连锁不平衡

人类混血群体连锁不平衡的遗传学模型与基因定位

Gene Mapping and Genetics Model of Linkage Disequilibrium in Half-bred Human Population

精神分裂症患者中单胺氧化酶A和B多态性位点的连锁不平衡研究

Study on Linkage Disequilibrium Between Polymorphic Loci for Monoamine Oxidases A and B in Schizophrenia

在这11个微卫星位点中，有2个位点明显偏离哈迪-温伯格平衡（Hardy-WeinbergEquilibrium），两个位点对之间存在显著的连锁不平衡。

Two loci showed significant deviations from Hardy-Weinberg equilibrium . Two locus pairs exposed significant linkage disequilibrium .

同时，本文提出了一个在Hardy-Weinberg平衡群体中，利用连锁不平衡估计EM和phase算法推断多位点杂合个体单倍型准确性的方法。

A method is proposed to formulate the relationship between accuracy of phase , EM algorithm and LD in Hardy-Weinberg populations .

连锁不平衡（LD）应用于某些复杂疾病基因的定位。

Linkage disequilibrium ( LD ) has been employed to help in the identification of genes underlying some complex diseases .

本文中所实现的选择标签SNP的算法是以连锁不平衡（linkagedisequilibrium，LD）为基础的。

This article mainly carries out the algorithm finding tag SNP from SNP based on Linkage Disequilibrium ( LD ) .

中国人群β珠蛋白基因簇RFLP连锁不平衡及其在产前诊断中的意义

Linkage Disequilibrium of RFLP on Beta-Globin Gene Cluster and Its Significance in Prenatal Diagnosis of Beta-Thalassemia

重庆人群IL-1β启动子区-31、-511、-1470单核苷酸多态性位点间的连锁不平衡分析

Linkage disequilibrium analysis of - 31 , - 511 , - 1470 single nucleotide polymorphisms in the promoter of IL-1 β in Chongqing population

该指数可以度量标记基因和性状位点间连锁不平衡（LD）程度。

The index can quantify the level of linkage disequilibrium ( LD ) between the marker and the disease susceptibility locus ( DSL ) of genes .

结论：（l）两对等位基因紧密连锁不平衡；

Conclusion : ( 1 ) there is strong linkage disequilibrium between the two polymorphism loci ;

在关联分析中，SNP的最终价值很大程度上取决于其在人群中的频率分布以及彼此之间的连锁不平衡状况。

The ultimate value of SNPs for linkage and association mapping depends in part on the allele frequencies of the markers and inter-marker linkage disequilibrium across populations .

强直性脊柱炎患者MICA基因第2、3和4外显子的多态性及其与HLA-B抗原的连锁不平衡

Disequilibrium linkage between the polymorphism in exons 2 , 3 and 4 of the MICA gene and HLA-B antigen of patient with ankylosing spondylitis

结论：上述RFLP片段在本组散发性颅内动脉瘤患者和其它神经外科疾病患者之间不存在遗传学上的连锁不平衡。

Conclusion : there , are no linkage disequilibrium of above detected RFLP fragments between the sporadic aneurysm patients and other neurosurgical patients in this investigation .

通过对栽培稻Waxy基因的序列多态性进行连锁不平衡分析，发现在全基因区域都存在较强的LD结构。

Based on the analysis of linkage disequilibrium about the sequence polymorphisms of Waxy gene in the cultivated rice accessions , strong LD structure was identified through the entire region of this gene .

遗传不平衡系数、连锁不平衡系数和配子间遗传共适应概率与x2适合性检验结果相一致。

The coefficients of genetic disequilibrium , linkage disequilibrium and the probability of genetic co-adaptation between gametes corresponded to the conclusions drown from chi-squared tests of goodness-of-fit .

结论Bcl2基因多态与SLE发病相关，其可能直接参与SLE发病或与附近某个易感位点存在连锁不平衡。

Conclusion Bcl 2 gene polymorphism is associated with SLE and may be directly involved in the process of SLE or in linkage disequilibrium with some susceptibility loci nearby .

