钾离子通道

花生四烯酸敏感和机械牵张门控的双孔钾离子通道TREK的研究进展

Recent advances in the study of arachidonic acid-sensitive and mechano-gated tandem-pore-domain potassium channels & TREK

近年研究发现，MS多种炎性细胞的钾离子通道参与了其自身免疫性发病过程，控制炎性细胞上钾离子通道为MS的治疗提供了新的途径。

Recently , potassium channels in inflammatory cells were found to be involved in the immunopathogenesis of MS , and regulation of potassium channels provide a novel immunomodulatory therapy in MS.

蛋白激酶C对内向整流钾离子通道的调节机制

Modulation mechanism of PKC upon inwardly rectifying potassium channels

钾离子通道阻滞剂对SD大鼠前列腺上皮细胞的增殖作用

Potassium Channel Blocker Regulates the Proliferation of Prostatic Epithelial Cells in SD Rats

结果表明，通过P区特征序列分析和蛋白质序列相似性分析对钾离子通道蛋白质进行预测分类都存在困难。

The results indicate that it is difficult to classify K + channels based on signature sequence in P-domain or the similarities of K + channels .

目前，人们对电压依赖的钾离子通道（Kv通道）的研究已较为深刻。

At present , the voltage dependent potassium channel ( Kv channel ) has been deeply studied .

选择敏感性ATP钾离子通道为抗高血糖药物的作用靶标。

We choose ATP-sensitive K + channels as the target of new type of antihyperglycemic drugs .

全新结构钾离子通道开放剂先导化合物的设计合成与QSAR的研究

Design and Synthesis of Novel Potassium Channel Openers and QSAR Studies

目的探讨线粒体膜上ATP敏感的钾离子通道开放药物二氮嗪防治Aβ1～42细胞毒性作用及其分子学机制。

Objective To investigate whether K + channel opener diazoxide could protect cells from A β 1-42-induced cytotoxicity and its molecular mechanism .

结论单一类型钾离子通道开放并不是门静脉高压症鼠动脉对NE低反应的主要原因。

Conclusion Opening of a single type of potassium channels is not the major cause of reduced vascular NE responsiveness in portal hypertension .

目的：研究血管紧张素Ⅱ（AngⅡ）对乳鼠缰核（Hb）细胞膜上钾离子通道活动的影响，以了解Hb内AngⅡ的作用机制。

Aim : To study the effects of Ang ⅱ on the I K channel in isolated rat habenula ( Hb ) nucleus neurons .

目的：观察5-氟脲嘧啶（5-FU）对口腔癌Tb细胞增殖活性以及钾离子通道功能的影响，进一步揭示5-FU的抗肿瘤机理，并初步探讨钾离子通道与肿瘤细胞增殖的关系。

AIM : To evaluate the effects of 5-Fluorouracil ( 5-FU ) on cell proliferation and potassium channel function in oral cancer cell line Tb .

ATP激活性钾离子通道和钙离子激活性钾离子通道抑制剂明显降低脊髓刺激扩张血管，表明这两种钾离子通道在脊髓刺激扩张血管中起到重要作用。

ATP-activated and calcium-activated potassium ion channel inhibitor significantly decreased SCS induced vasodilation , implied that these two ion channels played important roles in SCS induced vasodilation .

TREK钾离子通道电流具有自发性、电压和时间依赖性、无失活等特性。

The current of TREK potassium channels shares the same characteristics of spontaneous , voltage - and time-dependent , non-inactivating .

TREK类双孔钾离子通道的另外一个电生理特性在于，它们对于经典的钾通道阻断剂如4-AP、TEA、Cs~+等不敏感。

The other character is that they are not sensitive to classic potassium channel antagonists such as 4-AP , TEA and Cs ~ + .

目的探讨ATP钾离子通道开放剂匹那地尔对未成熟心肌常温缺血/再灌注损伤的保护作用。

Objective The purpose of this study was to investigate the effect of pinacidil , an ATP-sensitive K + channel opener in protecting myocardium of immature rabbit heart from ischemia-reperfusion injury .

