舒巴坦

目的：研究阿莫西林（AMC）/舒巴坦（SBT）不同配比（2：1和4：1）对临床分离致病菌的体外抗菌活性。

Objective : To evaluate the antibacterial activities in vitro of amoxicillin / sulbactam ( 2:1 and 4:1 ) .

方法：选择4℃、25℃、37℃，在3h内观察配伍液外观、pH值变化，并用RP-HPLC法测定阿莫西林与舒巴坦的含量。

Method The external appearance and PH values of the mixed solution were observed , and the contents of Amoxicillin and Sulbactam were determined by RP-HPLC method at 4 ℃、 25 ℃、 37 ℃ for 3 hours .

对氨苄西林-舒巴坦也有一定的耐药，TEM基因阳性志贺菌、TEM基因阴性志贺菌的耐药率分别为41.2%、20.6%。

About 41.2 % of TEM-gene positive S.flexneri and 20.6 % of TEM-gene negative S.flexneri were resistant to ampicillin-sulbactam .

结论10mg／0.1mL的头孢哌酮／舒巴坦玻璃体腔注射是一个安全剂量。

Conclusion 10 mg of Celoperazone / Sulbaclam is a safe dosage for rabbit intravitreal injection .

舒巴坦可以使头孢他啶对大肠杆菌、阴沟肠杆菌、弗劳地枸橼酸杆菌、不动杆菌属、铜绿假单胞菌的MIC90降低4倍；

Cloacae , C. freundii , Acinetobacter spp. , P.aeruginosa 4 folds and reduced the MIC90 of cefotaxime against E.

目的：测定头孢哌酮和哌拉西林与克拉维酸、舒巴坦、三唑巴坦3种β内酰胺酶抑制剂的复合制剂的最小抑菌浓度（MIC）、杀菌曲线。

Objective : To measure the minimal inhibitory concentration ( MIC ), time-kill curve of the composite preparation of β - lactams and β - lactamase inhibitors against β - lactamase-producing Gram-negative bacteria in vitro .

氨苄西林与舒巴坦以2∶1、4∶1配比联用时，其对分离产酶菌的MIC值分别降低10~40倍、10~20倍。

MICs of ampicillin against lactamase-producing isolates decreased by 10-40 and 10-20 times , respectively , when it was conbined with sulbactam at ratio of 1 2 and 1 4 . All clinical isolates were susceptible to third-generation cephalosporins .

产ESBLs株对亚胺培南均呈敏感，对头孢西丁、头孢哌酮-舒巴坦及哌拉西林-三唑巴坦耐药率较低，对其他抗菌药物的耐药率均较不产ESBLs株高。

All ESBLs producing strains in our study were susceptible to imipenem , and relatively susceptible to cefoxitin , cefoperazone-sulbactam and piperacillin-tazobactam . ESBLs-producers had much higher resistance rates to other antimicrobial agents compared with ESBLs non-producing strains .

目的研究头孢哌酮（CPZ）及不同配比头孢哌酮/舒巴坦（CPZ/SBT）对临床分离致病菌的体外抗菌活性，为临床提供用药依据。

Objective To study the antibacterial activity in vitro of cefoperazone ( CPZ ) and different ratio of cefoperazone / sulbactam ( CPZ / SBT ) and to supply the clinical doctors with useful information .

本文进行了8名健康男性志愿者交叉口服两种舒他西林片剂的生物等效性试验，给药剂量为750mg，建立了HPLC法测定血清中氨苄西林（AMP）、舒巴坦（SBT）的药物浓度。

Healthy male volunteers were enrolled in a two period cross-over bioequivalent study of sultamicillin tablet , HPLC method was established and used to assay the concentration of the active metabolites of sultamicillin-ampicillin and sulbactam in human serum after oral administration of 750 mg sultamicillin tablets .

比较头孢哌酮/舒巴坦（CPZ/SB）、亚胺培南/西司他丁（IPM/CS）与头孢他啶（CAZ）治疗老年人肺部感染的疗效及其安全性。

To evaluate the efficacy and safety of cefperazone / sulbactam ( CPZ / SB ) , imipenem / cilastatin ( IPM / CS ) versus ceftazidime ( CAZ ) in the treatment of lower respiratory tract infections in the elderly .

