中心细胞

病理改变以边缘区B细胞（中心细胞样细胞）为主，13例出现变异大细胞，3例以变异大细胞为主。

The major pathological change was extranodal marginal zone B-cell . The mutant large cells were seen in 13 cases .

具有诊断性淋巴上皮病变，分别为中心细胞样细胞型（2例）及淋巴浆细胞型（1例），经免疫组化证实为单克隆B细胞性。

The lymphoma was derived from the cholangiole mucosa lymphoid cells and had diagnostic lymphoepithelial lesion . They were centrocyte-like cell ( CCL )( 2 cases ) and lymphoplasmacyte ( 1 case ) .

结论：bcl6可作为滤泡中心细胞性淋巴瘤的特异标志而区别于其他类型小B细胞淋巴瘤；

Conclusions bcl 6 may be a useful marker for identifying FL from other small B cell lymphomas .

14d后贴壁生长细胞基本长满单层，中心细胞排列紧密，形态与骨髓间充质干细胞相似。

14 days later , the attached cells were identical with bone marrow mesenchymal cells in morphology , and covered with the whole monolayer , with the central cells arranged tightly .

结果17例RLH生发中心细胞、10例滤泡性淋巴瘤（FL）及4例弥漫性大B细胞淋巴瘤（DLBCL）中等强度表达BCL-6；

RESULTS BCL 6 was expressed moderately in cells within the germinal center of the 17 cases of RLH , in 10 cases of follicular lymphoma ( FL ) and in 4 cases of diffuse large B cell lymphoma ( DLBCL ) .

ACTH与5-HT阳性标志物在2组淋巴结炎组织中分布大致相似，主要位于副皮质区的T淋巴细胞、淋巴滤泡生发中心细胞及巨噬细胞等部位，但表达强度有显著性差异（P<0.05）。

ACTH and 5-HT positive markers in the lymphadenitis tissue of the two groups showed similar distribution , mainly in cortex of lymph gland T lymphocytes and lymph follicle germinal center cellulae and macrophages etc , but expressive intensity had significant difference ( P < 0.05 ) .

结果：21例原发性中枢神经系统淋巴瘤中17例bcl2蛋白表达阳性（810%），阳性瘤细胞多呈弥漫分布，以中心细胞样细胞表达为主。

Results 17 out of 21 cases of primary CNS lymphoma expressed bcl 2 protein ( 81 0 % ) . The positive neoplastic cells were distributed all over the area , which are mainly centrocyte like cells .

38/51（74.5%）DLBCL中可见bcl-6蛋白细胞核表达，表达形式有滤泡样型、中间型、散在型，RLH中可见生发中心细胞均呈bcl-6阳性表达；

The bcl-6 expression in the nuclei was found in 38 / 51 ( 74.5 % ) DLBCL , showing different expression patterns including GC / FL type , intermediate type and sporadic type . The bcl-6 was expressed in the GC cells of RLH .

结果胃粘膜、粘膜下层、肌层及平滑肌瘤内均可见弥漫多量密集成片的中心细胞样瘤细胞浸润，在胃粘膜内并可见淋巴上皮病变。

Results In gastric mucosa , submucosa and the muscle layer of smooth and the uterine leiomyoma , there were diffusive and dense infiltrations of centrocyte like cells , and the lymphoepithelial lesions could be seen in the mucosa of stomach .

滤泡中心B细胞来源淋巴瘤的研究进展

Advance research on germinal - center B cell derived lymphoma

联合培养中心肌细胞诱导结状神经节神经元的迁移及P物质的表达

Neuronal migration and substance P expression induced by cardiac myocytes in co-cultures of nodose ganglion and cardiac myocytes

Bcl-2基因转染对心脏移植排斥反应中心肌细胞凋亡的影响

Effect of Bcl-2 Gene Transfer on Apoptosis of Myocardial Cells in Mice Heart Transplantation Rejection

目的：探测联合培养中心肌细胞对迷走神经结状神经节神经元的迁移和P物质表达的影响作用。

Objective : To determine the effects of cardiac myocytes on nodose ganglial neuronal migration and substance P expression in co-cultures of nodose ganglion and cardiac myocytes of newborn Wistar rats .

3种标记物在淋巴结中的分布大致相同，主要分布在副皮质区的T细胞、淋巴滤泡生发中心B细胞及巨噬细胞等部位。

These 3 molecules had a similar distribution in germinal center of lymph nodes , mainly in the cells of paracortical region , the cells in germinal center of lymph follicles and macrophages , etc.

同时对转录因子E2F1作为一种新的生发中心B细胞型DLBCL的判断指标的可行性进行探讨。

Whether E2F1 can be used as a germinal center B cell DLBCL marker was also discussed .

