橙皮素

柚皮素和橙皮素对重组人肌醇磷脂3-激酶p110β催化亚基的影响

Effect of naringenin and hesperetin on recombinant human phosphoinositide 3-kinase p110 β catalytic subunit

目的：研究柚皮素和橙皮素对重组人肌醇磷脂3-激酶（PI3-K）p110β催化亚基酶活性的影响。

Objective : To study the effect of naringenin and hesperetin on activity of recombinant human phosphoinositide 3-kinase ( PI3-K ) p110 β catalytic subunit .

目的：橙皮素（Hesperetin）柑桔属中存在的一类天然类黄酮化合物，具有抗炎症，抗氧化，抗变态反应，保护心血管和抗肿瘤等药效作用。

Objective : Hesperetin which is a kind of natural flavonoid compounds insists in citrus , it has many pesticide effect such as anti-inflammatory , oxidation resistance , resistance to allergy , protect the cardiovascular and antitumor . And its Mainly comes from the hydrolysis of orange peel glucoside .

东莨菪亭与橙皮素联用对小鼠抗炎作用的定量分析

Quantitative Analysis of Anti-inflammatory Effect of Scopoletin and Hesperetin in Combination to Mice

目的：研究白花马鞍藤中主要成分东莨菪亭和橙皮素的相互作用。

Objective : To investigate the interaction of major constituents in Ipomoea Pescaprae ( scopoletin and hesperetin ) .

橙皮苷本身生物利用度较低（25%），而苷元橙皮素半衰期短，口服给药后消除快，需频繁给药来维持有效血药浓度，从而限制了它们的临床应用。

But the difficulty with hesperidin is low bioavailability ( 25 % ) . Hesperetin needs frequent drug administration to keep the level of plasma concentraion , because of its short biological half-life period and fast elimination after oral administration , which limits their clinical application .

其主要来源于橙皮苷的水解，其糖苷在人肠道菌群作用下水解生成橙皮素而发挥作用。在药材陈皮、青皮、枳壳中含量也很高，是其中主要的药效活性成分之一。

Under the effect of intestinal flora , the glucoside is hydrolyzed into hesperetin and come into play . Hesperetin contents very high in crude medicine such as dried and green orange peel , and becomes one of their active ingredient .