真皮层

变态前仔鱼的皮肤发育缓慢，1～25d仔鱼的皮肤由1～2层表皮细胞和不发达的真皮层组成。

The skin of 1-25 days old larvae developed slowly and was composed of the thin epidermis of 1-2 layers epidermal cells and undeveloped dermis before the metamorphosis .

创面修复过程中真皮层胶原纤维重构，排列趋于整齐。

Collagen remodeling and rearrangement in the dermis occurred during the progress of wound repair .

非治疗组真皮层中P物质免疫反应阳性神经纤维较正常增多（P<0.01），在真皮结缔组织中和小血管旁P物质阳性神经纤维明显增加，染色加深。

Dermis P-substance immunoreactive nerve fibers in non-treatment group were more than those in normal control group ( P < 0.01 ), with P-substance immunoreactive nerve fibers increased and deeply stained in dermis connective tissues and small vessels .

封闭负压引流后MMP-1在表皮角化层含量增加，真皮层变化不很显著；

More MMP-1 expressions were found in keratinocyte layer with no obvious changes in dermis after VAC .

以HPLC测定一定时间点接受室中药物浓度，求算累积渗透量及稳态透皮速率，并测定药物在表皮层和真皮层中的滞留量。

The concentrations of finasteride in receptor compartment at specified time points were determined by HPLC . The steady penetration rate and the quantity of drug accumulated in skin were calculated .

通过对各批样品H·E切片表皮层及真皮层厚度平均值的分析发现，蒙古绵羊的皮肤表皮层厚度变化是连续的，而且与季节周期有密切关系。

The analysis of average thickness of H · E stained skin samples showed that the epidermis thickness change of Mongolia sheep is a continuous process , and it have germane relationships with season cycle .

与模型组相比，预先涂以PCF和VC的小鼠皮肤受UVB辐射后，真皮层表达的Ⅰ型胶原减少。

Compared to model group , the dermal type I collagen expression decreases after the murine skin pre-painted with PCF and VC is exposed to UVB .

组织学观察显示，CS真皮层无皮肤附件，胶原纤维排列有序，仅有少量淋巴细胞浸润。

Light microscopy showed that there was no skin appendage , collagen fibers were lined up orderly , and only a small number of lymphocytes infiltrated into the CS dermal layer .

结果：极限扩张后皮肤真皮层明显变薄，表皮层厚度与RTE组相比无明显变化；

There were no significant different about the thickness of epidermis in ETE group and RTE group ;

NGF图像分析方法：①在400倍显微镜下分别观察各组表皮和真皮层中呈棕黄色的NGF阳性颗粒个数，并进行计数。

NGF image analysis method : ① NGF positive particles of each group were observed and count under the 400 times microscope in the layer of epidermis and dermis .

结果：给药组小鼠皮肤SOD活性明显增加，MDA含量明显降低，胶原蛋白含量明显增加，皮肤组织形态学检查结果与衰老模型组比较显示真皮层成纤维细胞数量增加，胶原纤维排列紧密，排列较规则。

Results : The SOD vigor and contents of collagen protein were significantly increased while the contents of MDA were decreased obviously . The histomorphology of skin tissue manifested that amount of the desmocyte in derma layer were increased and collagenous fibers were aligned tightly and regularly .

成体干细胞（ASC）作为早期未分化细胞具有强大的增殖更新及定向分化为成骨细胞、软骨细胞、神经细胞、脂肪细胞、骨骼肌细胞、真皮层细胞、肝细胞等的潜能。

Adult stem cells ( ASC ) as an early undifferentiated cells has the potential of strong self-renewal and proliferation and differentiated into osteoblasts , chondrocytes , nerve cells , adipocytes , muscle cells , dermal cells et al .

