米诺环素

米诺环素对缺血-再灌注损伤皮层的保护作用及对caspase-3活性与表达的影响

Effects of Minocycline on Activity and Expression of Caspase-3 Induced by Focal Cerebral Ischemia Following Reperfusion

米诺环素可抑制小胶质细胞增殖及MMP-9的表达，从而可能延长UK治疗时间窗。

Minocycline can inhibit the proliferation of microglia and the expression of MMP-9 , and probably extends the therapeutic time window of UK .

米诺环素致IgA肾病及肺变应性血管炎

IgA nephropathy and pulmonary allergy vasculitis associated with minocycline

耐四环素的Uu和Mh株对多西环素、米诺环素、交沙霉素以及氧氟沙星存在交叉耐药性。

The tetracycline-resistant Uu or Mh showed cross resistance to doxycycline , minocycline , josamycin and ofloxacin .

米诺环素对衰老痴呆大鼠脑组织eNOS、iNOS表达的影响

Effect of minocycline on the expressions of eNOS and iNOS in brain of aged dementia rat

糖尿病大鼠海马内PAI-1的变化及米诺环素对其的影响

Change of plasminogen activator inhibitor type-1 in the hippocampus of diabetic rats and effect of minocycline

针对视网膜缺血再灌注损伤，米诺环素可升高SOD含量，降低MDA、NO含量，改善超微结构损伤而保护视网膜。

For retinal ischemia / reperfusion injury , minocycline can increase SOD content , degrade MDA and NO content , improve retina ultrastructure to protect the retina .

米诺环素对大鼠原代神经元和海马脑片缺氧缺糖及NMDA损伤的保护作用

Protective effect of minocycline on oxygen / glucose deprivation and NMDA-induced neurotoxicity in rat primary neurons and hippocampal slices

除米诺环素外，ESBLs基因阳性菌株对各种抗菌药物的耐药率均显著高于ESBLs基因阴性菌株（P0.01）。

ESBLs-positive isolates presented a dramatically higher resistance rate than negative ones for most antimicrobial agents except minocycline ( P0.01 ) .

目的探讨米诺环素（minocycline）对解脲支原体（UU）感染性精液不液化症的治疗效果。

Objective To elucidate the treatment of ureaplasma urealyticum ( UU ) infectious semen delayed liquefaction with minocycline .

米诺环素对2型糖尿病大鼠海马中PAI-1表达的影响

Minocycline 's Effects on the Expression of plasminogen activator inhibitor type-1 in the Hippocampus in a Type 2 Diabetes Model of Rats

方法通过对198例男性UU感染性精液不液化症分组进行治疗观察，探讨米诺环素治疗精液不液化症的疗效、UU转阴率和迟缓液化复发率。

Methods One hundred ninety eight cases of semen delayed liquefaction patients with UU infections were treated with minocycline and roxithromycin for 6 weeks .

米诺环素是对葡萄球菌最有效的四环素类抗生素，九十年代国产米诺环素问世，本研究表明国产米诺环素对MRSE、MSSE的效果均较好。

It showed antimicrobial activity of domestic minocycline was effective against MRSE .

注射用盐酸米诺环素在健康人体的药物动力学米诺环素对体外兔髓核细胞中NO、NOS表达的影响

Pharmacokinetics of minocycline hydrochloride in Chinese healthy volunteers Effect of Minocycline on the Expression of Nitric Oxide and Nitric Oxide Synthase in the Nucleus Pulposus Cells of Rabbits in Vitro

方法：把初始细菌指数（BI）≥4的多菌型麻风病70例在其完成MDT后分为治疗组和对照组，治疗组用ROM（利福平+氧氟沙星+米诺环素）方案继续治疗；

Methods : 70 patients with initial bacterial index ( BI )≥ 4 were allocated to ROM group and control group respectively by the end of MDT .

米诺环素对海马脑片OGD及NMDA损伤的作用：OGD损伤使海马脑片放射层透光度（LT）显著增加；MK一801（l抖mol/L）可显著抑制OGD引起的LT峰值增高（尸<0.05）；

Observation of the effect of minocycline on light transmittance change induced by OGD or NMDA in rat hippocampal slices .

方法神经元与不同浓度米诺环素和（或）N甲基D天冬氨酸（NMDA）作不同时间处理后，观察细胞形态，并以MTT试验评价细胞活性。

METHODS Cortical neurons were isolated from new born rats , primarily cultured for different days , treated by minocycline and / or N methyl D aspartate ( NMDA ) at different concentrations for different durations .

