mafa

Role of Transcription Factor MafA in Pancreatic Island β Cells

转录因子MafA在胰岛β细胞中的作用

MafA may activate insulin 2 gene transcription in the INS-1 cells .

大鼠INS-1细胞中，转录因子MafA可促进胰岛素基因的转录。

GSK3 may activate insulin 2 gene expression by phosphorylating MafA in rat INS-1 cells .

大鼠INS-1细胞中，GSK3可能通过磷酸化MafA蛋白，进而促进insulin2基因表达。

In currently found , the MafA gene can induce insulin secretion in vitro , and has great significance to the treatment to the diabetes .

目前发现，MafA基因能够诱导体外胰岛素分泌，对糖尿病的治疗有重大的意义。

We have been studying that hepatocytes can be induced into pancreatic B-cells through the introduction of a few factors on islet development ( such as Pdx-1 , MafA and Ngn3 ) .

我们查阅了大量文献都表明，向肝脏细胞引入一个多个胰岛发育的关键因子（如Pdx1、MafA及Ngn3）可以使肝细胞向胰岛细胞的方向进行转化。