西司他丁

方法哌拉西林钠/他唑巴坦钠3.375g静脉滴注，每12h一次，或亚胺培南/西司他丁0.5g静脉滴注，每12h一次，治疗中、重度肺部感染，疗程为7-14d。

Methods Pipercillin / tazobactam 3.375g iv or imipenem / cilastatin 0.5g iv treated moderate and severe pulmonary infection every 12h for 7 14 days .

65例亚胺培南/西司他丁药品不良反应分析

Adverse Reactions due to Imipenem / cilastatin : A 65 Case Analysis

西司他丁钠及其E构型异构体的合成

Synthesis of Cilastatin Sodium and Its E-isomer

西司他丁钠的E构型异构体经HPLC、LC-MS、NOSEY谱等确证其结构。

The structure of the E-isomer of Cilastatin sodium was confirmed by HPLC , LC-MS and NOSEY etc.

西司他丁钠经HPLC、~1H-NMR、~（13）C-NMR、DEPT和MS等确证其结构。

The structure of Cilastatin sodium was confirmed by HPLC , ~ 1H-NMR , ~ ( 13 ) C-NMR , DEPT and MS etc.

方法对全军药品不良反应（ADR）监测中心数据库中亚胺培南/西司他丁的药品不良反应病例进行数据分析，重点分析发生不良反应的患者年龄、临床表现、用药合理性等。

METHODS The data of imipenem / cilastatin ′ s adverse reaction from the data base of the PLA Center for ADRs Monitoring were used to analyze the age of ADR sufferers , their ADR representation , the rationality of clinic use of medicine etc.

比较头孢哌酮/舒巴坦（CPZ/SB）、亚胺培南/西司他丁（IPM/CS）与头孢他啶（CAZ）治疗老年人肺部感染的疗效及其安全性。

To evaluate the efficacy and safety of cefperazone / sulbactam ( CPZ / SB ) , imipenem / cilastatin ( IPM / CS ) versus ceftazidime ( CAZ ) in the treatment of lower respiratory tract infections in the elderly .

亚胺培南/西司他丁的抗生素后效应及其影响因素的研究

Postantibiotic effect of imipenem / cilastatin and its influence factors

美罗培南和亚胺培南-西司他丁对100株革兰阴性杆菌体外抗菌活性比较

Comparative in vitro antimicrobial activity of meropenem and imipenem-cilastatin against 100 gram-negative bacilli

亚胺培南/西司他丁对肺炎大鼠的免疫调节作用

Immunomodulating effects of imipenem / cilastatin in pneumonic rats

伊米配能/西司他丁与其它3种抗生素的体外抗菌活性比较

Comparison of in vitro antibacterial activity of imipenem / cilastatin and three other antibiotics

亚胺培南/西司他丁治疗肾移植后重症肺部感染的临床分析

A Clinical Analysis of the Therapeutic Effect of Imipenem on Severe Pneumonia Following the Kidney Transplantation

观察组予以抗生素降阶梯治疗，使用亚胺培南-西司他丁钠；

The observation group to antibiotic treatment , use ladder down imipenem-west company he d sodium ;

亚胺培南/西司他丁钠对重症感染的疗效观察

Sodium citrate ; Imipenem / cilastatin Used for Severe Bacterial Infection Patients in Emergency Intensive Care Unit

亚胺培南/西司他丁与头孢他啶治疗中、重度细菌感染疗效费用分析比较研究

Cost effectiveness analysis of imipenem / cilastatin versus ceftazidime in the treatment of moderate and severe bacterial infection

小剂量亚胺培南/西司他丁在肺部感染患者中的药动学及疗效观察

A study on pharmacokinetics and therapeutic efficacy of small dosage of imipenem / cilastatin in patients with pulmonary infection

方法采用随机对照试验，亚胺培南/西司他丁作对照药。

Methods A randomized controlled clinical trial was performed and imipenem / cilastain was employed as the control drug .

加用亚胺培南/西司他丁预防方案对造血干细胞移植后早期感染的影响

Prophylaxis effect on early infectious complications following hematopoietic stem cells transplantation with antibiotic regimen augmented by imipenem / cilastatin

目的进一步了解近年来亚胺培南/西司他丁的用药安全性，为临床合理使用亚胺培南/西司他丁提供依据。

OBJECTIVE To comprehend the security of imipenem / cilastatin more and supply the gist of reasonable use for clinic .

总有效患者为232例（80.7%）。结论应用亚胺培南/西司他丁治疗血液肿瘤合并感染的患者，具有疗效快、作用显著之特点。

CONCLUSIONS Tienam has characteristics of rapid and obvious efficacy in treating patients suffered from blood tumor combined with the infection .

结果：用亚胺培南-西司他丁钠盐的患者感染迅速被控制，疗效显著。

RESULTS : Infections in the patients given imipenem cilastatin sodium were rapidly controlled and the effects of which were definite .

西司他丁是一种肾脱氢二肽酶抑制剂，其与亚胺培南复配的抗菌药物&泰能在临床上应用广泛。

Cilastatin is an important inhibitor of dehydropeptidase-I , which can enhance the antibacterial activity of Imipenem and has widely clinic applications .

目的：评价亚胺培南/西司他丁治疗老年人肺部感染的临床疗效及安全性。

AIM : To study the efficacy and tolerance of intravenously administered imipenem / cilastatin in the treatment of elderly pulmonary infection .

有18次培养出耐亚胺培南/西司他丁的细菌，革兰阳性细菌占72.2%；

69.2 % Patients were detected out the bacteria resistance to imipenem / cilastatin , Gram positive pathogens accounted for 72.2 % .

目的评价美罗培南与亚胺培南-西司他丁钠治疗老年重度医院获得性肺炎的有效性和安全性。

AIM To evaluate the efficacy and safety of meropenem and imipenem in the treatment of elderly patients with severe hospital-acquired pneumonia .

烧伤患者应用亚胺培南/西司他丁钠盐或头孢哌酮后部分炎症介质水平的改变

Changes in plasma levels of LPS , TNF - α and IL-6 in burn patients with severe infection treated with Imipenem or Cefoperazone

目的观察亚胺培南/西司他丁对血液系统疾病并发院内感染的治疗效果。

Objective To evaluate the clinical efficacy of imipenem / cilastatin in the treatment of nosocomial infectious complications in patients with hematological diseases .

结论移植前在常规抗生素预防方案基础上加用亚胺培南/西司他丁可以推迟移植早期感染的发生时间，对移植早期感染的预防有一定的效果。

Conclusion Imipenem / cilastatin prophylaxis regimen can postpone the early infection incidence and may has effect on the early infectious complications prevention .

目的以亚胺培南/西司他丁作为对照药物，评价哌拉西林钠/他唑巴坦钠治疗中、重度肺部感染的有效性和安全性。

Objective Randomized compared with imipenem / cilastatin to evaluate the efficacy and safety of Pipercillin / tazobactam in the treatment of pulmonary infection .

结论国产美罗培南治疗医院获得性下呼吸道感染是有效和安全的，与亚胺培南/西司他丁相比无显著性差异。

Conclusion Domestic meropenem is an effective and safe antibiotic for the treatment of hospital acquired lower respiratory infection as well as imipenem / cilastatin .