应激原

寒冷是高寒地区动物和人的一种常见应激原。急性（短期）暴露于寒冷环境的动物将产生冷应激（Coldstress）反应。

Cold stress would be developed in the animals exposed to coldness which is a common stressor for animals and human in cold environment .

它是一种非特异性应激原，它可诱导机体产生应激反应。

It is a non-specific stressor ; it may induce a stress response .

方法通过对BalbC小鼠连续4周施加7种应激原，建立慢性轻度应激动物模型。

Methods A chronic mild stress animal model was established by subjecting BALB / c mice to a stressful regimen arranged in an unpredicted manner for 4 consecutive weeks .

热休克蛋白（Heatshockproteins，HSPs）是在机体受到应激原的刺激后产生的几族蛋白质，具有高度保守性，对维持细胞生存和内环境的稳定起重要作用。

Heat shock proteins ( HSPs ) are several families of proteins which organisms synthesize by inducing of stressors . HSPs are highly conserved , and play a important role in the survival of stressed cells and stabilization of internal environment .

以鸡新城疫（ND）Ⅰ系疫苗作为免疫应激原，给T组雏鸡肌肉接种2头份/（mL·只），诱发免疫应激；C组不做任何处理。

Newcastle Disease ⅰ Series ( ND ⅰ) was taken as the source of immunological stress ; the muscles of chicken group T were inoculated with 2 dose per chicken to induce immunological stress , and group C wasn ′ t given any treatment .

结论：脑低灌对脑CPK活性和外周血乳酸、血糖、肝LDH均有抑制作用，BH－2A是一种应激原可损伤肠屏障导致EnET入侵。

CONCLUSIONS : BH-2A have prohibitory effect on brain CPK , peripheral blood lactate and liver LDH . BH-2A is a stress factor that can injury the entero-barrier and cause invasion of EnET .

采用垂直旋转、睡眠剥夺、噪音刺激和夜间光照4种应激原，无规律地交替刺激动物6周，每天6h，制作慢性复合应激动物模型。

Rats in the stressed group were irregularly and alternately exposed to the situation of vertical revolution , sleep deprivation , noise stimulation , and night illumination 6 h per day for 6 weeks to prepare a chronic multiple stressed model .

复方中药制剂抗冷应激原作用及其机制的研究

Effects and Mechanisms of the Traditional Chinese Medicine on Improving Cold-stress-resistance

由于手术应激原影响，外科大手术围术期发生应激性高血糖屡见不鲜。

Influenced by the surgical stressor , stress-induced hyperglycemia is very common in the perioperative period .

手术作为一种心理应激原，常可导致患者产生比较强烈的应激反应。

As one of psychological stressors , the surgery often leads patients to acute stress reaction [ 0 ] .

在辅助生育治疗过程中减少应激原，降低焦虑情绪，可提高治疗的成功率。

To reduce stressors and anxiety mood in the course of assistant procreation can raise the success rate of IVF-ET therapy .

寒冷是北方寒区动物最普遍的应激原，寒冷应激所引起的动物生长缓慢、抗病性差、甚至死亡是制约北方畜牧业和养殖业发展的主要因素之一。

Cold stress , which causes animal slow-growing , poor disease-resistance , even death , can lead to significantly economic loss and restrict the development of northern animal husbandry .

结论1.高考，刑事拘留，睡眠剥夺均可以作为应激原而引起心理方面的改变，本文的研究人群可以作为应激的研究对象。

Exam , Criminal detainees , Sleep deprivation can be as stressors to change the psychology and the study population of this article can be as the object of stress study . 2 .

而MAPK在由多种应激刺激原或炎症因子激活的信号通路中扮演重要角色，并介导细胞生理病理改变，但其在KIM-1裂解功能上的意义尚见报道。

MAPK plays an important role in signal transduction pathways activated by multiple stressors or inflammatory factors , and mediates physiological and pathophysiological changes in cell function . However , the role of MAPK in KIM-1 cleavage function is still unclear .

其受体和非受体酪氨酸激酶途径受金属离子、细胞因子、氧化应激、原癌基因等的调节。

These pathways including receptor and non-receptor tyrosine kinase pathways are mediated by metallic cations , cytokines , oxidative stress , oncogene / pro-oncogene etc.

目的探讨caspase-12表达变化与内质网应激介导小鼠原代肝细胞凋亡的关系。

Objective To investigate the relationship between caspase-12 activation and ER stress mediated apoptosis of primary mouse hepatocytes .

复合应激组动物每天交替暴露于复合应激原环境（睡眠剥夺、垂直旋转、噪音刺激和持续光照）中达6周，对照组动物不干预。

The rats in multiple stress group were alternatively exposed to the situation of complex stressor every day ( sleep deprivation , vertical conbolution , noise stimulation and continuous illumination ) for 6 weeks . Those in control group were without intervention .

以往的慢性应激导致记忆受损的实验动物模型通常采用单一应激原，例如捆绑、电击、致痛，睡眠剥夺或噪音等。

Such single stressor as restraint , foot shock , induced pain , sleeping deprivation or noise , which impaired learning and memory has been applied to make animal models in the past .

应激（stress）或应激反应（stressreaction）是机体受到应激原刺激而作出的全身适应性应答，借以维持体内环境的稳定。

Stress or stress reaction is a kind of general physical and adaptive response during the body is stimulated by a stressor .

有规律的运动（如抗阻训练）可以减少由于增龄性氧化应激对骨骼肌DNA的损伤作用，而运动作为一种应激原对于基因表达也能起到调节的作用。

Regular exercise ( mainly in resistance training ) can be reduced oxidative stress to damage DNA with age-related , exercise also play a role in regulation stress gene expression .