多巴胺D2受体基因启动子A-241G多态性在精神分裂症家系中的连锁不平衡传递

Association between A-241G polymorphism of dopamine D_2 receptor promoter gene and schizophrenia in Chinese

结论浙江地区汉族人群caspase-3基因上的3个SNP位点间存在强连锁不平衡，它们构成的主要单倍型不同于北美人群。

Conclusion The above findings indicated there is strong linkage disequilibrium among the three SNPs in caspase 3 gene in Han nationality of Zhejiang province and the main haplotype of Han nationality is obviously different from that of North American .

结论汉族人群β-纤维蛋白原基因5个SNP位点之间存在着有意义的单倍型和连锁不平衡关系，并且单倍型CA、CA以及CG可能降低脑梗死的发病率。

( Conclusion ) There are significant haplotypes and lin - ( kage ) disequilibrium among the five SNPs in β - fibrinogen gene in Han population . Moreover , the haplotype CA , CA and CG could lower the incidence rate for cerebral infarction .

罗泽伟等进一步发展统计分析方法检测及估算分子标记与QTL之间的连锁不平衡系数，从而提出了人类复杂遗传病高解析度基因定位的理论策略。

W. Luo developed a method that can detect and estimate the coefficient of linkage disequilibrium between a marker locus and quantitative trait locus ( QTL ), and raised the theoretical strategies for high resolution mapping of complex genetic disorders in humans .

结果LPL基因两位点间存在连锁不平衡，主要存在3种单元型：H+S、H-S和H-X。

Results Linkage disequilibrium between the two sites was observed , with three major haplotypes identified : H + S , H - S , and H - X.

同时，Wx基因表现出连锁不平衡现象，外显子2和内含子1区域所承受的选择压力较小。

At the same time , Wx gene showed the phenomena of linkage disequilibrium ( LD ) and exon 2 and intron 1 regions were subject to the least selection pressure in its entire gene sequence .

由于生物数据有它本身的特殊性，传统的单因素分析已经不能满足SNPs识别的需要，尤其是在SNPs具有强连锁不平衡性以及SNPs数量远大于样本数量的情况下。

Because of the specificity of biological data , traditional Single Locus Analysis can not meet the needs of SNPs identification , especially when the SNPs are in Linkage Disequilibrium or the number of SNPs is much larger than the number of sample .

HLA-SA-4遗传参数（包括抗原频率，基因频率，双位点单倍因频率，连锁不平衡参数）及其方差计算程序，⑤HLA-SA-5疾病相关研究中的抗原关联分析及单倍型关联分析程序。

HLA-SA-4 Program for calculation of genetic parameter and corresponding variances . 5 . HLA-SA-5 Program for antigen and haplotype association analysis in HLA and disease study .

结果：在AT1基因启动子区共发现6个SNPs，属同一单倍域，其中-810T/A多态与另4个SNPs（-713G/T、-214A/C、-213G/C和-153A/G）几乎呈完全的连锁不平衡。

Results Six SNPs were discovered to belong to one haplotype block , among which - 810T / A polymorphism was almost in the complete linkage disequilibrium with - 713G / T , - 214A / C , - 213G / C and - 153A / G polymorphisms .

对ⅣS6+G82A与Pro303Pro进行了连锁不平衡分析（D′：0.441，r~2：0.027），则两位点间连锁不平衡很弱。结论：①肥胖儿童存在胰岛素抵抗和瘦素抵抗。

The linkage disequilibrium analysis was carried out for IVS6 + G82A and Pro303Pro ( D ': 0.441 , r ~ 2:0.027 ), so their linkage disequilibrium was weak . CONCLUSIONS : ① Insulin resistance and leptin resistance are present in obese children .

单核苷酸多态性与连锁不平衡研究进展

Advance in the research of single nucleotide polymorphism and linkage disequilibrium

结论在9个多态性位点之间存在连锁不平衡；

Conclusion There was linkage disequilibrium between the fibrinogen gene loci .

基于连锁不平衡的基因交互定义的推广及其检验

An Extension and Test for Gene-Gene Interaction Based on Linkage Disequilibrium

一个基因内部两个或多个多态性基因座间存在完全或近乎完全连锁不平衡相当常见。

Complete or nearly complete association between polymorphisms was frequently observed .