目的：观察米诺环素对阿糖胞苷（Ara-c）诱导的小鼠触须毛囊损伤的保护作用。

Objective : To investigate the protective effects of minocycline against hair follicle damage induced by cytosine arabinoside ( Ara-c ) .

一组（14例）用米诺环素，200mg（100mg／粒），po，qd×5d。

One group ( 14 patients ) was treated with minocycline hydrochloride 200 mg ( 100 mg / tablet ), po [ WTBZ ] , qd × 5 d.

米诺环素显著减轻SAH后EBI，减轻神经元凋亡，其保护机制可能与米诺环素抑制MMP-9表达，阻断细胞外凋亡通路有关。

Minocycline can relieve the EBI after SAH , and attenuate the neuronal apoptosis which may be related to the inhibition of MMP-9 expression and block the extracellular apoptotic pathway .

结果：治疗组肿瘤的生长明显受到抑制，米诺环素组肿瘤组织中的MMP9和MVD与对照组比较显著降低，抑瘤率为53.73%，血清碱性磷酸酶下降。

Compared with the control group , the tumor tissue MMP-9 and MVD of the Minocycline group were significantly reduced with an inhibition rate of 53.73 % and the serum alkaline phosphate decreased .

结果：得到了样品总离子流以及选择离子流相应色谱峰的ESI-MS质谱图，初步鉴定出盐酸米诺环素的主要相关物质A，B，C，D。

Ion power temperature : 150 ℃ . Results : The total ion current and each chromatographic peak of selected ion current were obtained , and resolution of these mass spectra was elucidated . The related substances A , B , C and D in minocycline hydrochloride were identified .

目的：观察成人慢性牙周炎应用盐酸米诺环素缓释软膏治疗前后龈沟液中碱性磷酸酶（Alkalinephosphatase，ALP）水平的变化。

Objective : To observe the change of alkaline phosphatase ( ALP ) in gingival crevicular fliud ( GCF ) in chronic adult periodontitis after treated the minocycline-HCL sustained release unguent as local drug delivery in the periodontal pocket as the auxiliary treatment of periodontitis .

EJ细胞体外培养后，加入不同浓度的四环素和米诺环素培养24h后再加入外源性的型胶原和层粘连蛋白，继续培养24h，用放射免疫法测定培养液中的型胶原和层粘连蛋白含量。

After EJ cells were incubated , treated with various concentrations of tetracycline and minocycline respectively for 24h , exogenous collagen and laminin were added into medium for another 24h in which laminin and ⅳ type collagen were assayed by radioimmunoassay .

目的研究米诺环素对体外培养的人牙周韧带细胞（HPDLCs）增殖及生物合成的影响。

Objective To evaluate the influence of minocycline on the proliferation and biosynthesis of human periodontal ligament cells ( HPDLCs ) in vitro .

结论：开封地区非淋菌性患者支原体感染以Uu为主，在9种常用治疗支原体的抗菌药物中以多西环素、米诺环素和克拉霉素耐药性较低，罗红霉素的耐药性最高。

CONCLUSIONS : The patients with non-gonococcus urethritis were chiefly caused by Uu infection in Kaifeng area . Of the 9 commonly used antibacterials against mycoplasma , doxycycline , minocycline and clarithromycin showed the lowest drug resistance , while roxithromycin showed the highest drug resistance .

米诺环素和四环素对EJ细胞增殖无明显影响，其原因可能是两者透过EJ细胞膜困难，不能影响细胞内线粒体内蛋白质合成。

Minocycline and tetracycline do not affect on growing of bladder tumor cells , probably due to EJ cell membranes had comparatively stronger barriers against both drugs to permeate , and without affecting mitochondria protein synthesis of EJ cells .

盐酸米诺环素糊剂治疗重度牙周炎的临床研究

A Clinical Study of Subgingival Minocycline Hydrochloride Ointment in Severe Periodontitis

盐酸米诺环素软膏治疗逆行性牙髓炎的临床评价

Clinical evaluation of minocycline ointment adjunctive treatment effect on retrograde pulpitis

盐酸米诺环素软膏在智齿冠周炎治疗中的作用

Application of Minocycline Hydrochloride Ointment in Treatment to Wisdom Tooth Pericoronitis