大黄酸

HPLC法可测定出大黄酸的含量。

The content of rhein could be determined by HPLC .

结论：大黄酸对TNFα所致胰腺细胞损伤有明显的保护作用。

Conclusion : It is demonstrated that Rhein can effectively reduce toxic effects of TNF α on pancreatic acinar cells .

采用MTT比色法、流式细胞术分别检测大黄素和大黄酸作用下，前体脂肪细胞增殖力、细胞周期的变化以及细胞凋亡情况。

MTT spectrophotometry and cell cycle was assayed by FCM ( flow cytometry ) was adopted .

目的：建立测定大鼠血浆中大黄酸浓度的HPLC荧光检测方法，并对大黄酸在大鼠体内的药代动力学行为进行研究。

AIM : To establish a RP-HPLC-fluorescence method for the determination of rhein in plasma and to study pharmacokinetics of rhein in rats .

目的：探讨大黄酸是否对肿瘤坏死因子α（TNFα）作用下的胰腺细胞具有保护作用。

Objective : To study whether Rhein can reduce toxic effects of tumor necrosis factor alpha ( TNF α) on pancreatic acinar cells .

目的建立利胆合剂中环烯醚萜苷类（龙胆苦苷）和蒽醌类（大黄素、大黄酸）的薄层色谱鉴别方法（TLC法）。

Objective To establish the TLC identification method for iridoid glycosides ( gentiopicrin ) and anthraquinone ( emodin , rhein ) in Lidan mixture .

大黄酸衍生物RH-01对鼻咽癌KB细胞生长抑制的研究

Effect of rhein derivative RH-01 on growth of KB cells

目的研究大黄酸衍生物RH-01对鼻咽癌KB细胞的抑制作用。

Objective To study the effects of rhein derivative RH-01 on KB cells .

目的通过观察大黄酸对葡萄糖转运蛋白1（GLUT1）基因转染系膜细胞（MCGT1）功能的影响，探讨大黄酸治疗糖尿病肾病（DN）的作用机制。

Objective To evaluate the effect of rhein on the overexpression of glucose transporter 1 ( GLUT 1 ) in mesangial cells transfected with GLUT 1 gene in vitro .

结果：大黄酸可提高相应肿瘤坏死因子浓度下的胰腺细胞的细胞活率，降低培养上清中LDH、AMY和NAG的水平。

RESULTS : The study shows the rhein can appreciably increase the survival rate of acinar cell and lower the levels of LDH , AMY and NAG in the supernatant .

此外，检测细胞培养上清液中的纤维素增生（FN）含量。[~3H]脯氨酸掺入以及细胞胶原IV及FnmRNA的表达以观察大黄酸对细胞外基质的影响。

In addition , the [ 3H ] proline incorporation , level of fibronectin ( FN ) in supernatant , and mRNA expression of collagen IV and FN were also detected in rhein treated cells .

该类衍生物与钙调素（calmo-dulin，CaM）依赖的磷酸二酯酶（PDE）的相互作用表明：它们可作用子钙调素。其中，大黄酸结合CaM并抑制CaM依赖的磷酸二酯酶（CaM-PDE）；

Studies on the interaction between these derivatives and calmodulin-dependent phosphodiesterase ( CaM-PDE ) showed that anthraquinone derivatives could act with calmodulin ( CaM ) . Hypotensive Action of the Seeds of Chinese Parasoltree ( SCP )

RHL抑制乳腺癌细胞和卵巢癌细胞的增殖，并且在抑制肿瘤细胞增殖方面与大黄酸相近。

RHL inhibited the proliferation of breast cancer and ovarian cancer cells and had the same potency with rhein .

结果：在得到的200mL三黄泻心汤中含黄芩苷1211mg，小檗碱276mg，大黄酸25mg。

Result : There were baicalin 1 211 mg , berberine 276 mg and rhein 25 mg in 200 mL Sanhuang Xiexin decoction .

在大鼠体内，甘草酸及其代谢产物均加快了大黄酸的代谢，诱导肝药酶P450，而且甘草酸的代谢产物甘草次酸对大黄酸的抑制超过了甘草酸。

In rats , glycyrrhizic acid and its metabolites act as inducers of hepatic drug metabolizing enzyme P450 , rhein accelerated the metabolism of glycyrrhizin and glycyrrhetinic acid metabolites of rhein inhibition on more than glycyrrhizin .

甲醇-0.1%H3PO4为流动相，梯度洗脱，检测波长为270nm，以大黄酸为参照峰。

UV detection wavelength was 270 nm , and rhein was used as a reference peak .

结果显示，大黄酸和大黄素对线粒体中ROS的产生均有很强的抑制作用，因此，阻断线粒体中活性氧的产生可能是该物质治疗糖尿病并发症的机制之一。

The result showed that ehein and emodin can suppress the ROS in the mitochondrial . It indicate that the inhibition of the reactive oxygen species generation in the mitochondrial may be one of the mechanisms of the treatment of diabetic complication .

大黄酸对葡萄糖转运蛋白1基因转染系膜细胞功能的影响

Inhibition of glucose transporter 1 overexpression in mesangial cells by rhein

大黄酸对2型糖尿病肾病大鼠疗效观察

Rhein retards the progression of type 2 diabetic nephropathy in rats

大黄酸-雌激素偶联物的合成及其药理学活性

Synthesis and pharmacological activities of a series of estrogen-rhein hybrid compounds

大黄酸诱导肿瘤细胞凋亡及与丝裂霉素的协同作用

Rhein induces apoptosis in cancer cells and shows synergy with mitomycin

分子印迹-固相萃取法选择性分离大黄酸的研究

Selective Separation of Rhein by Molecular Imprinting Polymer and Solid-phase Extraction

大黄酸对输尿管梗阻大鼠肾组织纤维化的保护机制

Protection Mechanisms of Rhein on Rat Kidney Fibrosis with Unilateral Ureteral Obstruction

大黄酸对人前体脂肪细胞增殖与分化的影响

Effects of Rhein on proliferation and differentiation of human preadipocytes

大黄酸对db/db小鼠糖尿病肾病疗效的观察

Therapeutic effect of rhein on diabetic nephropathy in db / db mice

方药配伍对茵陈蒿汤中大黄酸提取率变化的影响

Influence of Drug Compatibility on Extractive rate of rhein of Yinchenhao Tang

大黄酸精氨酸对术后肠粘连的防治作用及机制研究

Protective Effect and Mechanism of Rhein-Arginine on Postoperative Intestinal Adhesions

目的：采用猪血清免疫损伤性大鼠肝纤维化模型，观察大黄酸抗肝纤维化的效应并探讨其可能机制。

OBJECTIVE : Adopt immunological hepatic fibrosis induced by porcins serum in rats .

大黄酸对低剂量链脲佐菌素肥胖糖尿病大鼠糖尿病肾病的影响

Rhein improves diabetic nephropathy in obese diabetic rats induced by low dose streptozotocin

大黄酸对白细胞介素-6诱导的血管平滑肌细胞增殖的影响

Effects of rhein on proliferation of vascular smooth muscle cells induced by Interleukin-6