原发性胆汁性肝硬化

目的通过原发性胆汁性肝硬化患者肝组织和外周血单个核细胞Fas、FasL的表达，探讨Fas、FasL在原发性胆汁性肝硬化患者发病机制中的作用。

Objective To study the pathogenesis role of Fas and FasL in PBC patients , we expressed their Fas and FasL in liver tissues and PBMC .

目前原发性胆汁性肝硬化（PBC）的病因好像还不是很清楚，但研究显示，这种疾病的发生与免疫有关。

It seems that the etiology of PBC is still unknown at this point , but studies indicate that there is an immunological basis for the disease .

人源M2三联体靶抗原检测抗体诊断原发性胆汁性肝硬化

Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary billiary cirrhosis

目的：探讨自身抗体对原发性胆汁性肝硬化（PBC）患者的诊断应用价值。

Objective : To study the role of auto-antibody in the diagnosis of patients with PBC .

目的：总结原发性胆汁性肝硬化（PBC）患者的临床及肝组织病理特征，以提高对本病的认识。

Objective : To explore the clinical and pathological features of primary biliary cirrhosis ( PBC ) .

系统性红斑狼疮（SLE）和原发性胆汁性肝硬化（PBC）是自身免疫性疾病的两种不同类型，是由于T细胞亚群比例失调，体内Th1/Th2细胞之间比例失衡。

Systemic Lupus Erythematosus ( SLE ) and Primary Biliary Cirrhosis ( PBC ) are two different types of autoimmune diseases .

单核细胞对原发性胆汁性肝硬化患者体内特定的TLR配体反应性的改变

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

目的分析原发性胆汁性肝硬化（Primarybiliarycirrhosis，PBC）的临床特点、常伴疾病及治疗反应，提高对PBC的认识和治疗水平。

Objective In order to facilitate our recognition of primary biliary cirrhosis ( PBC ), we studied PBC 's clinical features , main concomitant diseases and the responses to therapy .

目的原发性胆汁性肝硬化（PBC）的最重要特征为血清抗线粒体抗体（AMA）阳性，但少数PBC病例AMA阴性。

Objective Primary biliary cirrhosis ( PBC ) is characterized by frequent presence of anti mitochondrial antibody ( AMA ) .

目的建立检测人增殖诱导配体（APRIL）mRNA的实时荧光定量PCR方法，探讨外周血单个核细胞APRILmRNA表达水平与原发性胆汁性肝硬化（PBC）的相关性。

Objective To establish fluorescent relative-quantification polymerase chain reaction for detecting a proliferation-inducing ligand ( APRIL ) mRNA and to explore the association of its expression level with pathogenesis of primary biliary cirrhosis ( PBC ) .

目的对原发性胆汁性肝硬化（PBC）合并肺动脉高压（PAH）患者的临床和预后进行分析，提高临床对PBC的诊治水平。

Objective To analyze the clinical features and prognosis of patients with primary biliary cirrhosis ( PBC ) complicated by pulmonary arterial hypertension ( PAH ) .

背景：自身免疫性肝病包括自身免疫性肝炎（AIH）、原发性胆汁性肝硬化（PBC）和原发性硬化性胆管炎（PSC）等。

Background : Autoimmune liver diseases include autoimmune hepatitis ( AIH ), primary biliary cirrhosis ( PBC ) and primary sclerosing cholangitis ( PSC ), etc.

目的用重组表达的丙酮酸脱氢酶复合物E2亚单位（PDC-E2）检测M2抗体，以利于原发性胆汁性肝硬化（PBC）的早期诊断。

Objective To detect anti-M2 autoantibody using recombinant pyruvate dehydrogenase complex E2 ( PDC-E2 ) in order to help diagnosis of primary biliary cirrhosis ( PBC ) .

原发性胆汁性肝硬化PDC-E2特异性T细胞拮抗性模拟肽的筛选

Screening of analogue peptides antagonizing PDC-E2 specific T cells in patients with primary biliary cirrhosis

结论：早期原发性胆汁性肝硬化缺乏临床表现，ALP、GGT增高和AMA阳性是早期原发性胆汁性肝硬化的主要表现和诊断依据。

CONCLUSION : Early PBC lacks clinical manifestations , and increases of ALP , GGT , positive status of AMA are the main evidence for its diagnosis .

