秋水仙碱

C组：秋水仙碱预防组；

Group C : colchicine group ;

它能够在秋水仙碱位点抑制微管蛋白的聚合，诱导癌症细胞的凋亡，目前已进入II期临床。

It inhibits microtubule polymerization by binding to the colchicine binding site on β - tubulin and induces the cancer cell apoptosis .

秋水仙碱则对上述指标均有改善作用（P＜0.05～0.01）。

In contrast , all above mentioned indications were improved by Col ( P < 0.05 ~ 0.01 ) .

秋水仙碱对LPS诱导巨噬细胞TNF-α基因表达的抑制作用

Suppression of LPS-induced tumor necrosis factor - α gene expression in macrophages by microtubule disrupting agents

利用紫外光谱法和电化学方法同时对秋水仙碱与DNA相互作用进行了研究，得出单链DNA和双链DNA与秋水仙碱的作用方式有所不同，结合能力也有改变。

Interaction between colchicine and DNA is also studied , and find that single-stranded DNA differs from double-stranded DNA in mechanisms of interaction with colchicine and binding capacity .

秋水仙碱引起CHL细胞有丝分裂纺锤体损伤的观察

Observations on the mitotic spindle damage induced by colchicine

单倍体再用秋水仙碱处理后获得DH系，所得材料对油菜功能基因组学的研究可能有一定的价值。

We generated completely homozygous DH lines as a model system for functional genomics work in B.

FDA拥有一项可使尚未批准但已上市的药品如秋水仙碱处于其管理框架下的措施。

The FDA has an initiative underway to bring unapproved , marketed products like colchicine under its regulatory framework .

实验SD大鼠随机分为正常组、CCl4组、川芎嗪组和秋水仙碱组。

The SD rats were randomly divided into normal group , CCl 4 、 TMP and colchicine groups .

尽管专业从医人员使用秋水仙碱治疗痛风已有多年，但该药一直未被FDA批准。

Colchicine has been used by healthcare practitioners for many years to treat gout but had not been approved by the FDA .

观测到生理pH7.43条件下秋水仙碱使BSA的紫外吸收峰增强，特征荧光峰淬灭。

In physiological condition ( pH 7.43 ), colchicine treatment led to the increasing of UV absorption and the quenching of intrinsic fluorescence of BSA .

FDA提醒医疗卫生专业人士使用上述新的剂量方案，并警告当患者使用秋水仙碱时可能存在严重药物相互作用。

The FDA is alerting healthcare professionals to this new dosing regimen and also warning about the potential for severe drug interactions when patients take colchicine .

用CCl4造成大鼠肝纤维化模型，用汉防己甲素进行抗肝纤维化治疗，并与传统抗肝纤维化药物秋水仙碱进行比较。

Tetrandrine was used to treat liver fibrosis induced by CCl4 in rats , and its action was compared with colchicine .

目的探讨秋水仙碱（Col）和长春新碱（Vin）诱导tk基因分子突变类型及机制。

AIM To investigate the type and mechanism of colchicine ( Col ) and vincristine ( Vin ) induced tk gene mutation .

秋水仙碱阻滞细胞周期于分裂中期，DAPI荧光染色分析染色体端-端融合；

Cell cycles were blocked in metaphase by colchicina . Chromosome end-to-end fusions were analyzed by DAPI fluorescein stain .

目的：研究秋水仙碱对日本血吸虫感染的小鼠肝葡糖胺基聚糖（GAG）代谢的影响。

About Alkali Saving AIM : To study the effect of colchicine on hepatic glycosaminoglycan ( GAG ) metabolism in mice infected with Schistosoma japonicum .

实验结果表明：熊果酸对肝组织及体外培养HSCFas/FasL基因mRNA的表达可明显上调，其上调作用均好于秋水仙碱组。

The experimental results show that : Ursolic acid can make the liver tissue and the HSC expression of Fas / FasL mRNA expression in vitro significantly raised , better than the colchicine group .

结论秋水仙碱、道诺霉素和5－Fu对RG细胞有明显抑制作用。

Conclusion Colchicine , daunomycin and 5-Fu have an effective inhibition on human retinal glial cell proliferation , which might be the potential candidates for the treatment of proliferative vitreoretinopathy .

