抗肿瘤血管生成

抗肿瘤血管生成及其联合放化疗的研究进展

Advances in anti-tumor angiogenesis and combinated with radiotherapy or chemotherapy

由此推论六神丸不仅对恶性肿瘤细胞具有直接杀灭作用，亦可以通过RAS系统抗肿瘤血管生成途径等多角度实现抗肿瘤作用。

It seems therefore that Liushen pill have a direct role to kill the malignant cells , may also , through the RAS system , anti-tumor angiogenesis approaches realize the perspective of many anti-tumor effects .

抗肿瘤血管生成药物恩度在非小细胞肺癌中的临床应用与血清VEGF水平测定的研究

Clinical Research of Anti-angiogenesis Drug Recombinant Human Endostatin to Determine Serum VEGF in Non-small Cell Lung Cancer

因此，VEGF被认为是抗肿瘤血管生成药物开发的理想靶标。

Based on these evidences , VEGF is considered as a rational target for antiangiogenic drug development .

结论MPA对孕激素受体阳性/阴性癌组织诱导血管形成有明显抑制作用。MPA抗肿瘤血管生成作用与孕激素受体无关。

Conclusion MPA has inhibitory effect on neovascularization induced by carcinoma tissues whether PR positive or negative .

针对VEGF的抗肿瘤血管生成的治疗已取得了很大进展，包括应用VEGF抑制剂、腺病毒介导的基因治疗等。

The anti-angiogenesis treatments aimed at VEGF , including the applications of VEGF inhibitor and gene therapy of adenovirus medium , had got great progress .

目的构建人骨骼肌TnIfast基因分泌型真核表达载体，为利用TnIfast基因进行抗肿瘤血管生成基因治疗奠定基础。

Objective To construct a recombinant eukaryotic expression plasmid encoding human fast twitch skeletal muscle troponin I gene ( TnI fast ) for anti angiogenesis in tumor gene therapy .

检测VEGF及其受体KDR的联合表达对进一步了解宫颈癌血管生成情况以及寻找抗肿瘤血管生成治疗新靶点有一定价值。

Detection of co-expression of VEGF and KDR may be of value in further understanding tumor angiogenesis and searching new target for anti-angiogenesis therapy in invasive carcinoma of cervix .

腺相关病毒载体介导的Endostatin及K1-5蛋白抗肿瘤血管生成协同作用

Synergy of antiangiogenesis for tumor via adeno - associated viral vector - mediated gene transfer of endostatin and K1-5

抗肿瘤血管生成：肺癌治疗新希望&2006年ASCO新进展

Anti-angiogenesis of cancer : A new hope for lung cancer & The advances in American Society of Clinical Oncology 2006

VEGF和VEGFR因其在肿瘤血管生成中的重要作用而成为抗肿瘤血管生成疗法的重要靶点。

Vascular endothelial growth factor ( VEGF ) and vascular endothelial growth factor receptor ( VEGFR ) have become a crucial target of anticancer therapy because of their functions of anti-angiogenesis .

背景与目的：上世纪70年代由JudahFolkman提出的有关肿瘤血管生成的理论已被广泛接受，目前，抗肿瘤血管生成已经成为肿瘤学基础研究及临床治疗领域中最有前景的策略之一。

Background and Objective : The theory of tumor angiogenesis first presented by Dr Judah Folkman in 1970s has been accepted widely , and today anti-angiogenesis has become one of the most exciting and visible areas in cancer research and therapeutics of clinical oncology .

斑马鱼在抗肿瘤血管生成研究中的应用

The Application of Zebrafish in the Study of the Tumor Antiangiogenesis

脑胶质瘤的抗肿瘤血管生成治疗新进展

Advance in Research of Antiangiogenic Therapy for Glioma in Brain

血管抑素抗肿瘤血管生成机制的实验研究

Study on the Mechanism of Angiostatin in Antiangiogenesis of Tumor

小剂量奥沙利铂抗肿瘤血管生成作用的体内实验研究

An Experimental Study of Low Dose Oxaliplatin Inhibiting Tumor Angiogenesis in Vivo

抗肿瘤血管生成剂临床试验的循证思考

Evidence based thinking for clinical trials of anti-tumor-angiogenic agents

抗肿瘤血管生成的靶点研究概况

Progress in the Study of Antitumor Angiogenesis Targets

血小板第四因子抗肿瘤血管生成研究进展

Research Progress in Anti-tumor Angiogenesis of Platelet Factor-4

本文对近年来抗肿瘤血管生成药物的研究进展做一综述。

We summarized recent researches about the development of tumor angiogenesis inhibitors in this review .

~（99）Tc~m-血管抑素在荷乳腺癌小鼠体内抗肿瘤血管生成的治疗效应

~ ( 99 ) Tc ~ m-angiostatin for inhibiting neovascularization in mice bearing breast cancer

目前尚未发现有关姜黄素Ⅲ抗肿瘤血管生成作用体内实验方面的研究报道。

The effect of curcumin ⅲ on angiogenesis in vivo has not been showed in literature .

人直肠癌组织中脑特异性新生血管抑制因子1表达及该因子抗肿瘤血管生成作用的观察

Expression of brain - specific angiogenesis inhibitor 1 in human rectal cancer tissues and its effect on tumor angiogenesis

并能够通过抗肿瘤血管生成抑制高转移性人肝癌切除术后的复发转移。

Octreotide dose-dependently inhibited recurrence and metastasis of HCC after curative resection in nude mice through inhibition of angiogenesis .

本研究通过体内和体外实验从这三条途径分别对力达霉素抗肿瘤血管生成的活性和机理做了一些探讨。

This study investigated the anti-angiogenesis effect of LDM and its mechanisms both in vitro and in vivo . 1 .

实验研究和临床实践表明，肝癌是富血管肿瘤，抗肿瘤血管生成治疗具有重要价值。

Experimental research and clinical practice shows that as a rich vascular tumor , anti-angiogenesis is therapy is of great value for liver cancer .

彩色超声多谱勒以及免疫组化结果发现联合治疗组比单药治疗组具有更高的肿瘤坏死率和更强的抗肿瘤血管生成作用。

CDFI and immunohistochemistry showed that there were significantly higher tumor necrosis rate and stronger anti-angiogenic effects in combined therapy group than single agent group .

有研究表明应用传统的化疗药物小剂量长期治疗同样具有抗肿瘤血管生成作用，而且没有毒副作用。

Studies have shown that traditional low-dose chemotherapy for a long time has the same effect on the treatment of anti-angiogenesis but no toxic side-effects .

抗肿瘤血管生成，是肿瘤生物治疗的重要靶点。开发新的，有效的抗肿瘤血管生成药物是该领域的研究热点。

Antiangiogenesis in cancer is the vital target in tumor biological therapy , developing of new efficient antineoplastic agents is always the hot-point in this field .

在明确其抗肿瘤血管生成机制的基础上，筛选合理的用药模式来指导临床应用，会产生很好的社会效应与经济价值。

Therefore , after making clear their anti-tumor angiogenesis mechanism and screening reasonable drug application mode , they could bring enormous social impact and economic value .