目的：观察溶血磷脂酸（LPA）对豚鼠心肌细胞电压依赖性钾离子通道电流的作用。

Objective To observe the effects of lysophosphatidic acid ( LPA ) on voltage dependent potassium current in myocytes of guinea pig .

研究结论：1.钙离子通过电压门控钙离子通道和以及钙离子激活的钾离子通道，对FCM模型的放电活动及动作电位波形产生影响。

Through voltage control calcium channels and the calcium activated potassium channels , calcium ions have an influence on the firing and the shape of action potentials in FCM model .

目的探讨与钾离子通道HERG相关的药物在肿瘤治疗中的靶向调节作用。

ObjectiveTo study the targeted modulation of the drugs targeted ion channel-HERG .

在这些类型的钾离子通道中，大电导钙激活钾离子通道（large-conductancecalcium-activatedpotassiumchannels，BKCa）在平滑肌上广泛表达，在调节膜电位及血管平滑肌张力方面具有重要作用。

Large-conductance calcium-activated potassium channels ( BKCa ) are widely expressed in VSMC , Which have the important functions in regulation of membrane potential and vascular smooth muscle tone .

人肝癌HCC-9204细胞膜钾离子通道特性的研究

A study on the characteristics of the potassium channel in human hepatocyte carcinoma cell line HCC-9204

目的：研究PC12细胞上的钾离子通道门控动力学及神经生长因子（NGF）对其影响。

AIM : To study the gating kinetics of voltage-dependent K + channels in clonal pheochromocytoma ( PC12 ) cells and the effect of nerve growth factor ( NGF ) on it .

尼可地尔是一种线粒体ATP敏感性钾离子通道开放剂（mitoKATP），具有心肌保护作用。

Nicorandil isa kind of mitochondrial ATP-sensitive potassium channels open agent ( mitokATP ), itcan protection the myocardial and maintain the normal function of the heart .

转甜瓜钾离子通道基因MIRK拟南芥植株的耐盐性分析

Salt-tolerance Analysis of the Arabidopsis Transformed with Melon Potassium Channel Gene MIRK

结论人肝癌HCC-9204细胞膜存在钾离子通道，其主要类型可能是电压依赖性钾通道。

Conclusion Voltage-gated K ~ + channel maybe one of the important types in human hepatocyte carcinoma cell line HCC-9204 .

目的：观察钾离子通道阻滞剂四乙胺（TEA）、四氨基吡啶（4-AP）、格列本脲（Glib）对体外培养SD大鼠前列腺上皮细胞增殖的调节作用。

Objective : To investigate the regulatory effect of potassium channel blocker ( tetraethylammonium [ TEA ] , aminopyridine [ 4-AP ] , glibenclamide [ Glib ] ) on the proliferation of SD rat prostatic epithelial cells in vitro .

目的：研究高胆固醇血症（hypercholesterolemia，HC）兔胆管Oddi括约肌（SO）收缩反应及钾离子通道活性的变化情况，并探讨其机制。

AIM : To study the changes of the contractile responses and potassium ion channel activity in sphincter of Oddi ( SO ) from rabbits with hypercholesterolemia ( HC ), and elucidate the underlying mechanisms responsible for these changes .

BK钾离子通道是一种大电导钾离子通道，能够被Ca2+、Mg2+和电压所激活，在许多生理过程中发挥重要作用。

BK channel is a large conductance potassium channel , which could be activated by intracellular Ca + , Mg2 + as well as by membrane depolarization , and plays a central role in numerous physiological processes .

为研究甲状旁腺素（PTH）促大鼠成骨样肉瘤细胞（UMR106）增殖作用及与钾离子通道活动的关系。

Objective : To study the effect of on PTH on cell proliferation in rat osteoblast like cells line and the relationship of K + channel and the proliferation .

目的通过检测ATP敏感性钾离子通道开放剂-尼可地尔（Nicorandil）对离体豚鼠乳头肌标本的张力和动作电位在缺血前后的影响，明确Nicorandil的心肌保护作用，探讨其细胞水平的作用机制。

OBJECTIVE To verify the myocardial protection effects of Nicorandil by detecting its influence on isolated guinea pig papillary muscle 's tension and action potential during peri-ischemic period ; Try to find out its cellular mechanism as well .