利多卡因

目的研究利多卡因凝胶的经皮吸收动力学以及药效学。

Aim To study the cutaneous permeation kinetics and pharmacodynamics of lidocaine gel .

利多卡因能抑制这种炎性改变及NF-κB表达上调，此可能是其抑制肺炎性反应的机制之一。

Lidocaine inhibited this inflammatory response and up-regulation of NF - κ B expression .

B组宫颈旁注射利多卡因；

Group B : Lidocaine uterocervical injection ;

pH对利多卡因硬膜外麻醉效能的影响

The Influence of pH on Epidural Block Effect of Lidocaine

不同pH值条件下利多卡因对淋巴细胞β受体的影响

The effects of lidocaine on lymphocyte β adrenergic receptor at different pH

利多卡因温血心停搏液pH值对心肌的保护作用

Effects of Lidocaine Warm Blood Cardioplegia pH on Myocardial Protection

TEA组（Ⅱ），硬膜外腔注入1%利多卡因2～3mg/kg。

In group ⅱ, 1 % lidocaine 2 ~ 3 mg / kg was infused to epidural space .

第一部分：利多卡因对SD大鼠急性心肌缺血再灌注损伤保护作用研究。

Part one : Myocardial protection of lidocaine on acute ischemic reperfusion .

HPLC法盐酸利多卡因注射液含量测定的探讨

Study on the method of detemination of lidocaine hydrochloride injection by HPLC in chp 2000

不同浓度和pH利多卡因对蛙离体坐骨神经复合动作电位的影响

Effects of Lidocaine in Different Concentration and pH on Compound Action Potential of the Sciatic Nerve Isolated from Frog

比较利多卡因组与对照组在对淋球菌培养、糖发酵试验及PCR试验方面的差异。

Comparing lidocaine group with control group on neisseria gonorrhoeae culture , glucolysis test and PCR test .

采用高效液相色谱法确定了处方中醋酸泼尼松、利多卡因、尿囊素及维生素E的含量测定方法。

The contents of prednison acetate , lidocaine , allantoin and vitamin E in the ointment are determined by HPLC .

B组注入1.6%利多卡因、0.16%丁卡因合剂（16.0±4.6）ml。

In group B the mixture of 1.6 % lidocaine and 0.16 % tetracaine was poured with ( 16.0 ± 4.6 ) ml.

结果低浓度的盐酸利多卡因对精子运动参数没有明显地影响（P0.05），但浓度达到15mg/ml时精子的运动参数显著降低（P0.05）。

Results : Sperm motility was not affected by low concentration lidocaine hydrochloride . But inhibited by 15mg / ml lidocaine hydrochloride .

TEA组（T组），硬膜外注入1%利多卡因2～3mg·kg~（-1）；

In group T , 1 % lidocaine 2 ~ 3mg-kg-1 was injected to epidural space ;

复方利多卡因乳膏在PICC穿刺中镇痛效果观察

Observation on analgesic effect of compound lidocaine cream for patients accepting PICC puncturing

目的采用RP-HPLC法测定盐酸利多卡因注射液（溶剂用）的含量。

AIM In this paper a method for the determination of lidocaine hydrochloride Injection RP-HPLC was reported .

方法200例按照美国麻醉师协会（ASA）分级为Ⅰ~Ⅱ级择期手术患者，随机分为盐酸利多卡因组（A）100例，碳酸利多卡因组（B）100例。

Methords 200 cases ( ASAI - ⅱ, selective operation ) were divided randomly into two groups : lidocaine carbonate group and lidocaine hydrochloride group .

两组疗效差异无显著性（P＞0.05）。利多卡因组无明显不良反应，安定组2例出现呼吸抑制而终止治疗。

There was no significant differences between the two groups ( P > 0.05 ), no obvious untoward reactions were observed in the former group , but some respiratory inhibition was seen in the latter .

需熟练应用临时心脏起搏、直流电复律、利多卡因等防治RA。

We need well-trained application with temporary cardiac pacing , electronic diversion , lidocaine , etc. , to prevent and control RA .

利多卡因对致痛大鼠L（4～5）脊髓P物质分布影响的实验研究

Effect of intrathecal lidocaine on the substance P of L_ ( 4 ~ 5 ) spinal cord in rats after formalin stimulation

目的探讨利多卡因预处理对肝细胞缺氧/复氧后Bcl-2、Caspase-3蛋白表达及细胞凋亡的影响。

Objective To investigate the impact of lidocaine preconditioning on the expression of Bcl-2 , Caspase-3 in liver cell and apoptosis during hypoxia-reoxygenation injury .

新型BAL系统具有较强的清（白）蛋白合成和利多卡因代谢能力。

The BAL system has relatively strong albumin synthesis and lidocaine ( metabolism ) functions .

方法采用胸腔闭式引流放液，腔内注入顺铂和5-Fu，注药前腔内注射利多卡因和氟美松。

Methods Release the fluid through cavity closed drainage , and inject cisplatin and 5-Fu after the injection of lidocaine and dexamethasone .

利多卡因对DNP引发的电压依赖性钠电流变化的影响

Effect of lidocaine on the changes in voltage-dependent sodium channels induced by DNP

方法采用改良的Franz扩散池，建立了利多卡因制剂的体外经皮渗透试验方法。

Methods The experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell .

B组患者76例，于活检前5min直肠内灌注2%利多卡因凝胶10ml。

Group B ( 76 cases ) received 10 ml of intrarectal 2 % lidocaine gel 5 minutes before the procedure .

碳酸利多卡因和盐酸利多卡因的药效学参数麻醉起效时间、阻滞完善时间及麻醉持续时间分别为（4.9±1.8）和（9.1±2.1）min；

The onset time , finishing time and persistent time of blockade of the lidocaine carbonate group and lidocaine hydrochloride group were ( 4.9 ± 1.8 ) vs ( 9.1 ± 2.1 ) min ;

结论：CPB中利多卡因能降低脑氧耗，有利于改善大脑氧供需平衡和保护体外循环中缺血脑细胞的功能。

Conclusions : Lidocaine makes total cerebral oxygen metabolism reduce during CPB . It can improve cerebral oxygen balance and protect the function of anoxic cerebral cells .

结论利多卡因、异丙酚可促进再灌注期间心肌细胞膜Na+K+ATP和肌浆网Ca2+ATP酶活性的恢复，从而抑制钙超载而减轻心肌缺血再灌注损伤。

Conclusion Lidocaine , propofol could attenuate myocardial ischemia-reperfusion injury by increasing the activities of sarcolemmal Na + - K + - ATPase and SR Ca2 + - ATPase during reperfusion .