舒巴坦/头孢哌酮与头孢噻肟随机对照多中心临床研究

Multicenter randomized controlled clinical trial on sulbactam / cefoperazone versus cefotaxime

头孢哌酮-舒巴坦（商品名舒普深）与头孢曲松治疗新生儿肺炎对照分析

Comparing sulbactam - cefoperazone and cefotaxime in treatment pneumonia of infant

舒巴坦/头孢哌酮治疗老年人下呼吸道感染疗效的临床评价

Treatment of lower respiratory infections with sulbactam / cefoperazone of elderly

舒巴坦与β-内酰胺抗生素联用的体外抗菌活性研究

In vitro antibacterial activities of sulbactam plus β - lactam antibiotics

头孢哌酮/舒巴坦在开胸术后感染治疗中的评价

Evaluation of Cefoperazone / Sulbactam in the Treatment of Chest Postoperative Infection

舒巴坦与米诺环素对多药耐药鲍氏不动杆菌体外联合药敏研究

In-vitro Activity of Sulbactam in Combination with Minocycline Against Multidrug-resistant Acinetobacter baumannii

舒巴坦的工艺优化研究

Research of the Optimizing Process of Sulbactam

舒巴坦匹酯原料残留溶剂的评价

Evaluation of Residual Solvent in Sulbactam Pivoxil

氨苄西林／舒巴坦的临床评价

Clinical evaluation of ampicillin / sulbactam

结论头孢哌酮/舒巴坦是一种抗菌谱广、疗效显著、副作用少的抗菌药物，特别适用于重症下呼吸道医院感染的疾病治疗。

CONCLUSIONS Sulperazone is effective and safe in the treatment of severe nosocomial lower respiratory infection .

头孢哌酮／舒巴坦体内外抗菌活性及其与细菌β－内酰胺酶的关系

In vitro and in vivo antibacterial activities of cefoperazone / sulbactam and their relationships with β lactamase

方法：用平皿二倍稀释法测定了舒巴坦与头孢他啶、头孢噻肟、头孢呋辛1：1联合的体外抗菌作用。

METHODS : The in vitro combination antibacterial activities were studied by using two-fold plate dilution methods .

乳酸左氧氟沙星与头孢哌酮/舒巴坦对照治疗老年人呼吸道感染的临床研究

Clinical evaluation of levofloxacin lactate and cefoperazone / sulbactam in the treatment of respiratory tract infections in elderly patients

目的研究（1∶1）头孢哌酮（第3代头孢类抗生素）/舒巴坦（β内酰胺酶抑制剂）在成年与老年的药代动力学。

Objective To study the pharmacokinetics of cefoperazone and sulbactam ( 1 ∶ 1 ) in healthy adult and old people .

方法：应用计算机辅助褶合曲线分析法，结合计算机信息处理技术，同时测定头孢哌酮和舒巴坦的含量。

Methods : The computer aided convolution curve method has been applied to determine the content of cefoperazone and sulbactam simultaneously .

目的研究比较静脉滴注哌拉西林/舒巴坦（4∶1）复方制剂在健康志愿者中的药动学。

Objective To study the pharmacokinetics of a single dose of piperacillin / sulbactam ( 4 ∶ 1 ) injection in healthy volunteers .

对β-内酰胺类抗生素复合剂哌拉西林胞唑巴坦（P/T）、氨苄西林/舒巴坦（A/S）敏感率分别为75.8%和3.5%；

The sensitive rate of - lactam comparator P / T , A / S was 75.8 % , 3.5 % , respectively .

结论：哌拉西林／舒巴坦（1：1、2：1、4：1）是一个有效的β－内酰胺酶抑制剂联合制剂，三种配比的哌拉西林／舒巴坦体外抗菌活性相似，有进一步研究开发价值。

CONCLUSION : Piperacillin / sulbactam ( 1:1,2:1 , 4:1 ) is a effective antibiotic containing β - lactamases inhibitor and valuable to be investigated .

将米诺环素和头孢哌酮/舒巴坦（1：1）的药物浓度依次倍比稀释，设置11个稀释浓度。

The effects of minocycline and cefoperazone / sulbactam ( 1:1 ) drug concentrations in turn times than dilution , set a dilution 11 concentration .