异种器官移植

目的：构建含杂合增强子UI的人衰变加速因子（DAF）重组基因的表达载体，应用于转基因动物克服异种器官移植排斥反应的研究。

Objective : To construct the recombinant human decay accelerating factor gene using UI enhancer for high-performance expression in xenotransplantation .

但是，最近在规避宿主脑部免疫排斥方面取得的进展，对于开展恢复性脑异种器官移植策略是一个极大的鼓舞。

However , recent progress to circumvent the host immune response in the brain has raised encouraging perspectives for intracerebral xenotransplantation as restorative strategy .

修饰CⅡTA基因抑制异种器官移植中供体猪SLA的表达

Depression of the expression of swine leukocyte antigen by modification of C ⅱ TA gene in the xenotransplantation

异种器官移植（Xenotransplantation，XT）是未来生物学科中的重要研究领域之一。

Xenotransplantation is one of the important biological research fields .

异种器官移植用血管内皮细胞特异表达人DAF重组基因载体的构建

Construction of Recombinant Human Decay Accelerating Factor for Endothelial-specific Expression in Xenotransplantation

衰变加速因子（DAF）与异种器官移植免疫

Decay acceleration factor ( DAF ) and immunology in xenotransplantation

人HT、DAF和CD59基因联合转基因小鼠的制备及其抗异种器官移植免疫排斥反应的研究

Production of Triple-transgenic Mice Expressing Human HT 、 DAF and CD59 Gene and the Studies of These Transgenes in Xenograft Rejection

异种器官移植面临的免疫学障碍表现为超急性排斥（HAR），急性血管排斥反应（AVR），细胞介导的排斥反应和慢性排斥反应。

Xenotransplantation faces several immunologic barriers : hyperacute rejection ( HAR ), acute vascular rejection ( AVR ) and chronic rejection mediated by cell .

目的通过建立转人衰变加速因子（DAF）基因小鼠，为研究异种器官移植的超急性排斥反应提供有效的研究手段。

Objective To develop transgenic mice carrying human decay accelerating factor ( DAF ) to provide an effective method for the study on xenogeneic hyperacute organ rejection .

进行异种器官移植需要解决种间免疫排斥反应（HAR，DXR和TMR）及猪的内源性逆转录病毒（PERV）的问题。

Immuno_rejection , as well as the potential risk of inadvertent transfer of porcine endogenous retroviruses ( PERV ), are the major barriers in xenotransplantation .

异种器官移植的发展与医学伦理学思考

The Development of Xeno - transplantation and Medical Ethical Reflection

猪作为异种器官移植供体的研究进展

The recent progress of swine as organ donors in xenotransplantation

猪是人异种器官移植理想的器官来源。

Pigs are considered as ideal organ donor for human future xenotransplantation .

转基因克隆猪与人类异种器官移植

Genetical Modification of Porcine Organs for Human in Xenotransplantation

异种器官移植的基础研究和技术发展已经成为当前器官移植学的新领域。

The basic research and development of xeno-transplantation technique has been a new field .

目前应进一步加强异种器官移植的基础研究。

At present time the basic research of xenogeneic transplantation should be mainly emphasized .

异种器官移植转基因猪检测系统的建立

The foundation of xenotransplantation transgenic pig detection system

异种器官移植：前景如何？

How are the Prospects for Xenotransplantation ?

接受异种器官移植的病人，由于自身抵抗力低，极易遭受疾病的侵袭。

Patients undergoing xenotransplantation will be especially vulnerable , because their natural defences are down .

克服异种器官移植排斥反应的对策

The approaches for overcoming rejection in xenotransplantation

此外，还探讨了建立健全异种器官移植的法律法规的重要性。

Besides , the article explored the importance of setting up laws and regulations about xeno-transplantation .

补体调节因子在异种器官移植中的作用

Role of complement regulators in xenotransplantation

因此，全世界的科研人员正在寻求防止异种器官移植时排异反应的方法。

So researchers the world over are seeking ways to get around the rejection reactions for xenotransplants .

关于异种器官移植的问题

On the Xenogeneic Transplantation

超急性排斥反应一直是异种器官移植中的主要障碍之一，其分子基础是补体及其激活。

Hyperaction rejection ( HAR ), based on the activation of complement molecules , has always been one of obstacles in xenotransplantation .

超急免疫排斥反应被视为是异种器官移植中最具挑战性的障碍。

Hyperacute rejection ( HAR ) has been viewed as the most challenging barrier to the xenotransplantation of vascularized grafts between different species .

猪在人类疾病动物模型、新药安全性有效性评价、异种器官移植供体等领域均显示出独特优势。

Pigs show unique advantages in the aspects of animal models about human diseases , the effectiveness and security evaluation of new drugs and the donation of xenotransplantation .

心、肝、肾功能代谢、血液生理生化指标和器官大小近似人类，是理想的动物模型和人类异种器官移植供体。

Its heart , liver , Kinney , physiological and biochemical index of blood and organ size are similar to human , which is a kind of ideal animal model and heterogeneity organic transplant recipient of human .

转基因动物技术在建立动物模型，研究基因功能，治疗人类疾病，动物抗病育种，异种器官移植和生物制药等许多方面都具有广泛的应用价值。

Transgenic animal technology have a wide range of applications in the establishment of animal models to study gene function and treatment of many human diseases , animal breeding for disease resistance , xenotransplantation , biological pharmacy .

通过对小型猪培育的现状与前景、以及小型猪在胚胎生物工程领域的应用进行综述，重点介绍异种器官移植和转基因猪生产。

This article mainly describes the current status and prospects of the breeding of laboratory mini-pigs . The application of mini-pigs to embryO bio-engineering is reviewed , and the xenotransplantation and the production of transgenic pig are stated mainly .