但有关HRS细胞表型的研究表明，HRS细胞与其起源的生发中心B细胞在表型上有很大不同。

However , studies on phenotypes of HRS cells show that HRS cells are obviously different from its origin , B lymphocytes in germinal center in phenotypes .

淋巴结反应性增生中生发中心B细胞胞质大量表达bcl蛳10，边缘区中等量表达，在套区B细胞较少表达；

In activited lymph follicles , cytoplasmic expression of bcl - 10 protein was abundantly in the germinal center B cell , moderately in the marginal zone , and rarely in the mantle zone B cell .

CIL出现中心母细胞及瘤巨细胞，向高度恶性淋巴瘤转化。

CIL that showed centroblastic cells and tumor giant cells transformed into high-grade malignant lymphoma .

结论心脏移植排斥反应中移植心肌细胞色素C、caspase-8和caspase-3表达均明显上升，Bcl-2基因转染抗心脏移植排斥反应中心肌细胞凋亡作用可能与其下调细胞色素C、caspase-8和caspase-3的表达有关。

Conclusion Bcl-2 gene transfer was able to decrease the expression of cytochrome C , caspase-8 and caspase-3 and to protect myocardial cells against apoptosis in mice heart transplantation rejection .

GCB型和non-GCB型分别来源于正常生发中心B细胞或活化的外周血记忆B细胞，具有独特的基因表达谱。

GCB type and non-GCB type is original from normal germinal B cell and activated peripheral B cell respectively , and they have different gene expression profiling .

目的：观察猫心肌缺血再灌注过程中心肌细胞膜Ca2＋－ATPase活力、肌浆网钙摄取能力、线粒体丙二醛及心肌ATP含量变化。

Objective : To observe the changes of myocardial Ca ~ ( 2 + ) ATPase activity and Ca ~ ( 2 + ) uptake during myocardial ischemia / reperfusion in cats .

目的研究遗传性高血压及左室肥厚过程中心肌细胞凋亡及特异性AT1受体拮抗剂缬沙坦对心肌细胞凋亡的影响，探讨高血压左室肥厚及心肌细胞凋亡的可能机制。

Objective To explore the pathogenic effect of myocardial apoptosis on heart hypertrophy and heart failure and to evaluate the anti-apoptotic effect of valsartan .

激光扫描共聚焦显微镜（LSCM）分析表明，SOD在细胞内呈从细胞中心到细胞膜浓度逐步下降的辐射分布特征。

Laser scanning confocal microscopic ( LSCM ) assay indicated that SOD were distributed in a regular way of decreasing SOD concentration from central to peripheral areas of the carrier cells .

结果在10例FL标本中，CathepsinD阳性信号较弱，位于瘤性滤泡生发中心树突状细胞浆内。

Results Cathepsin D was weakly expressed in the plasma of dendritic cells and histiocytes in the germinal centers of 9 out of 10 cases of follicular hyperplasia .

目的观察落新妇甙（Astilbin）对小鼠心脏移植急性排除反应中心肌细胞凋亡的抑制作用。

Objective To investigate the inhibitory effect on apoptosis of myocardial cells in mice heart transplantation rejection .

目的比较超极化停搏和去极化停搏对体外循环（CPB）中心肌细胞膜流动性变化的影响，评价超极化停搏液的心肌保护作用。

Objective To observe the influences of depolarized arrest and hyperpolarized arrest on alternation of fluidity of myocardial cell membrane during cardiopulmonary bypass ( CPB ) and evaluate the protective effects on myocardium of hyperpolarized arrest .

21例原发性中枢神经系统淋巴瘤中仅有3例CD56阳性，阳性瘤细胞呈小灶性或散在分布，阳性表达细胞均为中心母细胞。

And only 3 out of 21 cases of primary CNS lymphoma expressed CD56 . The positive neoplastic cells were piled up or distributed scattered , which were centroblastic cells .

结论IBT可能通过调节心肌细胞肌浆网钙泵活性以抑制高血压左心室肥厚过程中心肌细胞凋亡，从而逆转左心室肥厚。

Conclusion Irbesartan may inhibit the apoptosis of cardiac myocytes by regulating the activity of sarcoplasmic reticulum Ca ~ ( 2 + ) - ATPase in the progress of left ventricular hypertrophy in hypertension , and thus reverse left ventricular hypertrophy .

β受体信号系统对心力衰竭中心肌细胞凋亡的作用

β - Adrenergic Receptor Signaling in Mediating Myocardial Apoptosis in Heart Failure

体外循环中心肌细胞膜流动性变化的自旋标记研究

Spin Labelling Study on the Fluidity of Myocardial Cell Membranes During Cardiopulmonary Bypass