二氢吡啶

西尼地平是新型的二氢吡啶类（DHP）钙通道拮抗剂，临床上用于治疗高血压和心绞痛；

Cilnidipine is a new dihydropyridine ( DHP ) type of calcium channel antagonist .

目的：研究二氢吡啶类钙通道阻滞剂尼卡地平对大鼠戊四唑（PTZ）化学性点燃（kindling）的拮抗作用。

Objective : To study the antagonism of dihydropyridine calcium channel blocker nicardipine against pentylenetetrazol ( PTZ ) kindling .

二氢吡啶类钙拮抗剂对大鼠胃底平滑肌5-HT受体功能的影响及其机制的研究

Effect and it 's mechanism of DHPs calcium antagonist on the 5-HT receptor of rat stomach fundus smooth muscle

尼莫地平（nimodipine，NMD）是二氢吡啶类钙离子拮抗剂，对脑血管的作用非常突出。

Nimodipine ( NMD ) is a dihydropyridine calcium channel blocker which is very effective to cerebral vessels .

1,4-二氢吡啶衍生物与CT-DNA作用方式的研究

Study on Interaction Modes Between 1 , 4-Dihydropyridine Derivatives and CT-DNA

本文研究了曙红敏化NAD（P）H的模型化合物&1-苄基-1,4-二氢吡啶菸酰胺（BNAH）光还原二苯乙二酮的反应机制及光敏剂曙红的激发态行为。

The mechanism of eosin-sensitized photoreduction of benzil with 1-benzyl-1 , 4-dihydronicotinamide , a model compound of NAD ( P ) H and the behavior of the excited states of eosin have been investigated .

用电化学方法研究了1,4-二氢吡啶衍生物（1,4-DHP）与小牛胸腺DNA（ctDNA）作用前后在玻碳电极上的电化学行为。

The electrochemical behavior of the 1 , 4-Dihydropyridine Derivatives ( 1,4-DHP ) on the GC electrode was studied by cyclic voltammetry in the absence and presence of calf thymus DNA ( CT DNA ) .

尤其是二氢吡啶作为动物体中重要的还原性辅酶NADH的活性部分更是赋予了二氢吡啶重要的生物学方面的意义。

Their biological significance has been greatly recognized since they are discovered to be the active part of NADH , the essential reducing coenzyme in animals .

结论：盐酸乐卡地平可以明显降低收缩压和舒张压，降压作用可达24h，尤其是通常二氢吡啶类钙通道阻滞剂常见的不良反应如下肢水肿、颜面潮红、头痛和眩晕等发生率很低。

Conclusion : LH has significant anti-hypertension effect and its action can be maintained for 24h with very low incidence rate of ADRs , especially the incidence rate of leg edema , flush , headache and dizziness .

根据氨或伯胺能与β－丁酮酸酯类及醛类反应产生二氢吡啶，在（332±1）nm波长处有最大吸收的原理，直接测定硫酸妥布霉素的效价。

Based on the fact that ammonia or primary amines can react with acetoacetates and aldehydes , producing dihydropyridine with an obvious absorption peak at the wavelength of 332 ± 1 nm , thus , the potency of tobramycin sulfate can be determined directly by spectrophotometry .

重点介绍了氨氯地平合成过程中的关键步骤：二氢吡啶环的两类成环反应，即Hantzsch反应和Michael加成成环反应。

The key step in the synthesis of amlodipine , cyclization of the 1,4-dihydropyridine by Michael addition reaction and Hantzsch reaction in which different amine protective groups were used , are illustrated in details .

间尼索地平（m-nisoldipine，m-Nis），系河北医科大学药物化学教研室合成的一个新的二氢吡啶类钙拮抗剂。

M-nisoldipine ( Fig.1 ), as a new dihydropyridine calcium ion antagonist , was firstly composed in School of Pharmacy , Hebei Medical University .

由美国辉瑞公司（Pfizer）开发的新一代治疗心血管疾病药物氨氯地平是第三代1,4-二氢吡啶类钙拮抗剂的典型代表，已在全世界几十个国家和地区上市销售。

Amlodipine is a kind of new drug in the treatment of cardiovascular disease developed by Pfizer . As a typical kind of the third generation 1,4-dihydropyridines calcium antagonists , amlodipine has been sold in many countries and areas in the world .

设计并合成了5个哌嗪取代二氢吡啶新衍生物，并用45Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道（PDC）Ca2+内流的影响。

Five new piperazine substituted dihydropyridine derivatives were designed and synthesized . Their inhibitive effects on potential dependent calcium ion channels ( PDC ) in rat aorta were determined by 45 Ca transmembrane influx technique .

临床应用二氢吡啶类钙通道阻滞剂的循证医学评价

Clinical Application of Dihydropyridine Calcium Channel Blockers : An Evidence-Based Review

结论：这类化合物有钙拮抗作用，作用机制可能与影响二氢吡啶类受体有关；

CONCLUSION : These compounds are possessed of calcium antagonistic properties .

第三部分：研磨法合成二氢吡啶类化合物；

The third part is synthsis of 1,4-Dihydropyridines by the grind method .

二氢吡啶类钙拮抗剂对多柔比星肾毒性的影响

Effect of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats

二氢吡啶类钙拮抗剂结构与药物动力学的定量关系分析

Study on quantitative structures - pharmacokinetic relationship of dipyridines calcium ion antagonists

无溶剂一锅法合成1,4-二氢吡啶

One - pot Synthesis of Dihydropyridines under Solvent-free Condition

结论长效二氢吡啶类钙拮抗剂具有广阔的市场前景。

Conclusion The long acting dihydropyridine calcium antagonist will have wide market prospect .

结论：二氢吡啶类钙拮抗药居广东市场的主导地位。

CONCLUSIONS : Dihydropyridine calcium antagonists dominate Guangdong market .

二氢吡啶在生物有机化学中的应用

Applications of dihydropyridines in organic and biological chemistry

二氢吡啶类钙通道阻滞剂及其药物手性研究

Dihydropyridines Calcium Channel Blockers and Chiral Drugs Research

二氢吡啶二羧酸合成酶基因在棒杆菌中的克隆与表达

Cloning and Expressing of dapA Gene in Corynebacteria

1,4-二氢吡啶衍生物的合成方法改进

Improvement on the Synthesis of 1,4-Dihydropyridine Derivatives

二氢吡啶类药物和肺保三效片组分&高效液相色谱流动相的优化

Optimization of Mobile Phase Compositions for High & performance Liquid Chromatographic Separation of Dihydropyridine Drugs

氨氯地平是新型二氢吡啶类钙通道阻滞剂。

Amlodipine ( ALDP ) is a new kind of calcium channel blocker of dihydropyridine .

水相条件下1,4-二氢吡啶衍生物的合成与芳构化

Synthesis and Aromatization of 1,4-Dihydropyridines in Water

1,4-二氢吡啶类化合物的一种氧参与芳构化反应

An Oxygen-participated Aromatization of 1 , 4-Dihydropyridines