曲尼司特

结论曲尼司特能明显抑制小梁细胞TGFβ2的表达。

Conclusion Tranilast could inhibit TGF - β _2 expression in cultured human trabecular meshwork cells .

曲尼司特对正常皮肤和瘢痕疙瘩Fb的形态学影响相似。

Tranilast had the similar effects on the morphology of normal and keloid fibroblasts .

RP-HPLC法测定复方曲尼司特片中硫酸沙丁胺醇的含量

Determination of Salbutamol Sulfate in Compound Tranilast Tablets by RP-HPLC

曲尼司特能抑制正常皮肤和瘢痕疙瘩成纤维细胞Ⅰ、Ⅲ型前胶原mRNA表达，且随着浓度增加这种作用越加明显。

Tranilast could reduce the synthesis of procollagen ⅰ / ⅲ mRNA in normal and keloid fibroblasts . The inhibition ability became more evident when the concentration was increased .

目的：研究曲尼司特对正常皮肤和瘢痕疙瘩成纤维细胞转化生长因子-β1（TGF-β1）、碱性成纤维细胞生长因子（bFGF）和白介素-6（IL-6）表达的影响。

Objective : To explore the effects of tranilast on production of TGF - β 1 , bFGF and IL-6 in normal and keloid dermal fibroblasts .

方法：以可降解生物聚合物PLGA为涂层材料，制备曲尼司特洗脱支架，考察其物理化学性能和药物的释放行为。

Methods : TES was coated with a biodegradable polymer PLGA , and its release profile and other physics & chemical behaviors were evaluated .

MTT法检测显示，加入不同浓度曲尼司特后，正常皮肤和瘢痕疙瘩成纤维细胞的OD值较对照明显降低，差异有统计学意义（P＜0.05）。

MTT test demonstrated significant decreases of OD value in normal and keloid fibroblasts when added with various concentrations of tranilast . Compared with the control group , the difference had statistical significance ( P0.05 ) .

采用半定量逆转录聚合酶链反应（RT-PCR）观察曲尼司特滴眼液对兔眼Tenon囊组织α2（Ⅰ）链前胶原及TGF-β1mRNA表达的影响。

Alpha 2 (ⅰ) procollagen and TGF - β _ ( 1 ) mRNA in rabbit Tenon 's capsule were detected by reverse transcriptase-polymerase chain reaction ( RT-PCR ) analysis .

药物组口服曲尼司特胶囊，0.2g口服，每日3次，连续7日。

A control group was treated by oral administration of Tranilast capsule , 0.2 g three times daily , for 7 consecutive days .

随着曲尼司特的浓度增加，其OD值逐渐呈下降趋势，提示成纤维细胞生长受抑。

With the increase of tranilast concentration , OD value gradually decreased , which suggested the inhibition effects on fibroblasts growth . Consequently , the levels of mRNA for procollagen type ⅰ and type ⅲ were determined by RT-PCR .

方法按照Bennett等报导的方法，将36只大鼠分为两组：实验组在整个实验过程中，每日经口给予曲尼司特200mg/kg，对照组每日给予药物溶剂10ml/kg。

Methods 36 rats were divided into 2 groups : one was treated with tranilast ( 200mg / kg · d-1 , p.o every experimental day ), the other was controlled with solvent only .

相同条件下，曲尼司特缓释片在人工胃液、人工肠液和梯度pH溶液中，10h的释放度分别为0.72%、94.3%和98.7%。

The extensions of dissolution of tranilast from the SR matrix tablets , to their perfect extent were 0.72 % ( in SGF ), 94.3 % ( in SIF ) and 98.7 % ( in gradient pH ) within 10 hours .

结果：巴布剂最佳处方为：曲尼司特0.5g，聚乙烯醇6g，水溶性高分子材料25g，甘油5g，丙二醇5g，氮酮5g，蒸馏水加至150g；

Results : The best prescription of cataplasm is : tranilast 0.5 g , PVA 6 g , high molecular weight water-soluble material 25 g , glycerin 5 g , azone 5 g , propylene glycol 5 g , with water added to 150 g.

曲尼司特涂层支架的制备及体外释放度研究

Study on Release Profile of Tranilast From Tranilast-Eluting Stents in Vitro

曲尼司特抗大鼠肺纤维化的作用及机制

Inhibitory effects and mechanisms of tranilast on pulmonary fibrosis in rats

曲尼司特对豚鼠肺组织β肾上腺素受体向下调节的影响

The effect of tranilast on the down-regulation of beta - adrenoceptors

依巴斯汀联合曲尼司特治疗慢性荨麻疹疗效观察

The Efficacy of Ebastine Combined with Tranilast in treating Chronic Urticaria

曲尼司特对大鼠主动脉平滑肌细胞增殖的影响

Effect of tranilast on proliferation in rat aortic smooth muscle cell

曲尼司特抑制大鼠胸主动脉球囊损伤后再狭窄

Tranilast in preventing restenosis after rat thoracic aorta balloon injury

曲尼司特对正常皮肤成纤维细胞的影响大致相似。

In addition , Tranilast had the similar effects on normal fibroblasts .

曲尼司特胶囊治疗瘢痕疙瘩、增生性瘢痕疗效观察

Observation of Tranilast in Treating Keloid and Hypertrophic Scar

目的了解曲尼司特治疗慢性荨麻疹的临床疗效。

Objective To learn the curative effect of chronic urticaria treated with tranilast .

结论：复方曲尼司特胶囊是一种安全有效的平喘药。

Conclusion : Compound tranilast capsules is a safe and effective antiasthma drug .

结果：1.曲尼司特洗脱支架具有合适的药物释放行为和物理化学性能；

Results : 1 . TES manifested appropriate releases behavior and physical & chemical capability .

复方曲尼司特片人体药动学及生物等效性研究

Pharmacokinetics and Bioequivalence of Compound Tranilast Tablets

曲尼司特对实验性慢性阻塞性肺疾病气道重塑的干预慢性阻塞性肺病合并营养不良

Effect of tranilast on airway remodeling of experimental COPD rats MALNUTRITION COMPLICATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE

曲尼司特胶囊治疗特应性皮炎的多中心随机双盲对照研究

Treatment of atopic dermatitis with tranilast capsule : A multicenter , randomized , double-blind , placebo-controlled trial

目的：观察依巴斯汀联合曲尼司特治疗慢性荨麻疹的疗效。

Objective : To explore the clinical efficacy of Ebastine combined with Tranilast in treating chronic urticaria .

目的评价曲尼司特胶囊治疗特应性皮炎的安全性和有效性。

Objective To evaluate the safety and efficacy of tranilast capsule in the treatment of atopic dermatitis .

通过小型猪冠状动脉损伤模型，研究曲尼司特洗脱支架植入30天的有效性和生物相容性。

The feasibility , efficacy and biocompatibility of TES were investigated in the porcine coronary model after 30 days .