长春碱

建立了硫酸长春碱的HPLC分析方法。

At first , the HPLC method of analysis was established .

长春碱纳米粒对C6神经胶质瘤细胞生长和凋亡的影响

Effects of vinblastine nanoparticles on growth and apoptosis of glioma cell line C6

Caspase-3抑制剂抑制长春碱诱导的人乳腺癌细胞凋亡及IκΒ-α降解

Attenuation of vinblastine-induced apoptosis and degradation of I κ B - α in breast cancer cell line by caspase-3 inhibitor

长春碱是从夹竹桃科植物长春花（Catharanthusroseus）中分离得到的一种具有抗癌活性的生物碱。

Vinblastine is a kind of alkaloid extracted from Catharanthus roseus , which has anticancer bioactivity .

目的研究从长春碱（VLB）分子印迹聚合物中抽提模板分子的合适条件。

Objective To investigate the optimal condition for complete removal of the template molecules from vinblastine ( VLB ) - imprinted polymer .

本研究拟比较吉西他滨联合顺铂（GP）方案与吉西他滨联合去甲长春碱（GN）方案治疗晚期NSCLC的疗效、生存率及毒副反应。

The aim of this study was to assess efficacy , survival rate and toxicity of gemcitabine + cisplatin regimen ( GP ) versus gemcitabine + vinorelbine regimen ( GN ) in the treatment of advanced NSCLC patients .

本文建立了长春碱的RP-HPLC分析方法和样品制备方法，研究了从鲜长春花中高效提取、纯化长春碱的方法，确定了全新的生产工艺，并进行了中试放大实验。

In this paper we established RP-HPLC determination method and sample preparation method , and studied on the technology of vinblastine high effective extraction and purification , and finished the middle experiment from fresh catharanthus roseus . And finally we established the new vinblastine produce process .

从喜树（CamptothecaacuminataDecne）的根、枝条、叶和果实中分离纯化了48株内生真菌，其中菌株J-3、J-4J、-5、J-8对盐酸罂粟碱、硫酸长春碱等天然活性产物具有转化能力。

48 strains of endophytic fungi were isolated from the roots , branches , leaves and fruits of Camptotheca acuminata Decne , among which strains J-3 、 J-4 、 J5 、 J-8 could modify the structures of papaverine and vinblastine .

长春碱含量仅与枝下高显著负相关。

Vinblastine content only with below-branch height had significant negative correlation .

两种不同长春碱类药物治疗晚期非小细胞肺癌的近期疗效比较

Comparative Study of Two Different Drags of Vinca for Advanced Non-small-cell Lung Cancer

硫酸长春碱温敏性凝胶的释药特性和抗血管生成活性研究

Studies on Drug Release Characteristics and Anti-angiogenic Activity of Vinblastine Sulfate Thermosensitive Hydrogels

长春碱高效提取纯化的工艺研究

Study on High Effective Extraction and Purification Process of Vinblastine from Catharanthus Roseus

长春碱分子印迹聚合物中模板分子的抽提

Removal of the template molecules from vinblastine-imprinted polymer

长春碱纳米粒的细胞毒性和急性毒性研究颗粒细胞性成釉细胞瘤

Cytotoxicity and acute toxicity study on vinblastine ( VLB ) nanoparticles granular cell ameloblastoma

从硫酸长春碱合成抗癌药酒石酸长春瑞宾，总收率15.3%。

Antitumor drug vinorelbine tartrate was synthesised from vinblastine sulfate in 15.3 % overall yield .

失碳长春碱联合化疗治疗晚期乳腺癌

Navelbine combination chemotherapy for advanced breast cancer

钙通道阻滞剂对长春碱类抗癌药物的体内体外增效作用

Enhancement of cytotoxicity of vinca alkaloids in vitro and in vivo by calcium channel blockers

醛基长春碱的一种新来源

A new source of vincristine

适当的水肥胁迫有利于长春碱在长春花体内的形成和积累。

Suitable stress is advantageous to the formation and the accumulation of vinblastine in the Catharanthus roseus .

目的对使用长春碱类药物或化疗后产生粒缺并发肠道感染而导致中毒性肠麻痹的治疗进行探讨。

Objective To study the treatment for toxic enteroparalysis after using Vinblastinums or chemotherapy which leads to agranulocytosis combining with intestinal infection .

方法用失碳长春碱联合阿霉素或5－氟脲嘧啶或顺铂治疗晚期乳癌20例。

Methods Twenty patients with advanced breast cancer were treated with NVB plus Adriamycin or NVB plus 5-Fluorouracil or NVB plus Cisplatin combined chemotherapy .

迄今，许多抗肿瘤药物如紫杉烷类、长春碱类和蒽醌类等，在临床上都出现了多药耐药性。

To date , various anticancer drugs which are most frequently associated with MDR including taxanes , vinca alkaloids , anthracyclines and so on .

体外药敏试验显示化疗后肿瘤细胞对长春碱类及蒽环类的耐药比率明显增加（P<0.05）。

In vitro chemosensitivity test revealed that the ratio of resistance to vinca alkaloids and anthracyclines were increased after chemotherapy ( P < 0.05 ) .

有研究证明，长春碱不能利用细胞培养的方法在植物体外合成，所以，探索使用其他方法使其生物碱量上升对长春花药用功效有重要意义。

Studies have shown that vinblastine cannot be produced by cell culture in vitro synthesis in plants ; therefore , exploring methods of alkaloid rise in Catharanthus roseus has important significance .

综合分析，多种化疗药物均可引起周围神经病变，包括铂类、紫杉类、长春碱类、蛋白酶抑制剂、沙利度胺及类似物。

Analysis by synthesis , many different anticancer agents may cause chemotherapy induced peripheral neuropathy , such as platinum salts , taxanes , vinca alkaloids , bortezomib , thalidomide and analogs .

通过重铬酸与长春碱反应一步生成长春新碱，并通过层析分离得到99%长春新碱。

Synthesize Dichromic acid with VLB to obtain Vincristine ( VCR ) by one-step reaction , and the 99 % purity of Vincristine ( VCR ) was obtained by chromatography method * 4 .

根据对微管作用的不同将药物分为两类：抑制微管蛋白聚合的药物，如长春碱类；稳定微管的药物，如紫杉烷类和埃坡霉素类。

These agents can be divided into two major classes based on their effect on microtubule polymerization and the mass of microtubule polymers : those that inhibit polymerization , such as the vinca alkaloids and those that stabilize microtubules , such as the taxanes and epothilones .

HPLC法测定异长春花碱静脉注射乳剂中主药的含量

Content Determination of Main Component in Intravenous Emulsion of Vinorelbine by HPLC

B组用国产异长春花碱（盖诺）联合顺铂，男40例，女20例。

Sixty patients were treated with homemade vinorelbine plus cisplatin ( group B ), including 40 males and 20 females .

结果长春花碱抑制C6细胞葡萄糖摄取24%～36%。

Results Vinblastine inhibited basal glucose uptake by 24 % to 36 % .