daz

Determination of the DAZ Gene in Human Sperm by Quantitative PCR

定量PCR法测定人精子中DAZ基因的相对含量

Use of fluorescent PCR in diagnosis of male infertility related DAZ Gene

荧光PCR在男性不育相关DAZ基因检测中的运用

Idiopathic male infertility and partial copy deletion of DAZ gene family

男性原发不育与DAZ基因家族部分拷贝缺失

The clinical significance of DAZ and RBM gene detection in male infertility

男性不育症患者RBM、DAZ基因检测的临床意义

Diagnosis of the DAZ gene deletion in human sperm of infertile men by quantitative polymerase chain reaction

定量聚合酶链反应法对不育患者精子中DAZ基因缺失的诊断

Study on DAZ Gene Copy Deletion in Severe Oligozoospermia Sperm Donor for ICSI

严重寡精症ICSI精子供体的DAZ基因拷贝缺失研究

Methods DAZ gene of peripheral blood leukocytes was detected by PCR technique in 38 azoospermia and 12 severe oligozoospermia patients .

方法应用PCR技术对50例无精子症和严重少精子症患者（其中无精子症38例，严重少精子症12例）的外周血细胞进行DAZ基因检测。

Objective : To study the relationship of the sperm quality , DAZ ( deleted in azoospermia ) gene and the male infertility .

目的：探讨精子质量及DAZ（DeletedinAzoospermia）基因与男性不育症的关系。

Analysis of Chromosomal Abnormality in Azoospermia Relationship between the entire DAZ genes as well as DAZ1 / DAZ2 deletion and azoospermia

无精症患者的染色体异常分析无精症DAZ基因缺失研究

Results : 54 patients with chromosomal aberration , 3 patients with DAZ gene deletion and 5 patients with mutations in the exon A of androgen receptor gene were found .

结果139例原发不育患者G、C显带发现54例染色体核型异常，3例DAZ基因缺失，5例雄激素受体基因外显子A发生点突变。

[ Objective ] To investigate the relationship of the entire deleted in azoospermia ( DAZ ) genes as well as DAZ1 / DAZ2 deletion and azoospermia .

目的探讨无精症患者的DAZ基因全缺失和DAZ1/DAZ2缺失。

Objective To analyze the pattern and prevalence of partial copy deletion of deleted-in-azoospermia ( DAZ ) gene in the azoospermia factor C ( AZFc ) region of patients with idiopathic azoospermia or severe oligozoospermia .

目的分析原发无精症和严重少精症患者Y染色体无精症因子C区（azoospermiafactorC，AZFc）DAZ基因（deleted-in-azoospermia，DAZ）部分拷贝缺失的类型与频率。

Conclusion RBM and DAZ genes are one of the important candidates for azoospermia factor ( AZF ) . Microdeletion on RBM and DAZ is a major cause of azoospermia and severe oligozoospermia leading to male infertility .

结论RBM和DAZ为无精子因子（AZF）的重要候选成分，RBM及DAZ微缺失是引起无精子和严重少精子并造成男性不育的重要原因之一。

Methods Deletions in 25 azoospermic and 27 severe oligozoospermic Chinese patients were screened by STS PCR strategy . A total of 23 STSs in interval 6 of Yq , including 4 STSs in the deleted azoospermia gene ( DAZ ) region were analyzed .

方法运用STSPCR法对25例无精症和27例严重少精症患者的Y染色体interval6的23个序列标签位点（STS）进行缺失筛查。

Conclusion The frequency of partial copy deletion of DAZ gene in Chinese idiopathic azoospermia or severe oligozoospermia patients is much higher than that of fertile controls , suggesting that the deletion of DAZ1 / DAZ2 may be one of the important genetic etiological factors of spermatogenesis damage .

实验组与对照组DAZ1/DAZ2共缺失率差异有极显著性。结论原发无精和严重少精症存在较高频率的AZFc区DAZ基因的部分缺失，这可能是中国男性原发不育的病因之一。

[ Methods ] The entire DAZ genes and DAZ1 / DAZ2 deletion were analyzed by multiplex polymerase chain reaction ( multi-PCR ) and polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) in 228 infertile patients with azoospermia and 252 normospermic men as controls .

方法应用多重PCR和PCR-RFLP技术，对252个正常生精男性和228例无精症患者的DAZ基因全缺失和DAZ1/DAZ2缺失进行了分析。