血管生成抑制因子

一种新的血管生成抑制因子&TSF的设计及表达

TSF-a new angiogenesis inhibitory factor and its design and expression

软骨血管生成抑制因子抑制血管生成及其抗肿瘤作用的研究

The Effect of Cartilage Angiogenesis Inhibitory Factor on Angiogenesis and Tumor Growth

血管生成抑制因子arresten抑制huvec细胞增殖和迁移的实验研究

Effects of arresten on huvec cell proliferation and migration

血管生成抑制因子arresten克隆及功能的初步研究

Preliminary Study on Cloning and Functions of Human Arresten Gene

目的构建血管生成抑制因子arresten的真核表达细胞克隆体系。

Objective To construct the eukaryotic expression of arresten in CHO cell .

血管生成抑制因子arresten是血管生成及肿瘤生长抑制物。

Arresten has been identified as an inhibitor of angiogenesis and tumor growth .

目的克隆表达血管生成抑制因子arresten基因，并探讨其生物学活性。

Objective To clone human arresten gene and investigate biological activity of the recombinant protein .

血管生成抑制因子arresten基因的克隆表达

Cloning and Expression of Human Arresten Gene

肿瘤血管生成抑制因子Arresten基因克隆及其对烟草的转化

Cloning of the gene coding for tumor angiogenesis inhibitor Arresten and its transference to Nicotiana tabacum

结论：Endostatin与VEGF的表达水平随着卵巢癌临床分期的进展而升高，反映了卵巢癌疾病发展过程中血管生成抑制因子和促进因子之间的平衡调节。

Conclusion : The fact that the expression of endostatin and VEGF increases with clinical stages in the progression of ovarian cancer reflect the balance regulation between the angiogenesis inhibitors and promoters .

纤溶酶原K13功能区是近年发现的血管生成抑制因子，具有抑制肿瘤生长和转移的活性。

Kringle 1-3 domain is a recently found angiogenesis inhibitor with anti-angiogenesis and anti-tumor activity .

目的：探讨血管生成抑制因子arresten对人脐静脉内皮细胞HUVEC增殖和体外血管腔形成的影响，了解其抑制血管生成的途径。

Objective : To investigate the effect of arresten , an inhibitor of angiogenesis , on human umbilical vein endothelial cell ( HUVEC ) proliferation and tube formation in vitro and understand its action pathway .

目的探讨脑组织特异性血管生成抑制因子1（BAI1）对胶质母细胞瘤的治疗作用及其作用机制。

Objective To study the therapeutic effects of brain - specific angiogenesis inhibitor 1 ( BAI 1 ) on human glioblastoma and relevant mechanism .

目的：构建内源性血管生成抑制因子Arresten基因的原核表达载体，优化表达条件，初步探讨表达蛋白的抑制血管活性。

Objective : In order to construct prokaryotic expression vector for endogenetic angiogenesis inhibitor Arresten gene and to optimize the expression condition , in the same time to investigate initially the anti-blood vessel activity of the expressing protein .

人纤溶酶原饼环区5（hPgnK5）是新的血管生成抑制因子。

The human plasminogen kringle 5 is a novel angiogenesis inhibitor .

血管生成抑制因子人内皮抑素基因的克隆与原核表达

Human angiogenesis inhibitor endostatin gene cloning and expression of pronucleus

鲨鱼软骨血管生成抑制因子的纯化和功能

Purification and Functional Characterization of a Shark Cartilage Factor Inhibitory to Angiogenesis

基因重组鲨鱼软骨血管生成抑制因子的发酵条件优化

The optimization of the recombinant Shark Cartilage Angiogenesis Inhibiting Factor 's fermentation conditions

血管生成抑制因子研究

Study on the Angiogenic Inhibition Factors irom Shark Cartilage

血管生成抑制因子产生机理的研究

Mechanism of Angiogenesis Inhibitor Generation

内源性血管生成抑制因子的研究进展及在肝癌中的应用前景

Recent Progress of Studies on Endogenous Angiogenesis Inhibitive Factors and Their Possible Effect in Therapy of Hepatocarcinoma

结论应用内源性血管生成抑制因子的研究，对肝癌的防治将有积极的意义。

Conclusion Recent studies on endogenous angiogenesis inhibitive factors will be helpful in the prevention and treatment of hepatocarcinoma .

近年来，研究发现了多种内源性血管生成抑制因子，其中一些已进入了临床试验阶段。

Recently , many endogenous angiogenesis inhibitors have been discovered , some of them are currently in various stages of clinical trials .

本文对内源性血管生成抑制因子的结构、功能、作用机制及其在肿瘤治疗中的应用进行综述。

This review focused on the structure , function , and mechanism of endogenous angiogenesis inhibitors , and their potential in treating tumor .

由于内源性血管生成抑制因子显示出抑制瘤床内皮细胞增殖的高度选择性，因此被认为是抗血管生成治疗中最有潜力的药物蛋白质，寻找内源性的血管生成抑制因子成为近年来研究的热点。

Since the endogenous angiogenesis inhibitor showed highly selective in inhibiting the proliferation of the tumor bed , it was reasonably to be considered the most potential protein drug for anti-angiogenic therapy .

近年来对CNV机制的学说有角膜水肿学说、缺氧学说、新生血管生成因子和抑制因子之间失衡学说及炎症细胞浸润学说等。

Recently there are many hypothesis about the pathogenesis of CNV such as corneal edema , hypoxia . disbalance between angiogenesis factor and anti angiogenesis factor , infiltration of inflammatory cells .

检测肿瘤组织或血清、尿等多种体液中血管生成刺激和抑制因子，可提供反映肿瘤血管生成活性的信息，有可能成为预示肿瘤发展、转移及预后的新的敏感指示剂。

Measuring the levels of some main stimulators and / or inhibitors of angiogenesis in solid tumors or in the serum or urine may reflect the information about tumor angiogenesis activation , further provides new and sensitive markers for tumor progression , metastasis and prognosis .

鸡胚CAM可作为研究EC移动和增殖的体内模型，用于血管生成刺激因子和抑制因子的筛选和研究。

So a conclusion may be drawn that chick embryonic CAM can be used as an in vivo model to investigate EC migration and proliferation , furthermore , to detect angiogenesis promoters and inhibitors .

Canstatin是一种来源于Ⅳ型胶原α2链非胶原（NC1）区的血管生成和肿瘤生长抑制因子。

Canstatin is a novel inhibitor of angiogenesis and tumor growth , derived from the C-terminal globular non-collagenous ( NC1 ) domain of the α 2 chain of type ⅳ collagen .

肿瘤新生血管的生成主要是血管生成因子与血管生成抑制因子之间的失衡造成的，具有非常复杂的遗传机制和环境因素。

Tumor angiogenesis takes place with imbalance between angiogenic factors and angiogenic inhibitors . Tumor angiogenesis is induced by complex genetic mechanism and environmental factors .