Spermatogonia Stem Cells

It was confirmed that male plzf deficient mouse appear gradualness infertility after birth . It shows spermatogenic cells exhaustion . The capability of self-renew in spermatogonia stem cells was absent .

已证实plzf缺陷的雄性小鼠出生后会出现渐进性的不育，表现为生精细胞耗竭，即精原干细胞自我更新能力缺失。

Objective To obtain a simple method to isolate and purify spermatogonia stem cells .

目的寻求一种获取小鼠的生精干细胞的简单方法。

It means the cells can differentiate downward and self-renew . Plzf is noticeable in the studies of maintain spermatogonia stem cells self-renew .

精原干细胞具有不对称分裂的特性，即可向下分化与自我更新，在如何维持精原干细胞自我更新功能的研究中，plzf的作用引人注目。