结论：通过静脉滴注ACV及外用3%ACV软膏，可有效阻止水痘带状疱疹病毒（VZV）内脏传播，阻止VZV感染到真皮层，可明显缩短病程，安全有效。

The intravenous perfusion of ACV plus 3 % ACV ointment for external use can prevent the chicken pox virus from spreading to internal organs and infecting the corium thereby shortening the disease course .

其组织病理特征：真皮层表达CD34的梭形细胞增殖并向下扩展到皮下脂肪组织，间质黏蛋白和弹性纤维轻度增加并伴弹性组织离解；

The skin-biopsy specimen shows a proliferation of CD34-expressing dermal fibrocytic spindle-cells which extend into subcutaneous fat , a slight increase of interstitial mucin and elongated elastic fibers with elastolysis . A colloidal iron stain reveals the deposition of a small amount of mucin in the superficial dermis .

结果酮基布洛芬经剥离角质层皮肤的Kp是完整皮肤的1.7倍，IPM能分布在真皮层并可明显增加药物在角质层的分布和经皮累积渗透量。

RESULTS The Kp of ketoprofen via stripped skin was about 1.7 times larger than that via intact skin . The permeability was enhanced when coexisting with IPM via either of the two layers and the distribution content of ketoprofen was significantly increased in the stratum corneum .

真皮层内皮肤附件结构、形态良好。

True cortex skin in attachment structure , shape is good .

真皮层胶原基质结构松散，成纤维细胞减少。

Dermal layer of loose collagen matrix structure changes , fibroblasts reduced .

组织病理学特征为真皮层大量胶原纤维沉积。

Histopathology showed increased dermal accumulation of collagen fibers .

真皮层可见呈波浪状均匀分布的纤维组织。

Wavy fibrous tissue uniformly distributed in dermis .

能抑制胶原蛋白酵素，避免肌肤真皮层中胶原蛋白的断裂，保护肌肤弹性。

Inhibits collagenase and protects the collagen of the inner skin to enhance elasticity .

结论：乌头直流电离子导入可明显提高佐剂性关节炎大鼠痛阈，治疗局部可见真皮层内毛细血管扩张。

Conclusion : Iontophoresis of aconitine will greatly lighten the hyperalgesia of the AA rats .

可调节看到皮肤真皮层色素的沉积部位，检测皮肤的老化程度等。

Adjustable lens allow us to see the pigment in the corium and the skin aging problem .

可激活真皮层中纤维母细胞，分泌胶原蛋白，改善因阳光所形成的老化问题。

Activates fibroblasts in the dermal layer to secrete collagen , inmroving aging problem caused by sunlight .

真皮层被一个纤维胶原网包在一起，而水份使其结实。

The dermis is held together by a fibrous net of collagen and kept firm by water .

切口类型和真皮层血管网的损伤是皮瓣坏死的根本原因。

Incision type and the trauma of blood vessel net in derma are the basic cause of skin flag necrosis .

结论：超声能够对皮下真皮层起到治疗作用，一定时间间隔的重复扫描不会引起皮肤的累积损伤。

Conclusions : Focused ultrasound has therapeutic effect on dermis but no accumulated damage to the skin treated at regular intervals .

鲜红斑痣是一种先天性起源于皮肤血管的良性肿瘤，病理表现为真皮层中的毛细血管扩张。

Port wine-stains are congenital benign tumor begin from skin vessels . It is characterized by the telangiectasias in dermal layer .

皮肤缺损创面的修复一直是外科领域不断深入研究的课题，而理想的创面愈合应含有真皮层结构。

Skin defect wound repairing is always topic studied deeply in surgical field , and ideal wound healing should contain dermal structure .

人们寻求各种治疗手段使皮肤真皮层更新，组织结构更优，表皮恢复正常。

People seek treatment so that the dermis updates , organizational structure can become better , and make epidermis return to normal .

目的：评价皮肤角质层和真皮层对药物经皮吸收的差异。

OBJECTIVE : To investigate the influence of skin layers ( stratum corneum and dermis ) on the percutaneous absorption of drug .