idiotype

Construction and expression analysis of idiotype TCR V β 2 DNA vaccine in vitro

独特型TCRVβ2DNA疫苗的构建和体外表达检测

Relationship between anti idiotype antibody against anti-HBs and individuals of Different HBV infection

抗HBs-抗独特型抗体与各型乙肝病毒感染者的关系

Scientists call this claw shape the antibody molecule 's idiotype .

科学家称这种爪型为抗体微小颗粒的遗传型。

To the idiotype of anti - HBs showed very activity .

而抗独特型抗体（Ald）阳性单明显高于其它组，且针对抗-HBs独特型的LTT反应也十分活跃。

Gene and protein expression of idiotype DNA vaccine of TCR β chain of T cell lymphoma

T淋巴瘤TCRβ链独特型DNA疫苗在小鼠骨骼肌中的基因及蛋白表达

To explore the preparation of specific immune RNA on idiotype and further study immunotherapy of tumors .

为进一步研究肿瘤的免疫治疗，探索一种型特异、体专一的肿瘤免疫核糖核酸的制备方法。

Conclusions : ( 1 ) Anti idiotype vaccine is safe for clinic active immunotherapy .

结论：（1）疫苗化的2H4和5D3用于晚期鼻咽癌病人的主动免疫治疗是安全的。

Induction of Active Antitumor Immune Response by Myeloma Idiotype Protein-pulsed Dendritic Cells

骨髓瘤独特型抗原致敏树突细胞诱导的主动免疫反应

The Establishment of Cell Lines of Hybridoma Secreting Idiotype Antibodies Against IBDV

分泌抗IBDV独特型抗体细胞株的建立

Aim : To test the gene expression of idiotype DNA vaccine of TCR β chain of T lymphoma .

目的：检测T淋巴瘤TCRβ链独特型DNA疫苗的基因表达。

A preliminary result of idiotype / antiidiotype interaction inhibition reaction for detecting circulating membrane antigen was also presented .

本文还报告了独特型/抗独特型（8SE4/抗8SE4）抑制试验检测循环表膜抗原的初步结果。

Antibody idiotype is the antigen determinant of antibody .

抗独特型抗体（Ab2）是指针对独特型抗体（Ab1）的独特型抗原决定基产生的抗体。

THE SIMULATION MODELS FOR THE POPULATION DYNAMICS OF CITRUS RED MITE Scientists call this claw shape the antibody molecule 's idiotype .

柑桔全爪螨自然种群动态的模拟模型科学家称这种爪型为抗体微小颗粒的遗传型。

Detection of circulating membrane antigen of schistosome in schistosomiasis by Dot-ELISA and idiotype / antiidiotype interaction inhibition test

斑点-ELISA和独特型/抗独特型抑制试验检测日本血吸虫病患者循环表膜抗原

Objective To investigate the specific antitumor immune response induced by idiotype protein ( Id ) - pulsed dendritic cells ( DC ) in vitro .

目的研究树突细胞（DC）介导的独特型瘤苗诱导骨髓瘤抗原特异性细胞毒性T淋巴细胞（CTL）的抗肿瘤免疫反应。

The strategy of tumor vaccine involves gene vaccine , peptide or protein vaccine , tumor cell vaccine modified by gene and anti idiotype antibody vaccine .

肿瘤疫苗策略包括基因疫苗、肽和蛋白疫苗、基因修饰的肿瘤细胞疫苗以及抗独特型抗体疫苗等。

Conclusion : The idiotype DNA vaccine of TCR β chain of T lymphoma can effectively express gene production in the skeletal muscles of rats .

结论：T淋巴瘤TCRβ链独特型DNA疫苗在小鼠骨骼肌中有效地表达了基因产物。

In order to reduce the human anti mouse antibody response and obtain optimal antigenicity , anti idiotype single chain which mimicking ovarian cancer antigen has been humanized .

为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。

These data indicate that the idiotype ( Id ) network modulate the immune response to PHSA and that the anti-Id specific for anti-PHSA have the internal image composition .

本研究不仅表明了针对PHSA的免疫应答中独特型网络调节的客观存在，而且在其抗独特型抗体（anti-Id）中，的确存在具有PHSA内映像的成分。

In immunology network people think antibody molecule have both the character of react with antigen and the character of immunogenicity ( idiotype , Id ) which can activate the lymphocyte to produce anti-idiotypic antibody , AId .

免疫网络学说认为抗体分子除具有与抗原结合的特性外，还具有自身免疫原性的独特型（idiotype，Id），可激活淋巴细胞产生抗独特型抗体（anti-idiotypicantibody，AId）。

This study was designed to investigate in vitro killing effect of tumor-specific cytotoxic T lymphocytes ( CTLs ) stimulated by idiotype protein ( Id ) - pulsed dendritic cells ( DCs ) on autologous MM cells .

本研究旨在探讨负载Id的DC独特型瘤苗对自体MM细胞的体外杀伤作用。

The main procedures were as follows : coating by mouse IgG subclass with low affinity to SpA such as IgG1 or IgM , adding anti-idiotype , then HRP-SpA was used to display the binding between idiotype and anti-idiotype .

主要步骤为：用以低亲合力结合SpA的小鼠免疫球蛋白如IgG1包被，加入待检抗独特型抗体，最后以HRP-SpA显示其反应。

RESULTS The positive rate was 100 percent for CP 2 and 66.7 % for idiotype respectively among those with non mucinous epithelial carcinomas , which were higher than those with ovarian epithelial mucinous carcinomas , non epithelial ovarian carcinoma and genital malignancies ( P < 0.01 ) .

结果非粘液性卵巢上皮癌抗原阳性率为100%，抗体阳性率为66.7%，高于粘液性卵巢上皮癌、非上皮性卵巢恶性肿瘤及生殖系统其他恶性肿瘤，并且明显高于卵巢良性肿瘤（P<0.01）。

The main reason of the relapse is the existence of the residual tumor cells . The idiotype of membranous immunoglobulin of the B-cell lymphoma is subject to the ideal target of the DNA vaccine , an emerged potent strategy to treat and prevent the relapse of the tumor .

B细胞淋巴瘤肿瘤细胞表面的免疫球蛋白分子存在独特型位点，是DNA疫苗的理想靶标，因此抗独特型DNA疫苗有可能达到治疗和预防肿瘤复发的目的。