gada

C-peptide and GADA screening are necessary for early etiological classification .

C肽及GADA测定可协助早期正确分型。

Combined Use of GADA and ICA in Type of Diabetes and Screen out LADA from Type 2 Diabetes

GADA、ICA联合检测在糖尿病分型及从2型糖尿病中筛选出LADA的临床意义

The relationship between GADA , ICA and glucose metabolism or C-peptide in patients with liver cirrhosis

肝硬化患者谷氨酸脱羧酶抗体及胰岛细胞抗体与糖代谢及C肽的关系

The prevalence of GADA positive was 5.1 % for men and 3.2 % for women ( P > 0.05 ) .

男女不同性别GAD抗体阳性率分别为5.1%和3.2%（P>0.05）。

Combined screening of GADA , IA-2A and IAA in first-degree relatives of patients with type 1 diabetes

1型糖尿病一级亲属GADA、IA-2A与IAA联合检测的价值

Results : Blood C-P level in the positive group of GADA was significantly lower ( P < 0.01 ) than that in the negative group of GADA ;

结果：GADA阳性T2DM组血C-肽水平显著低于GADA阴性的T2DM组（P<0.01）；

Altogether 782 ( 36.7 % ) of the patients were done with GADA examination and 4.2 % of them were GADA positive .

门诊GAD抗体检测782例（36.7%），阳性率为4.2%。

The positive rates of insulin autoantibodies such as GADA , ICA and IAA were 57.14 % , 17.14 % and 8.57 % respectively ;

胰岛自身抗体GADA、ICA和IAA的阳性率分别为57.14%、17.14%和8.57%。

Objective : To study clinical significance of glutamic decarboxylase autoantibody ( GADA ) and islet cell cytoplasm autoantibody ( ICA ) in type 2 diabetes mellitus .

目的：探讨在2型糖尿病患者中联合检测谷氨酸脱羧酶抗体（GADA）和胰岛细胞自身抗体（ICA）的临床意义。

The frequencies of GADA positive in patients with different duration ( 1 year , 5 years , 10 years and more ) were 4.4 % , 4.8 % , 1.7 % and 4.9 % ( P > 0.05 ) respectively .

1,5,10及10年以上不同病程糖尿病患者GAD抗体阳性率分别为4.4%，4.8%，1.7%和4.9%（P>0.05）。

[ Objective ] To study the relationship between positive rate of ICA , GADA , IAA and the β - cell function , and evaluate the significance of combined auto-antibody detection in diagnosis for Type-1 diabetes mellitus .

[目的]了解儿童糖尿病胰岛细胞抗体（ICA）、谷氨酸脱羧酶抗体（GADA）和胰岛素自身抗体（IAA）阳性率及其与儿童胰岛功能的关系，评价自身抗体测定对1型糖尿病的诊断价值。

Conclusion The level of GADA and ICA in the hepatocirrhosis patients get close to that of LADA indicating that the mechanism of autoimmune injure in the insulin cell are similar to that of LADA .

结论肝硬化患者血清GADA和ICA阳性率与LADA非常接近，说明肝硬化患者存在着与LADA发病机理相似的胰岛细胞自身免疫性损伤，而且随着肝功能下降血清ICA阳性率进行性上升。

Objective : To evaluate the significance of combined determination of glutamic acid decarboxylase antibodies ( GADA ), islet cell antibodies ( ICA ) and insulin autoantibodies ( IAA ) in precaution of type 1 diabetes mellitus .

目的：评价联合检测谷氨酸脱羧酶抗体（GADA）、胰岛细胞抗体（ICA）和胰岛素自身抗体（IAA）对1型糖尿病的早期诊断价值。

Before treatment the patients in both groups showed positive serum antibodies to glutamic acid decarboxylase ( GADA ) or to islet cell cytoplasmic antigens ( ICA ) or to protein tyrosine phosphatase ( IA-2A , P < 0 . 05 ) .

治疗前，两组患者存在血清谷氨酸脱羧酶抗体（GADA）、胰岛细胞抗体（ICA）、蛋白酪氨酸磷酸酶抗体（IA-2A）阳性。

Methods : 376 healthy Han controls were recruited and measured for GADA and IA-2A , 300 ones were measured for IAA . Among them , 278 ones were typed for the polymorphisms of HLA-DQ genotypes with PCR sequencing-based typing method .

方法：采用放射配体法检测376例中国汉族正常人群GADA、IA-2A与300例正常人群IAA，其中278例采用PCR-直接测序法确定HLA-DQ基因型。

Objective To explore the clinical significance of combined detection of glutamic acid decarboxylase antibody ( GADA ) insulin autoantibody ( IAA ) and islet cell autoantibody ( ICA ) in first degree relatives of patients with type 1 diabetes mellitus ( DM1 ) .

目的：探讨联检1型糖尿病（DM1）一级亲属谷氨酸脱羧酶抗体（GADA）、胰岛素自身抗体（IAA）和胰岛细胞抗体（ICA）的临床意义。

Glutamic acid decarboxylase antibody ( GADA ) may be a better screening test for predicting insulin dependency , the prediction of GADA combined with protein tyrosine phosphatase antibody may approximate to 100 % , whereas islet cell antibody assay may be needed in the adolescent patients .

谷氨酸脱羧酶抗体为成年糖尿病患者预示胰岛素依赖的较好的筛查试验，与酪氨酸蛋白磷酸酶抗体联合检测可达近100%的预报价值；而青少年糖尿病患者则还需检测胰岛细胞抗体。