抗独特型抗体

马立克氏病毒单克隆抗独特型抗体间接ELISA方法的建立

Establishment of Indirect ELISA Method of Anti-idiotypic Antibodies of MDV

黄曲霉毒素B1抗独特型抗体的制备和应用研究I抗独特型抗体的制备和性质研究

Preparation and application of aflatoxin b1 ( afb1 ) anti-idiotype antibody I. Study on Preparation and characterization of afb_1 anti-idiotype antibody

抗独特型抗体（Ab2）是指针对独特型抗体（Ab1）的独特型抗原决定基产生的抗体。

Antibody idiotype is the antigen determinant of antibody .

结论建立了MDV抗独特型抗体的间接ELISA方法。

Conclusions The indirect ELISA and competition - inhibition ELISA methods are established .

含4个抗原决定簇的DNA疫苗免疫的6只小鼠中有4只产生了特异性抗独特型抗体，但滴度均较低（最高滴度1∶80）；

Specific anti-idiotype antibody was detected in all of the six mice immunized with DNA vaccine containing all the five determinants ( the highest titer was 1 ∶ 480 ) .

具有疟原虫CSP内影像的单克隆抗独特型抗体的制备及鉴定

Production and Identification of Monoclonal Anti-idiotype Antibody That Bears the Internal Image of CS Protein of Plasmodium

鼻咽癌患者血清中Epstein-Barr病毒早期抗原特异性抗体的IgA类抗独特型抗体的检测

IgA class anti-idiotypic antibody against antibody to Epstein-Barr virus early antigen in sera from nasopharyngeal carcinoma patients

人源日本血吸虫Fab抗体库的构建及抗独特型抗体的筛选、鉴定

Screening and identification of a human Fab antibody against idiotypic antibody from a phage-display library of schistosoma japonicum

而抗独特型抗体（Ald）阳性单明显高于其它组，且针对抗-HBs独特型的LTT反应也十分活跃。

To the idiotype of anti - HBs showed very activity .

不同免疫程序对MDV抗独特型抗体苗效果的影响

Effect of Different Immune Processes on Efficiency of Anti-idiotypic Antibodies Against MDV

牛布氏杆菌抗独特型抗体F9小鼠免疫实验

Immune Test of Anti-idiotype Antibody F9 of Brucella Abortus to Mice

以鼠RBC为载体将其吸附于RBC上进行小鼠免疫试验，检测结果表明该抗独特型抗体具有良好的免疫原性，能诱导免疫动物产生相当效价的抗布氏杆菌抗体（Ab3）。

By mouse immunization test , it was proved that this anti-idiotype antibodies possessed good immunogenicity and induced inoculated animals to produce the high titer of antibodies against Brucella .

肿瘤的免疫治疗是生物治疗重要方法之一，目前，抗独特型抗体疫苗、抗原疫苗及DNA疫苗等都取得一定的进展，但仍然存在某些不足，没有达到预想的结果。

The immune therapy is one important method of biological therapies . Up to now , there was great progress in anti-idiotypic vaccine > antigen vaccine and DNA vaccine , but there are some defects in it , not reaching the expectant effect .

结果所研制的抗独特型抗体经过鉴定，是Ab2β型，与T-2毒素存在内影像关系。结论该抗体可以替代T-2毒素标准品应用于ELISA检测。

Conclusion The obtained polyclonal anti-idiotype antibody was the " inner image " with T-2 toxin and can be used to replace T-2 toxin standard in ELISA .

我室制备了人绒毛膜促性腺激素（hCG）的抗独特型抗体，它们与hCG有相似的抗体和受体结合位点，因而认为它们可能具有hCG内镜像结构。

HCG anti-idiotype antibodies ( hCG Anti-Ids ) have been prepared in our laboratory . It has been demonstrated that these hCG Anti-Ids have similar domains with hCG and can bind to hCG receptor .

日本血吸虫抗独特型抗体NP30抗体检测法在云南大山区应用效果的评价

Potency of anti-idiotypic antibody NP30 / antibody detection for schistosomiasis japonica in mountainous areas in Yunnan Province

以往研究表明，日本血吸虫抗独特型抗体NP30是一个极有潜力的血吸虫病疫苗候选分子。

Previous studies have demonstrated that anti-idiotypic antibody NP30 may represent a promising vaccine candidate for schistosomiasis japonica .

