histones

High resolution NMR studies of nucleic acids and histones

核酸和组蛋白的高分辨核磁共振研究

Histones are a group of proteins that are associated with chromosomes .

组蛋白是一类结合在染色体上的蛋白质。

Isolation , expression and purification of core histones and chromatin assembly associated proteins

核心组蛋白及染色质组装相关因子的分离、表达及纯化

Acetylation of histones and other nuclear proteins plays an important role in cancer development and progression .

组蛋白和其它核蛋白的乙酰化在肿瘤的发生发展中起着重要作用。

High resolution ~ 1h 、 ~ ( 31 ) p NMR studies of histones and nucleic acids

组蛋白和核酸的1~H、（31）~P核磁共振研究

The Raman spectroscopic study of complexation and isolation of DNA and histones in chromatin

染色质的DNA与组蛋白复合和分离的拉曼光谱研究

For example , they found that proteins called histones , which help control a gene 's activity , were being altered .

他们发现一种有助于控制基因活性的组蛋白的改变。

In eukaryotic cells , DNA is packaged with histones in the form of chromatin .

在真核细胞中，DNA与组蛋白包装形成染色质。

Furthermore , experimental data revealed that three regions of strong interactions between core histones and DNA sequences in a nucleosome .

还有实验数据揭示在一个核小体中，组蛋白和DNA相互作用有三个作用很强烈的区域。

In addition to histones , several other cellular proteins including transcription factors and tumor suppressor are subject to methylation .

除了组蛋白之外，很多其它的细胞功能蛋白，包括转录因子和抑癌因子等，都被发现可以发生甲基化修饰。

Histones are basic proteins .

组蛋白是碱性蛋白。

Histones are protein - found in eukaryotic cell nuclei , tightly bound to DNA , which has many phosphate groups .

组蛋白是存在于真核细胞核中的与含很多磷酸基团的DNA紧密结合的蛋白质。

Methylation is a major posttranslational modification for histones in eukaryotes .

甲基化修饰是真核生物中核小体组蛋白的一种极为重要的翻译后修饰。

This architecture of chromatin is strongly influenced by posttranslational modifications of the histones .

染色质的结构受组蛋白翻译后修饰的影响。

Histones H3 and H4 are two of the five main histones that regulate the structure of chromatin .

组蛋白H3和H4是5个主要的组蛋白中的两个，这五个组蛋白调节染色质结构。

And DNA molecules binds to histones and non-histone proteins to form chromatin to engage in this process .

在细胞中，DNA分子与组蛋白及非组蛋白结合形成可进行反复组装与去组装的染色质分子参与这一过程。

Histones were extracted from S.cerevisiae cells by Acid Extraction Method . It is the basis of nucleosome reconstitution in vitro .

酸抽提法提取酵母细胞的组蛋白，这是核小体体外组装的基础。

Covalent modifications , such as acetylation occur in the N-terminal amino acids of histones .

在真核生物中，组蛋白是染色质基本结构一核小体中的重要组成部分，其N末端氨基酸残基可发生乙酰化等共价修饰。

Arginine methylation broadly occurs in histones and has been linked to transcriptional regulation , cell cycle regulation and DNA repair .

组蛋白上广泛发生的精氨酸甲基化修饰与基因的转录调控，细胞周期调控以及DNA损伤修复等过程都密切相关。

These proteins helping DNA package are called histones and the basic element that formed by DNA and histones is called nucleosome .

这些帮助DNA堆积的蛋白叫做组蛋白，DNA围绕组蛋白形成的基本堆积单位叫做核小体。

Histone deacetylase is protein that can influence the cell cycle , differentiation and apoptosis through the modification of acetyl level of histones .

组蛋白去乙酰化酶是一类通过调节组蛋白乙酰化的程度来影响细胞周期、分化和凋亡的蛋白。

Epigenetic marks , such as the modifications of the histones , are also important for the specialisation of the body 's cells .

表观遗传标记，例如组蛋白修饰，对于机体细胞的分化也很重要。

These results suggest that an accumulation of highly acetylated histones is due to inhibition of histone deacetylation by butyrate .

冷追击实验的结果提示，丁酸钠引起高乙酰化组蛋白的积蓄，确是通过其对组蛋白脱乙酰基过程的抑制作用而实现的。

Histones make up the spool of proteins around which DNA winds so that it is packaged compactly in the nucleus .

组蛋白组成蛋白线轴，DNA缠绕在它的周围，使DNA紧密地包装在细胞核中。

~ 1h , ~ ( 13 ) c , ~ ( 31 ) p magnetic resonance studies on nucleic acids and their interaction with histones

核酸及其与组蛋白相互作用的~1H、~（13）C、~（31）P核磁共振研究

The reactivity of histones with some MAbs reveals the possible pathogenesis of anti-histones antibody production in autoimmune diseases .

组蛋白与某些单克隆抗体发生的交叉反应性揭示了在自身免疫性疾病中抗组蛋白自身抗体产生的可能致病原因。

In eukaryotic genes , histones are subject to covalent modifications and histone lysine methylation plays an important role in epigenetics .

在真核基因中，组蛋白会发生多种共价修饰，其中组蛋白的甲基化在表观遗传学中起重要作用。

The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones .

植物基因组的功能依赖于染色质标记，诸如DNA的甲基化和组蛋白的转录后修饰。

During spermatogenesis the histones in the chromatin are replaced by other more basic proteins leading to a more condensed structure of the DNA .

在精子生成过程中，核小体组蛋白被其他更为碱性的蛋白所替代，使DNA的结构变得更为集缩。

Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues .

过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。