和背部皮肤在紫外线慢性暴露下，表皮组织中免疫递呈细胞&郎格罕细胞数显著减少，脾脏T细胞增殖功能明显下降，提示紫外线可抑制细胞免疫。

Result After exposure to UV the number of immune presentation cell-LC in epidermis and proliferating function of spleen T cell of the hairless mouse were all declined significantly , UV could inhibit cellular immunity .

慢性铝暴露使ERK的蛋白表达显著降低。

Chronic Aluminum Exposure enabled ERK protein expression to decrease significantly .

脑发育不同阶段慢性铅暴露对大鼠在体海马齿状回LTP的影响

Effect of chronic lead exposure at brain different developmental stages

慢性次声暴露对豚鼠听觉传出通路CGRP免疫反应的影响

Influences of infrasound on the distributions of CGRP IR in the efferent auditory pathways in guinea pigs

母体慢性铝暴露对子代鼠海马LTP的损害作用

Impairment of Maternal Chronic Aluminum Exposure on Hippocampal LTP of Offspring in Rats

慢性氨气暴露对肉鸡NK细胞杀伤活性和血清新城疫抗体效价和溶菌酶的影响

Effects of Chronic Ammonia Exposure on Natural Killer Cell Activity , Newcastle Disease Antibody Titer and Serum Lysozyme Levels of Broiler

慢性铝暴露对大鼠海马突触可塑性LTP影响及其机制研究

Effects and Mechanism of Chronic Exposure of Aluminum on Rats Hippocampus Synapse Plastic LTP

慢性铝暴露，导致LTP增加的PS（群体锋电位）幅值比率逐渐下降。

Chronic aluminum exposure caused the increased PS ( population spike ) amplitude LTP ratio decline gradually . 3 .

方法用RT-PCR法检测慢性铅暴露时小鼠海马bcl-2和BAXmRNA表达水平。

Methods RT-PCR techniques were applied to recognize either the mRNA expression of bcl-2 and bax in hippocampus of mice exposed to low level of lead .

慢性缺氧暴露后线粒体RNA和蛋白质合成活性分别为对照的72%和76%；

But in chronic hypoxic exposure , the inhibition of both RNA synthesis and protein synthesis was alleviated , being 72 % and 76 % of the normoxic control , respectively .

文献报道，急、慢性砷暴露可以抑制大鼠海马LTP的诱导和维持。

Literatures have reported that acute and chronic arsenic exposure can significantly inhibit the induction and maintenance of LTP .

目的：探讨母体慢性铅暴露对子代鼠在体海马齿状回长时程增强（long-termpotentiation，LTP）的影响。

Objective : Our purpose was to investigate the effects of chronic lead exposure of mother rat on long term potentiation ( LTP ) in vivo of their offsprings .

结论急、慢性镉暴露均引起NK细胞活性下调，富硒乳酸菌能有效地对镉造成的机体损伤有保护作用，调节和改善NK细胞活性。

Conclusion Acute and chronic cadmium exposure induced downregulation of NK cell activity . Se-enriched lactobacillus could protect effectively the injury induced by cadmium , and adjusted and ameliorated NK cell activity .

亚慢性砷暴露对小鼠脑组织线粒体Sdha表达影响

Subchronic Exposure to Arsenic Decreased Sdha Expression in the Brain of Mice

目的通过观察不同浓度慢性铝暴露对海马长时程增强（long-termpotentiation，LTP）的影响，检测海马细胞内Ca2+浓度和蛋白激酶C（PKC）生物活性，研究慢性铝暴露损伤学习记忆的机制。

Objective To go deep into the mechanism of chronically aluminum-induced impairments to memory through observing the effects of chronic aluminum exposure on long-term potentiation ( LTP ) and studying the changes of Ca2 + concentration in hippocampus and protein kinase C.

本文观测了慢性氨暴露对中华鳖（Pelodiscussinensis）幼鳖血浆总氨氮、皮质酮浓度及与氨代谢有关的酶活性的影响。

The present study investigated the influence of chronic ammonia exposure on plasma total ammonia-nitrogen ( TAN ), corticosterone concentration and activities of enzymes involved in ammonia metabolism of juvenile soft-shelled turtle Pelodiscus sinensis .

结论慢性铝暴露引起大鼠海马细胞内[Ca2+]i下降，使PKC活性降低，导致下游分子的活性受到影响，破坏LTP的形成，损害学习记忆功能。

Conclusion Chronic aluminium exposure can decline the concentration of calcium in hippocampus and reduce the activity of PKC , thus affect the activity of its downstream kinases , damaging the formation of LTP and consequently impairing the ability of learning and memory .

急、慢性铅暴露引起仔鼠海马NMDAR亚单位、[Ca～（2+）]i、凋亡的变化与学习记忆损伤的关系

Changes of Hippocampal NMDAR Subunit 、 [ Ca ~( 2 + ) ] _i 、 Apoptosis Induced by Acute or Chronic Lead Exposure and Relationship with Impairment of Learning and Memory in Pups of Mice

短期及亚慢性锰暴露均可影响大鼠的学习能力，其记忆功能的改变仅出现在亚慢性的锰暴露。PAS-Na治疗或预防均可拮抗锰暴露所致的学习及记忆功能改变。

The prevention of PAS-Na in organ quality changed caused by manganese exposure is good . ( 3 ) Short-term and subchronic manganese exposure all could affect the rat learning ability , and the memory fuction change only appeares in the long term period of manganese exposure .

慢性铅暴露小鼠海马细胞凋亡相关基因的表达

Expression of apoptosis-related gene in hippocampus of mice after chronic lead exposure

对氨基水杨酸钠对亚慢性铅暴露大鼠海马超微结构的影响

Effects of sodium para-aminosalicylic acid on hippocampal ultramicro-structure of subchronic lead-exposed rats

目的探讨亚慢性镉暴露对雄性大鼠生殖系统的毒作用。

Objective To explore the effects of subchronic cadmium exposure on male sexual systems .

慢性汞暴露大鼠肾小球的透射电镜研究

The transmission electron microscope study on the glomerules of rats exposed to mercury chronically