目的探讨MDV（Marek'sDiseaseVirus马立克氏病毒）抗独特型抗体（Ab2）模拟抗原诱导机体产生抗MDV感染的能力。

Objective To study the protective efficacy of anti-idiotypic antibody ( Ab2 ) that simulates the antigen to induce the immunity against the infection of Marek 's disease virus ( MDV ) in chicken .

目的研究日本血吸虫单克隆抗独特型抗体NP30对虫卵肉芽肿的影响。

Objective To study the immunoregulative effect of the monoclonal anti-idiotypic antibody NP30 of Schistosoma japonicum on egg granulomas .

免疫网络学说认为抗体分子除具有与抗原结合的特性外，还具有自身免疫原性的独特型（idiotype，Id），可激活淋巴细胞产生抗独特型抗体（anti-idiotypicantibody，AId）。

In immunology network people think antibody molecule have both the character of react with antigen and the character of immunogenicity ( idiotype , Id ) which can activate the lymphocyte to produce anti-idiotypic antibody , AId .

分泌带有PGL-I末端三糖内影像的单克隆抗独特型抗体杂交瘤的建立

Development of Secreting Monoclonal Anti-idiotypic Antibodies That Bear the Internal Image of the Terminal Trisaccharide of PGL-I

以上研究证明日本血吸虫单克隆抗独特型抗体NP30具有较好的抗感染免疫和抗病免疫功效，可作为日本血吸虫病疫苗候选分子。

Anti-idiotypic antibody NP30 was confirmed with protective immunity of both anti-infection and anti-pathology and may act as a vaccine candidate for schistosomiasis japonica .

1.75%聚乙二醇（MW6000）沉淀血清免疫复合物后，采用ELISA法检测上清中抗独特型抗体〔抗-（抗-HBs）〕。

Anti-idiotypes directed against anti-HBs in the supernatant were detected by enzyme-linked immunosorbent assay ( ELISA ) after precipitation of immune complexes from sera with polyethylene glycol 6000 ( PEG ) .

目的探讨卵巢癌抗独特型抗体6B11表位多肽与诱导免疫应答之间的关系。

Objective To explore the relationship between the immune response induced by6B11 anti-idiotypic antibody and its epitope peptides .

目的观察重组IL-2、IL-6和TNF-α（rIL-2，rIL-6，rTNF-α）作为血吸虫病抗独特型抗体疫苗佐剂的可行性，并探讨其作用机制。

Objective To observe whether recombinant IL-2 , IL-6 and TNF - α ( rIL-2 , rIL-6 , rTNF - α) can be served as adjuvants of anti-idiotypic antibody vaccine for schistosomiasis and analyze their mechanisms of protective immunity .

作者应用正交设计观察了单克隆抗独特型抗体NP30主动免疫诱导的保护性免疫力。

In this paper , by using the orthogonal design method the protective immunity induced by active immunization with anti-idiotypic monoclonal antibody NP30 was investigated from a challenge infection .

主要步骤为：用以低亲合力结合SpA的小鼠免疫球蛋白如IgG1包被，加入待检抗独特型抗体，最后以HRP-SpA显示其反应。

The main procedures were as follows : coating by mouse IgG subclass with low affinity to SpA such as IgG1 or IgM , adding anti-idiotype , then HRP-SpA was used to display the binding between idiotype and anti-idiotype .

本研究不仅表明了针对PHSA的免疫应答中独特型网络调节的客观存在，而且在其抗独特型抗体（anti-Id）中，的确存在具有PHSA内映像的成分。

These data indicate that the idiotype ( Id ) network modulate the immune response to PHSA and that the anti-Id specific for anti-PHSA have the internal image composition .

结论：成功构建了人源日本血吸虫Fab抗体库，并从中获得人源日本血吸虫抗独特型抗体B6，为研制用于人体血吸虫病免疫预防的抗独特型抗体疫苗奠定了基础。

Sequencing was also carried out . Conclusion : A schistosoma japonicum human Fab phage-display library could be successfully constructed , from which anti-idiotypic antibody ( B6 ) of schistosoma japonicum is obtained . And it is useful for further study on anti-idiotypic antibody vaccine development of schistosoma japonicum .

由于部分日本血吸虫的保护抗原为糖类或糖复合物，难以用基因工程技术制备，因此，抗独特型抗体（anti-id）疫苗的研究受到日益重视。

As the use of sugar materials or molecules containing sugar ( proteoglycans , glycoproteins and glycolipides ) are the protective antigens of schistosoma , it is difficult to produce vaccines by the technique of genetic engineering . Anti-idiotypic antibody vaccines of schistosomiasis have aroused great attention .