IKK

Besides IKK β is also associated with chronic inflammatory disease and some types of cancers .

此外IKKβ与其他疾病特别是慢性炎症疾病、癌症等疾病也相关。

This article reviews the structure , function and the relationship to the tumorigenesis of the IKK .

本文综述了IKK的结构、功能，及其与肿瘤发病的关系。

The Effect of Smoking and Smoking Cessation on Content of IKK β Protein in Type 2 Diabetes Rats

吸烟和戒烟对糖尿病大鼠IKK-β蛋白含量的影响

Thus , precise control of IKK phosphorylation is a crucial component of NF - κ B signaling .

因此，对IKK复合体磷酸化的精确调控是NF-κB通路信号传导的重要组成部分。

Effect of Extract of Ginkgo biloba on Signal Pathway of IKK / NF - κ B in Asthma Rats

哮喘大鼠IKK/NF-kB信号通道及银杏叶提取物的调控作用

Immunohistochemistry method was used to detect the PKC - δ and IKK - β staining reaction of hippocampal tissue .

免疫组织化学法检测了每组大鼠海马组织PKC-δ和IKK-β的免疫染色反应。

In addition , there are many researches have showed that the composed activation of IKK is very closed associated with cell malignant transformation .

此外，有很多研究也表明，IKK的组成性活化和细胞的恶性转化有密切关系。

Conclusion Effects of IKK - β / NF - κ B / TNF-a might play an important role in inflammatory reaction of traumatic ALI ;

结论IKK-β/NF-κB/TNF-α效应在创伤性ALI的炎症反应中发挥重要作用。

Recently IKK ε as a member of the IKK family discovered are highly expressed and plays an important role in malignant transformation in many tumors .

IKKε作为IKK家族新近发现的成员，在众多肿瘤中被确认高表达且在它们的恶性转化中起着重要作用。

Excess ROS pathway through the activation of IKK , etc. , interfere with insulin receptor signal transduction , leading to insulin resistance . 4 .

过量的ROS通过激活IKK等通路，干扰细胞胰岛素受体信号转导，导致胰岛素抵抗。

Correlation between the signal pathway IKK / NF - κ B and the anti-oxidant activity in asthma rats and the modulation of Ginkgo biloba extract

哮喘大鼠IKK/NF-κB信号通道与抗氧化性的关系及银杏叶提取物的调控

IKK and Diabetic Nephropathy

IKK与糖尿病肾病

CONCLUSION : The expression imbalance of IKK , I κ B and NF - κ B is closely associated with the genesis and development of laryngeal carcinomas .

结论：IKK，IκB和NFκB表达失衡与喉癌的发生发展有着密切关系。

Objective To investigate the significance of IKK β in acute lung injury ( ALI ) following hemorrhagic shock ( HS ) and the protective effect of Anisodamine ( 654-2 ) .

目的探讨IκB激酶β（IKKβ）在失血性休克继发急性肺损伤中的意义及山莨菪碱（6542）的干预作用。

Protein and mRNA of IKK - β on liver and fatty tissue increased in model , which may be an important mechanism from chronic pancreatitis , insulin resistance on leading to pancreatogenic diabetes .

慢性胰腺炎大鼠肝脏和脂肪组织IKK-β的表达增加，可能是慢性胰腺炎胰岛素抵抗继发胰源性糖尿病发生的一个重要机制。

By statins , ARB class of drug intervention , can ROS , IKK expression levels such as reduction , improved markedly improved insulin resistance , in which statins reduce the more obvious .

通过他汀类、ARB类药物干预，可使ROS、IKK等表达水平下调，明显改善胰岛素抵抗，其中他汀类降低更为明显。

During the course of NF κ B dimer activation , I κ B kinase ( IKK ) play a crucial role by phosphorylation of inhibitory κ B ( I κ Bs ) .

在NFκB二聚体活化过程中，IκB激酶（IKK）通过对抑制性蛋白κB（IκBs）的磷酸化而扮演关键的角色。

Using in vitro and in vivo coimmunoprecipitation assay , we confirmed the interaction between HPD and NEMO through their N terminals , and HPD may form a protein complex with IKK complex .

采用外源和内源免疫共沉淀实验我们验证了HPD与NEMO的相互作用，确定HPD通过N端与NEMO的N端发生相互作用，并证明HPD可能与IKK组成蛋白质复合体。

Methods IKK - β specific siRNA designed from the human gene sequence was transfected into the cultured human Tenon ′ s capsule fibroblasts , and a non-targeted siRNA was transfected as a negative control .

方法采用化学合成的靶向IKKβ的siRNA，转染体外培养的人眼球筋膜囊成纤维细胞，同时以对任何基因均无作用的siRNA作为阴性对照。

AIM : To investigate the correlation between the signal pathway of IKK / NF - κ B and the anti-oxidant activity in asthmatic rats and the modulation of Ginkgo biloba extract ( Egb ) .

目的：探讨哮喘大鼠IKK/NF-κB信号通道与丙二醛（MDA）、还原型谷胱甘肽（GSH）的关系及银杏叶提取物（Egb）的调控。

METHODS : Using 4-vessel occlusion ( 4-VO ) as brain ischemia model , IKK protein expression was examined by immunoblotting and immunoprecipitation , and IKK activity was assayed by in vitro kinase assay .

方法：采用IKKα/B抗体进行免疫印迹和免疫沉淀分析，测定IKK蛋白表达，体外激酶活性分析测定IKK的自身磷酸化及活性。

The lowest level of I κ B α was notably higher than that in LPS stimulation group , while the peak of IKK β mRNA was obviously lower than that in LPS stimulation group ( P < 0.01 ) .

IκBα水平的最低值显著高于LPS刺激组（P<0.01）；而IKKβmRNA的峰值则显著低于LPS刺激组（P<0.01）。

IKK-beta , a kind of sub form of IKK , play the critical role in the activated process of NF-B. Polymyxin B ( PMB ) is a kind of antibiotics with obvious anti-endotoxin .

多粘菌素B（PMB）是一种具有显著抗内毒素作用，同时抑制IKK-β激活的抗生素。

Results NF - κ B , IKK β mRNA expressions in lead exposed HK-2 cell were significantly higher than those in no lead exposed HK - 2 cell ( P < 0.01 ), and displayed a concentration - effect manner of lead ( P < 0 . 01 ) .

结果NF-κB、IKKβ在染铅近曲肾小管上皮细胞中的表达水平均明显高于对照组（P均<0.01）；