目的了解抗线粒体M2亚型抗体（AMA-M2）阳性原发性胆汁性肝硬化（PBC）患者自身抗体的种类和临床意义。

Objective To understand the type and clinical significance of anti-autoimmune antibodies in patients with anti-mitochondria ⅱ antibody ( AMA-M2 ) positive primary biliary cirrhosis ( PBC ) .

目的探讨抗线粒体亚型（AMA亚型）对原发性胆汁性肝硬化（PBC）的诊断价值。

Objective To explore the diagnostic value of anti-mitochondrial antibody subtype ( AMA-M2 , M4 and M9 ) in the patients of primary biliary cirrhosis ( PBC ) .

原发性胆汁性肝硬化AMA-M2阴性患者的临床及病理特点

Clinical and pathological features of primary biliary cirrhotic patients with negative anti-mitochondria antibody M_2 subtype

原发性胆汁性肝硬化（PBC）的，是肝硬化的早期形式，是一项长期的渐进自身免疫性疾病，在这过程中环境因素被认为是发挥作用的。

Primary biliary cirrhosis ( PBC ), which is an early form of liver cirrhosis , is a long term progressive autoimmune disease , in which environmental factors are thought to play a part .

目的定量检测原发性胆汁性肝硬化（PBC）患者体内抗原特异性T淋巴细胞含量，探讨其在PBC发病机制中的作用。

AIM : To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis ( PBC ) and study the role of antigen specific T lymphocytes in the development of PBC .

自身免疫性肝炎和原发性胆汁性肝硬化患者Fas-670基因多态性检测

The relationship of Fas-670 polymorphisms with autoimmune liver disease hepatitis and primary cirrhosis

背景：一般认为血清抗线粒体抗体M2亚型（AMA-M2）阳性是诊断原发性胆汁性肝硬化（PBC）的必备标准，但仍存在一定比例的AMA-M2阴性PBC患者。

Background : Serum antimitochondrial antibody-M2 ( AMA-M2 ) is considered to be a prerequisite for the diagnosis of primary biliary cirrhosis ( PBC ), however , there are a portion of AMA-M2-negative PBC patients .

大量的临床研究表明UDCA对多种胆汁淤积性肝病如原发性胆汁性肝硬化、原发性硬化性胆管炎和肝内胆汁淤积症等具有显著的疗效。

A large number of clinical studies show that UDCA have a significant healing effect on a variety of cholestatic liver disease , such as primary biliary cirrhosis , primary sclerosing cholangitis , intrahepatic cholestasis .

方法1996&1998年收治62例自身免疫性肝病，比较原发性胆汁性肝硬化（PBC）、自身免疫性肝炎（AIH）的临床症状、体征、生物化学指标及病理特征。

Methods Sixty-two patients with autoimmune hepatopathy were studied between 1996 and 1998 to compare primary binary cirrhosis ( PBC ) and autoimmune hepatitis ( AIH ) in the clinical symptoms , signs , laboratory findings and histologic features .

目的用重组丙酮酸脱氢酶复合物E2亚单位和E3结合蛋白（PDCE2，PDCE3BP）建立筛查原发性胆汁性肝硬化（PBC）患者相应自身抗体的ELISA。

Objective To develop an ELISA Kit by using prokaryotic expressed products for screening the autoantibodies to binding protein of E2 and E3 subunits ( E2BP and E3BP ) of pyruvate dehydrogenase complex ( PDC ) in the primary biliary cirrhosis ( PBC ) patients .

原发性胆汁性肝硬化85例实验室检测指标的分析

Analysis of laboratory parameters in 85 patients with primary biliary cirrhosis

原发性胆汁性肝硬化的早期自身抗体谱与临床预后的关系

Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis

58例原发性胆汁性肝硬化患者抗线粒体抗体和抗核抗体的特征分析

An analysis of autoantibodies characteristics in 58 patients with primary biliary cirrhosis

原发性胆汁性肝硬化比较蛋白质组学的基础与临床研究

Comparative Proteomics Analysis of Primary Biliary Cirrhosis : Basic and Clinical Research

原发性胆汁性肝硬化肝内小胆管的超微病理学研究

The Ultrastructure of Intrahepatic Bile Ducts in Primary Biliary Cirrhosis