西布曲明

目的：观察单纯性肥胖患者血清IL-6水平及西布曲明减重治疗对其的影响。

Objective : To study the change of serum interleukin 6 levels in obese patients and effect of sibutramine on its levels .

目的为保证新药轻灵盐酸西布曲明（Qlsibutramine）的临床用药安全，评价其生殖毒性，进行了大鼠致畸试验。

Purpose : To assess the safety of Qingling sibutramine hydrochloride ( Ql sibutramine ) on the reproduction and development of rats .

西布曲明（15，30mg／kg，ip.）

Fluoxetine ( 15 and 40 mg / kg , i.p. )

方法考察了有机改性剂种类、比例、缓冲盐浓度、pH值、柱温以及流速等因素对西布曲明对映体拆分的影响，并对拆分机理进行了探讨。

Methods Influences of the pH values of the mobile phases , the organic modifiers , the buffer concentration , the flow rates and the column temperature on the enantiomeric separation were investigated .

对于那些希望自今天FDA顾问委员会关于雅培减肥药西布曲明的会议得到一个非常清楚信号的人：对不起的。

To those hoping for a clear-as-a-bell signal from today 's FDA advisory committee meeting on Abbott 's weight-loss drug Meridia : sorry .

“我们继续相信有合适的和可以确认的患者获得益处”自西布曲明，该公司全球制药发展副主席EugeneSun说。

" We continue to believe that there are appropriate and identifiable patients that derive benefit " from Meridia , said Eugene Sun , the company 's vice president of global pharmaceutical development .

星期三发表的所谓SCOUT研究的最终数据表明西布曲明增加已患心脏病的患者的心脏病发作和中风的风险。

Final data from the so-called SCOUT study , published on Wednesday , showed Meridia increases the risk of heart attacks and strokes in patients who already have heart disease .

方法：测定35例单纯性肥胖患者服用西布曲明前后体重指数（BMI）、腰臀比（WHR）及血清瘦素、胰岛素水平的变化。

Methods : The body mass index ( BMI ), waist hip ratio ( WHR ), plasm leptin and insulin levels of the 35 obese subjects were determined before and after treated with sibutramine .

西布曲明片剂的相对生物利用度F0-72为（96.24±16.74）%。

The relative bioavailability F0-72 was ( 96.24 ± 16.74 ) % .

采用非手性的C18色谱柱，通过在流动相中加入手性选择剂β-环糊精的方法实现西布曲明对映体的拆分。

By adding β - cyclodextrin as chiral selector into mobile phase , sibutramine enantiomers were separated using non-chiral C_ ( 18 ) column in high performance liquid chromatography ( HPLC ) .

研究表明，用DMTA进行拆分时，在乙酸乙酯中可析出非对映异构体盐，对其进行重结晶和解离后得到光学纯西布曲明。

Among them , when using DMTA as resolving agent , the salt of non-enantiomer can be facilely precipitated in ethyl acetate . Followed by recrystallization and dissociation , optically pure sibutramine was obtained .

结果：西布曲明可明显减少受试者的腰围、臀围、BMI、体重（P<0.01），总有效率为73.8%，对照组为15.5%，P<0.01。

RESULTS : Sibutramine could obviously reduce the waist circumference , hip circumference , BMI , body mass ( P < 0.01 ) . The total effective rate was 73.8 % in treatment group while that was 15.5 % in placebo controlled group ( P < 0.01 ) .

目的：评价西布曲明（sibutramine）对单纯性肥胖或体重指数（BMI）≥25的超重者的减肥疗效及安全性。方法：以安慰剂作为对照进行8wk的随机双盲、多中心临床研究；

AIM : To evaluate the efficacy and safety of sibutramine for simple obesity or overweight with body mass index ( BMI ) no less than 25 . METHODS : Double-blind randomized controlled multicenter clinical trial for 8 wk was conducted compared with placebo .

方法采用多中心、开放的方法对481例年龄在18-65岁、体重指数>25kg/m2的受试者进行为期24周的临床观察：低热卡饮食的同时每日口服盐酸西布曲明胶囊10mg。

Methods The clinical data of 481 obese subjects , with the BMI > 25 kg / m , aged 18 - 65 , in 8 centers treated by sibutramine 10 mg everyday with a low calorie diet for 24 weeks were collected and analyzed .

建立食源性肥胖大鼠动物模型90只，分为15Hz电针组、2/15Hz电针组、手捻针组、西布曲明治疗组、束缚对照组。

A rat model of alimentary obesity was set up . The 90 rats were divided into 15 Hz electroacupuncture , 2 / 15 Hz electroacupuncture , manual acupuncture , Meridia treatment and binding control groups .

盐酸西布曲明片对性功能的影响

Sexual function effected by sibutramine hydrochloride during treatment for obesity

·安全方面。盐酸西布曲明治疗单纯性肥胖的疗效与安全性

Efficacy and safety of sibutramine in simple over - weighted and obese subjects

西布曲明对肥胖伴糖脂代谢异常的治疗作用

Effect of sibutramine on the obesity with metabolic disorder of blood glucose and lipid

探讨性别对西布曲明片减肥疗效的影响

Effect of sex on weight loss with sibutramine

国产西布曲明对超重和单纯性肥胖患者的近期疗效及安全性分析

Efficacy and safety of sibutramine in treatment of patients with overweight and simple obesity

小鼠代谢综合征模型的特征及西布曲明的治疗作用研究

Study on the characteristics of metabolic syndrome model in mice and therapeutic effect of sibutramine

在检测的20种样品中，检出含有西布曲明的样品13个，检出率为65%；

Sibutramine was detected in13 of20 samples , and namely the detection ratio was65 % .

西布曲明胶囊治疗单纯性肥胖

Sibutramine capsules for treatment of simple obesity

首先用盐酸西布曲明制备出实验用西布曲明，然后用D-樟脑-10-磺酸进行拆分。

The sibutramine was prepared from sibutramine hydrochloride , its resolution was proceeded using D-camphor-10-sulfonic acid .

目的：评价盐酸西布曲明治疗单纯性肥胖患者的疗效与安全性。

Objective To evaluate the efficacy and safety of sibutramine in simple over weighted and obese subjects .

减肥药奥利司他和西布曲明对心血管疾病危险因素及游离睾酮水平的影响

The effects of Xenical and Sibutramine on the risk factors of cardiovascular disease and free testosterone level

西布曲明对肥胖患者左心室结构与功能超声检测异常的影响

Effect of sibutramine on the ultrasound detected abnormalities of left ventricular structure and function in obese patients

西布曲明治疗6个月可降低肥胖患者血清游离脂肪酸水平

Level of Free Fat Acid Could be Decreased in Obese Subjects after 6 Months ' Treatment with Sibutramine

对于西布曲明导致的骤死、心脏衰竭、肾衰竭和胃肠不适就问题的研究一直在进行中。

Studies are ongoing into reports of sudden death , heart failure , renal failure and gastrointestinal problems .

通过衍生反应，建立了用荧光光度法测定盐酸西布曲明的新方法。

Based on derivative reaction , a new derivative fluorescence method is developed for the determination of sibutramine hydrochloride .