骨骼畸形

本实验中，共发现了24种骨骼畸形类型。

In turbot , 24 types of skeletal abnormalities were observed .

胎儿骨骼畸形的超声诊断与临床价值

Ultrasonic Diagnosis and its Clinical Application for Fetal Bone Malformation

IVA型患儿临床表现主要为生长迟缓，骨骼畸形，关节松弛，智力正常，尿GAG定量和电泳结果可正常。

The main clinical manifestations of type ⅳ A patients were growth retardation , skeletal deformities , laxity joints , normal intelligence and slightly increased or normal GAG in urine .

胸廓骨骼畸形也可能影响二尖瓣脱垂的X线诊断。

TSA can also influence prolapse of the mitral valve .

严重缺乏维生素D会导致儿童骨骼畸形，成年人骨骼脆弱。

Extreme vitamin D deficiency causes deformities in children and weak bones in adults .

此外，此病可能还会伴发肌肉骨骼畸形，心血管畸形，和生殖器畸形。

The genitalia , internal organs , and skeleton may also be negatively affected .

骨骼畸形儿童的临床研究

The Clinical Study of Children Bone Deformity

三维超声对胎儿骨骼畸形的研究

Three-dimentional Ultrasonic Study on Fetal Skeletal Dysplasia

软骨下骨吸收7例（50.0%）；骨骼畸形5例（41.6%）；

Subarticular bone absorption 7 cases ( 50.0 % ), Skeletal deformity 5 cases ( 41.6 % );

目的研究自体下颌骨外板移植在颅颌面骨骼畸形或缺损修复中的应用。

Objective To study the autogenous outer mandibular table as a bone graft in the management of craniomaxillofacial deformities .

前者出现多饮多尿更明显，后者骨骼畸形和生长发育落后更多。

The frequency of uresis in the former patients is higher while bone malformation and growth stasis are more observed in the latter ones .

病情发展过程中，患者易发肌肉和骨骼畸形、心肌症，并经历呼吸紊乱和智力损伤。

As DMD progresses , patients are also subject to muscular and skeletal deformities and cardiomyopathy and may also experience breathing disorders and intellectual impairment .

为探讨低磷抗维生素D佝偻病早期诊断及适宜治疗方法以减轻严重骨骼畸形及发育迟缓。

To discuss an early diagnosis and a proper therapy for hypophosphatemia and vitamin D-resistant rickets so as to relieve severe bone deformity and developmental retardation .

下颌偏斜畸形表现程度随生长发育逐渐加重，从替牙期到恒牙期有从下颌移位向真性骨骼畸形发展的趋势。

Display degree of mandibular lateral deformity is aggravating gradually to grow at the same time , which is development trend from mandible shift to the genuine skeleton deformity .

尽管已有的证据都表明了现有研究是如何在实验小鼠身上发现胎儿骨骼畸形等一些问题的，可高露洁公司依然以这些研究的对象是动物为由，认为这些结果没有相关性。

Despite evidence - including pages in the report showing how tests found fetal bone malformations in mice and rats - Colgate deemed the results irrelevant because they were conducted on animals .

结论超声检查可提示胎儿致死性和严重骨骼畸形的形态学特征，为产科合理干预提供可靠诊断依据，具有临床应用价值。

Conclusions Ultrasonic examination can point out morphological characteristics of fatal structures and serious bone malformations and provide a diagnostic basis for obstetric intervention , and be valuable for minimizing the neonatal mortality .

孩子们如果得不到足够的维生素D，就有患佝偻病的危险。佝偻病是一种软骨病，如果在孩子小时候得不到医治，就会造成发育受阻和骨骼畸形。

Children who do not get enough vitamin D are at risk for rickets , a bone-softening disease that results in stunted growth and skeletal deformities if not corrected while the child is young .

成人骨性Ⅲ类错合畸形可通过正颌外科手术治疗达到颌骨的Ⅰ类关系，面部软组织侧貌得到明显改善，对骨骼畸形的矫治效果明显优于非手术治疗。

Skeletal ⅲ malocclusion treated with orthodontic and orthognathic surgery could achieved class I skeletal pattern and soft tissue profile could be dramatically improved . Treatment effect of orthognathic surgery on skeletal deformity was obviously better than non-surgical treatment .

CCF大鼠软骨组织内IGFBP-6的高表达可能与骨骼发育畸形的发生密切相关。

The higher gene expression of IGFBP-6 may be induced the developmental skeleton defect in CCF rat .

结果在5～15μg/kgTCDD浓度下诱导了大鼠骨骼发育畸形，并存在剂量依赖性生物学效应；

Results TCDD at the concentration of 5-15 μ g / kg induced developmental skeleton defect of fetal rat , and the effect was dose-dependent .

结论在高雌激素水平下，TCDD可以诱导大鼠骨骼发育畸形；

Conclusion These findings provide the evidence that TCDD can induce congenital fetal skeleton malformation under the condition of high estrogen level in pregnant Wistar rats .

在WNT家族及其作用途径的相关信号分子中，无论何种亚型或分子的异常表达都可能破坏WNT系统维系的正负平衡机制，导致骨骼系统畸形。

However , both the members of WNT family and their related molecules in the signaling pathway expressing abnormally can disrupt the balance remained by the WNT family and result in skeleton malformation .

胎鼠外观和骨骼出现畸形。

The appearance and bones of embryo appeared malformed .

这对儿童来说，不仅影响美观，还会导致全身骨骼发育畸形。

For this pair of children , affect not only beautiful , still can bring about deformation of systemic skeleton development .

结果2例患者均以颈肌无力起病，以后四肢和躯干肌不同程度受累，无骨骼发育畸形。

Results These two patients were found with an initial onset from neck muscle weakness at the age of 52 and 36 years respectively , followed by trunk and limb muscle involvement to a variant degree . development ;

各剂量组没有观察到胎仔内脏及骨骼系统的畸形。

No malformation of organs and bones was observed .

维甲酸大鼠是研究骨骼先天性畸形的实用工具模型。

The rat model of retinoic acid is a useful tool for investigation of congenital skeletal mal-formations .

76%先天性成骨不全为多发性畸形，以合并骨骼系统的畸形多见。

The associated abnormalities accounted for 76 % of the cases , most of which involved the skeletal systems .

为了减少因手术造成的各种并发症的发生，避免手术损伤，人们一直在探讨非手术治疗骨骼肌肥大畸形的方法。

For preventing the complications and avoidance of surgical damage , some no surgical methods have been tried for the treatment of benign masseter hypertrophy .

咬肌肥大等骨骼肌肥大畸形的治疗一直以手术切除部分肥大的咬肌作为主要治疗手段。目的：进一步探讨咬肌的血供及血管构筑，为咬肌下颌角良性肥大畸形矫正术提供形态学依据。

Masseter hypertrophy is usually treated by surgical procedures . Objective To explore the blood supplying system and its vessel architecture of the masseter , and to provide anatomic basis for plastic surgery of masseter hypertrophy .