钠通道

自发性癫痫大鼠钠通道β1亚基DNA表达分析

The Expression of Sodium Channel β _1 Subunit DNA in Spontaneously Epileptic Rat

自发性癫痫大鼠脑内电压门控性钠通道α亚基mRNA的改变

Change of Voltage-gated Sodium Channel α Subunit mRNA in Brain of Spontaneously Epileptic Rat

急性分离的肺泡Ⅱ型上皮细胞钠通道亚基mRNA表达

Epithelial sodium channel subunit mRNA expression in acutely isolated rat alveolar type ⅱ cells

结论SER脑内海马Ⅲ型电压门控钠通道N亚型表达上调。

Conclusion The expression of type ⅲ sodium channel ⅲ N is up regulated in hippocampus of SER brain .

电压敏感的钠通道是DDT和拟除虫菊酯类杀虫剂的主要靶标。

The voltage-sensitive sodium channels are important action targets of DDT and pyrethroids .

目的探讨急性胰腺炎后心肌细胞快钠通道电流（I（Na））的变化。

Objective To study the changes of sodium currents ( I_ ( Na )) of ventricular cells in rats after acute pancreatitis .

兔冠状动脉结扎1h缺血区心肌细胞快钠通道电流的变化

Changes of sodium channel of myocytes in ischemic zone of rabbits 1 hour after coronary artery occlusion

结果①CGRP可以使大鼠海马神经细胞钠通道电流的峰值增加41%；

Results ① CGRP could enhance 41 % the Na ~ + channel currents of hippocampal neurons ;

海葵毒素对心肌钠通道开放模式、动作电位及心电图QT间期的影响

Effect of ATX ⅱ on opening modes of myocyte sodium channel , action potential and QT intervals of ECG

淡色库蚊（Culexpipienspallens）与击倒抗性（kdr）相关的钠通道基因突变

Linkage of knockdown resistance and the sodium channel gene mutation in Culex pipiens pallens

野木瓜注射液对大鼠DRG细胞钠通道影响的实验与计算机仿真研究

The Experiment and Computer Simulation Research of Effect of Injection Stauntoniae on Rat Dorsal Root Ganglion Neuron

两种蚊虫钠通道基因kdr突变点附近序列的研究

DNA Sequence Analysis of Two Mosquitoes Sodium Channel Genes Adjacent to the kdr Mutation Point

结论：SER钠通道β1亚基2-5外显子表达与正常大鼠无差别。

Conclusions : The β 1 subunit 2-5 exons expression of SER has no significant difference between control rats .

结果当ATXⅡ特异性地与钠通道结合后，早钠通道电流增大。

Results The early sodium channel current was specifically increased by ATX ⅱ .

方法：全细胞膜片钳技术记录急性分离SD大鼠（7～10d）颈上交感神经节细胞钠通道电流；

METHODS : Whole cell patch clamp recordings were made from enzymatically isolated rat ( 7 - 10 d ) superior cervical sympathetic ganglion neurons .

结果：SER钠通道β1亚基2-5外显子碱基序列与原序列的同源性为100%。

Results : SER sodium channel β 1 subunit 2-5 exons sequence have 100 % homology with the sequence of the original sequence .

东亚钳蝎毒素多肽纯化组份BmKAS-1对大鼠背根神经节神经元河豚毒素不敏感型钠通道电流的作用

Effects of BmK AS-1 on TTX-R Sodium Channel Currents in Rat DRG Neurons

目的研究4氨基吡啶（4AP）对心肌细胞L型钙通道和钠通道的影响。

AIM To investigate the effect of 4-aminopyridine ( 4-AP ) on ion channels of myocytes .

结果SER海马Ⅰ型与Ⅲ型钠通道α亚基mRNA表达高于WTC（P<0·01）；

Results Type ⅰ and ⅲ sodium channel α subunits mRNA of SER expressed significantly higher than those of WTC in hippocampus ( P < 0.01 ) .

结果：血竭剂量依赖地抑制单个DRG细胞电压门控性钠通道电流，高剂量的血竭抑制作用不可逆。

Results : blood resin suppressed amplitude of the sodium channel currents in a dose dependent way . The inhibition effect was irreversible at high dosage .

目的观察大鼠背根神经节（DRG）电压门控钠通道αⅢ在不同疼痛模型中的变化，探讨慢性神经痛的发生机制。

Objective To investigate the changes of αⅲ sodium channel transcript in dorsal root ganglion ( DRG ) neurons in different models of chronic neuropathic pain .

目的探讨自发高血压大鼠（SHR）肥厚心肌钠通道电流的动态演变规律及与左心室肥厚的关系。

Objective To study the change in sodium channel current (ⅰ Na ) in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat ( SHR ) .

结论在DNP作用下，利多卡因可通过抑制电压依赖性钠通道起到脑保护作用。

Conclusion With the use of DNP , lidocaine can achieve the effect of brain protection through inhibiting the voltage-dependent sodium channel .

目的：对照研究自发性癫痫大鼠（SER）和正常大鼠钠通道β1亚基外显子表达情况。

Objective : To investigate exons expression of voltage-gated sodium channel β 1 subunit in spontaneously epileptic rat ( SER ) and Wistar rat by control study .

由此提示GA与失活态的钠通道结合而抑制I（Na）对I（Na）的阻滞作用为其抗心律失常作用的主要机制。

These results suggested that GA inhibited I_ ( Na ) by binding to the inactivated state of sodium channel and bolcking effects of GA on I_ ( Na ) were the major mechanism of its antiarrhythmic action .

目的记录钠通道阻滞剂利多卡因对2,4-二硝基苯酚（DNP）作用下神经元电生理变化的影响。

Objective To explore the effect of lidocaine , the sodium channel blocker , on electrical physiological changes in the circumstances of hypoxia .

AN-132阻滞心肌钠通道的闸门相关受体分析

AN-132 block of cardiac sodium channels : a gate-related receptor analysis

并用TTX、CdCl2分别阻断电压依赖性钠通道和钙通道。

At the meantime , TTX and CdCl 2 were used to block voltage _dependent Na + Channel and Ca 2 + channel .

目的：观察电压门控钠通道NaN/SNS2在大鼠坐骨神经慢性压迫性损伤（Chronicconstrictioninjury，CCI）14天后的变化，探讨慢性神经痛的发生机制。

The present study was to investigate the changes of TTX R sodium currents and NaN / SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury ( CCI ) of sciatic nerve 14 days after surgery .

目的：探讨SO2及其体内衍生物（亚硫酸盐和亚硫酸氢盐）对中枢神经元钠通道的影响。

AIM : To study the effects of sodium meta bisulfite ( SMB ), sulfur dioxide ( SO_2 ) and its derivatives in vivo , sodium bisulfite and sulfite , on Na ~ + currents .