纳洛酮

纳洛酮对P物质中枢升压效应的易化作用

The Facilitating Effect of Naloxone on the Central Pressor Response of Substance P

纳洛酮在延髓腹外侧加压区加强P物质引起的升压效应

Pressor effect of substance P was strengthened by naloxone in the pressor area of ventral surface of medulla in rabbits

早期大剂量纳洛酮联合高压氧对CO中毒迟发性脑病的防治

Prevention and Treatment of Naloxone and Hyperbaric Oxygen on Delayed Encephalopathy after Carbon Monoxide Poisoning

方法腹腔注射递增剂量的盐酸吗啡使雄性SD大鼠形成吗啡依赖，并用纳洛酮催促戒断。

Methods Nucleus accumbens was dissected out from morphine dependent and naloxone precipitated withdrawal rats .

目的建立HPLC法用于盐酸纳洛酮鼻腔喷雾剂的含量及有关物质测定。

Aim To establish an HPLC method for the determination of naloxone hydrochloride nasal sprays and its related substances .

盐酸普萘洛尔脂质体鼻腔喷雾剂的研究HPLC法测定盐酸纳洛酮鼻腔喷雾剂的含量及有关物质

Studies on Nasal Nebula of Propranolol Hydrochloride-Containing Liposome Determination of Naloxone Hydrochloride Nasal Sprays and Its Related Substances by HPLC

结论微量（4g）纳洛酮可有效地减轻术后疼痛。

Conclusion Microdose naloxone administered intravenously can effectively relieve postoperative pain .

结论：硫酸镁联合纳洛酮治疗HIE有明显疗效。

Conclusion : Magnesium sulfate and naloxone have obvious effects in treating HIE .

纳洛酮在ICU中的应用

Clinical Use of Naloxone in ICU

结论：院前早期应用大剂量纳洛酮治疗急性CO中毒疗效显著，安全性高。

Conclusion : The large dose naloxone used in this manner is better than normal dose in safety and curative effect for saving acute CO poisoning .

纳洛酮对急性脑梗死患者血浆一氧化氮（NO）和内皮素（ET）的影响及疗效观察

Effects of naloxone on the endothelin and nitrogen monoxidum of blood plasma and clinical curative effect observation in patients with acute cerebral infarction

阿片受体阻滞剂纳洛酮能够改善这种损害，其神经机制并非是增加ChAT活性，而是能促进神经元突触囊泡Ach向突触间隙大量释放，及增加突触后致密物质密度。

The neuromechanism may not enhance ChAT expression quality , but augmentation Ach exocytosis and post-synaptic density .

方法反复sc吗啡建立小鼠吗啡身体依赖模型，以ip纳洛酮诱发其戒断症状。

Methods The physical dependence model was induced by repeated sc morphine daily in mice and then withdrawal symptom was induced by ip naloxone .

放线菌酮和纳洛酮影响甾体避孕药对大鼠垂体的GnRH激发效应

Cycloheximide and Naloxone Affect the GnRH-Pituitary Priming Effect induced by Steroidal Contraceptives in Rat

纳洛酮对发热大鼠下丘脑中cAMP和腹中膈区AVP含量的影响

Effects of naloxone on the contents of camp in hypothalamus and AVP in ventral septal area in fever rats

吗啡的作用可被纳洛酮所翻转。本实验提示，内源性鸦片样物质参预CRH分泌的调节。

( 3 ) The effect of morphine could be reversed by naloxone .

目的观察纳洛酮对严重颅脑损伤后神经细胞Caspase-3表达的影响，探讨Caspase-3介导的信号传递机制。

Objective To explore caspase-3 mediated signal transfer mechanism of the anti-apoptosis of naloxone to experimental severe traumatic brain tissue .

纳洛酮对脑缺血大鼠皮层SEP和Ca~（2+）-ATP酶活性的影响

Effect of naloxone on SEP and Ca ~ ( 2 + ) - ATPase activity in cerebral ischemia rats

方法：皮下注射（sc）盐酸吗啡建立吗啡依赖小鼠实验模型，在纳洛酮催促戒断前30min侧脑室微量注射甲氧氯普胺，观察其急性给药对吗啡依赖性戒断症状的影响；

Methods : Mice were administered ( sc ) with morphine hydrochloride to establish morphine dependence model .

故用于创伤性休克的治疗，TRH比纳洛酮更合适。

So TRH would be a better choice than naloxone in the treatment of traumatic shock .

采用侧脑室微量注射纳洛酮、乙酰胆碱的方法，观察了这两种物质对大鼠丘脑后核（PO）中痛敏神经元电活动的影响以及注药后尾核对这些神经元抑制作用的变化。

Intraventricular microinjection of naloxone and ACh showed effects on electrical discharging of neurons in posterior nucleus of thalamus ( PO ) in rats .

若在icvSP之前，预先向第四脑室注射阿片肽受体拮抗剂纳洛酮（100～200μg），可增强SP引起的肺动脉和颈动脉升压反应。

Pretreatment of opioid receptor antagonist naloxone ( 100 ￣ 200 μ g ) by intracerebroventricular ( 4th ) injection could enhance the SP induced pulmonary and carotid pressor responses .

SIN100mg·kg-1降低纳洛酮催促后1h内大鼠的戒断症状分值及抑制体重下降；

SIN ( 100 mg · kg - 1 ) inhibited the naloxone-precipitated withdrawal syndromes and body weight loss in morphine-dependent rats ;

目的研究在术后吗啡静脉自控镇痛（PCA）中加用小剂量纳洛酮对镇痛效果、吗啡用药量及其副作用的影响。

Objective To compare the analgesic effect and side effects of morphine for intravenous patient-controlled analgesia ( PCA ) with or without low-dose naloxone after abdominal surgery .

腹腔注射纳洛酮可增加脊髓背角的放电及刺激坐骨神经和LC时的放电频率。

The unit discharge rate of spinal dorsal has been increased by the intraperitoneal injection of naloxone , or by stimulation the sciatic nerve and the LC .

纳洛酮并不能完全拮抗舒芬太尼预处理对GIRI的保护效应，两组各参数比较仍有显著差别（P值均0.01）。

Naloxone does not completely antagonized the effect of sufentanil pretreatment on the GIRI , two groups of parameters there were still a significant difference ( P0.01 ) .

方法结合临床和影像资料，动态分析纳洛酮治疗脑梗死前后的SEP表现。

Methods With a comprehensive study of clinical imaging data , we analysed dynamically the brain infarction SEP before after naloxone treatment .

方法：对40例海洛因中毒者均采用静脉注射纳洛酮04mg～2mg。

Method : 40 cases of heroin poisoning were intravenously given 0.4mg ~ 2mg of Naloxone .

创伤性休克大鼠中性粒细胞CD18、糖皮质激素受体的变化及纳洛酮治疗作用的研究

Studies on expression of neutrophil CD18 、 glucocorticoid receptor and therapeutic effects of naloxone in traumatic shock of rats

目的观察纳洛酮对血管性痴呆（VD）大鼠海马锥体神经细胞核酸代谢的影响，探讨纳洛酮治疗对VD的神经生物学机制。

Objective To observe the effects of naloxone on DNA , RNA metabolism of hippocampal pyramidal neurons in rats with vascular dementia ( VD ) .