戊脉安

戊脉安对体外培养肿瘤细胞集落形成率及DNA合成的影响

Effect of verapamil on colony formation and DNA synthesis of tumor cells in vitro

本文采用体外培养的L（1210）细胞株，研究了戊脉安的体外抗肿瘤作用。

The effect of verapamil on L_ ( 1210 ) leukemia cells in vitro were studied .

在P（388）及HEP-3细胞中双层琼脂或普通平皿法测定的克隆形成细胞活存率实验也证实了戊脉安有相同的增效作用。

Clonogenic cell survival assay in P_ ( 388 ) and HEP-3 cells treated by AMSA alone or in combination with VER revealed similar enhancement effect of VER on AMSA cytotoxicity .

发现戊脉安对L1210细胞的生长有一定的抑制作用，且呈剂量相关，并能显著降低L1210细胞的分裂指数。

The results showed that verapamil had certain dose-related inhibitory effects on the growth of L_ ( 1210 ) cells and the mitotic index of L_ ( 1210 ) cells .

戊脉安可能造成心脏充血并停跳。

Verapamil can cause congestive heart failure .

结果表明：戊脉安无论是胃内给药还是肌内注射，均能明显地降低胃粘膜损伤，起到保护作用。

The results showed that the treatment with verapamil before ischemia produced significant protection against gastric injury in rats induced by ischemiareperfusion .

DMT1.5μM也可使由低Ca~（++）或戊脉安所引起的离体豚鼠左房肌减弱的收缩力增强。

DMT 1.5 nM also increased the contractile force of isolated guinea pig left atria exposed to low concentration of calcium or to verapamil .

在戊脉安和心得安所致大鼠心衰模型上，多巴胺2mg/kgiv的心血管效应与心脉龙相似。

On a rat model of verapamil and propranolol-induced heart failure dopamine 2 mg / Kg iv showed cardiovascular effects , which is similar to complex nucleosides .