与秋水仙碱治疗组相比，小剂量中药治疗组微高，但无明显差异（P＞0.05），大、中剂量中药治疗组明显增高（P＜0.05）。

Compare with the colchicines grope , the level of the low dose ECM grope is modestly higher , but the difference is not marked ( P > 0.05 ) , the levels of the middle and high dose ECM gropes are markedly increased ( P < 0.05 ) ;

结果：空白对照组mRNA表达低于其他各组（P<0.05），乌梅丸各组α1（Ⅰ）型前胶原mRNA的表达低于模型组和秋水仙碱组、小柴胡汤组（P<0.05）。

Result : The expression of mRNA in blank group was lower than that in other groups ( P < 0.05 ); the expression of α 1 ⅰ procollagen mRNA in each Wumei groups were lower than that in all other groups .

目的评价有丝分裂抑制剂长春新碱和秋水仙碱的遗传毒性，并比较短期和长期tk基因突变试验的检出灵敏度。

Objective To evaluate the genotoxicity of two mitotic inhibitors vincristine and colchicine , and to compare the detecting sensitivity of tk gene mutation assay with short-and long-term treatment by them .

目的：探讨环磷酰胺、秋水仙碱联合应用对急性缺血性中风病人CD11a、CD11b、CD18和CD54的影响。

Objective : To explore the effect of cyclophosphamide and colchicine on CD11a , CD11b , CD18 and CD54 in patients with acute ischemic stroke .

本文利用脑内移植技术，研究胚胎海马修复成年大鼠隔核齿回海马本体的神经元连接用5μg秋水仙碱（colchicine）以局部注射的方式，选择性地损毁大鼠海马齿回的颗粒细胞。

Reconstruction of damaged neuronal connections by a neural graft was studied in adult rat hippocampus . Dentate granule cells of the rat were selectively destroyed by a local injection of 5 μ g colchicine into the hippocampus .

该药的活性成份为秋水仙碱（colchicine），是一种来源于植物秋藏红花或秋水仙的干燥种子的复杂化合物。

The medication 's active ingredient is colchicine , a complex compound derived from the dried seeds of a plant known as the autumn crocus or meadow saffron ( Colchicum autumnale ) .

因此，本论文主要针对用秋水仙碱人工诱导银杏2n雄配子及其相关技术进行了探索性研究，为通过用二倍体花粉与正常银杏雌株授粉培育三倍体植株打下初步基础。

The research on the technology using colchicines to manually induce 2n pollen was described This paper , and would establish a base for the triploids breeding by pollinating to female Ginkgo biloba with 2n pollen .

传统使用秋水仙碱治疗FMF已有多年，但这一治疗方法从未被正式批准。

Physicians have prescribed colchicine for FMF for many years based on studies showing that it reduced the frequency of attacks but use of colchicine for FMF had never been approved .

在溃疡组的第3、6、9和20d，腹腔注射秋水仙碱后取胃窦粘膜。

After experimental gastric ulcer was induced , the mice of three groups received intraperitoneal injection of colchicine and were sacrificed 3h later at 3 , 6 , 9 and 20 days , respectively .

结果表明：在组织培养条件下添加10～50ppm秋水仙碱，是诱发丹参多倍体的行之有效的方法。

The results indicated that it was an effective way to add 10 & 50 ppm colchicine in MS medium in tissue culture for inducing polyploidy .

0.1%秋水仙碱浓度处理24h的后代的节间直径高于同样浓度秋水仙碱48h处理得到的后代，而相同秋水仙碱浓度相同时间处理的后代间也存在差异；

The internode diameter of mutants induced by 0.1 % concentration colchicines treated 24 hours were higher than that of mutants induced by the same concentration colchicines treated 48 hours , and there was difference among mutants induced by colchicines at the same concentration and treating time ;

应用秋水仙碱混合二甲基亚砜的方法，对烟草单倍体进行加倍，采用气孔保卫细胞叶绿体计数法筛选加倍单倍体，成功构建烟草DH系；

Applying Dimethylsurfoxide ( DMSO ) to colchicines to double haploids in tobacco and using the method of accounting the number of stoma chloroplasts in guard cell to determine haploids , diploids or polyploids of tobacco successfully constructed the doubled haploid populations derived from two crossing groups .