嗅细胞

气味物质分子在空气中扩散，通过嗅细胞进入大脑，而产生对气味的识别。

The spread of flavoring substance molecules in the air and its entry to people 's cerebrum through olfactory cells finally developed the recognition of different flavor .

黄目前正在开展使用胎儿施旺（氏）细胞、嗅细胞以及联合使用两种细胞的移植手术，据说该技术有强力的科学证据。

Huang is now carrying out trials with fetal Schwann cells , fetal olfactory cells and a combination of the two , which he says have a strong scientific basis .

扫描电镜观察：可见细胞间隙增宽，嗅细胞减少，嗅泡变形，嗅纤毛脱落，临床病变程度越重，电镜改变越明显。

Observation by scanning electron microscope : The olfactory vesicle changed their shape , ORNs decreased , the olfactory cilia and the microvillus of the supporting cells disappeared , accord with the observation of transmission electron microscope .

嗅鞘细胞移植联合甲基维生素B（12）修复髓鞘组织的研究

Therapeutic effects of OEC transplantation combined with methyl-vitamine B_ ( 12 ) on experimental allergic encephalomyelitis

pH和游离血红蛋白对体外培养嗅鞘细胞存活的影响

Influence of pH and Free Hemoglobin on Viability of Olfactory Ensheathing Cells in Vitro

嗅鞘细胞和神经干细胞联合移植能够明显提高AD模型大鼠的学习和记忆能力。

Transplantation of olfactory ensheathing cells and neural stem cells can significantly improve the AD model rats ' learning and memory .

NOV在嗅鞘细胞中的表达及活性检测

Expression and activity detection of NOV in olfactory ensheathing cells

NT-3基因修饰嗅鞘细胞移植促进脊髓损伤再生的研究

The Study of Implantation of Neurotrophin-3 Modified Olfactory Ensheathing Glia in Regeneration of Spinal Cord

结果：嗅鞘细胞移植后4周，患者的脊髓功能有部分改善，美国脊髓损伤学会（ASIA）运动总分由术前2分增加到4分；

RESULTS : The spinal cord function was improved partly 4 weeks after OEC transplantation . The American Spinal Injury Association ( ASIA ) motor score increased from 2 points pre-operation to 4 points post-operation ;

目的研究嗅鞘细胞（Olfactoryensheathingcells，OECs）移植对周围神经切断后脊髓及神经节内神经元的保护作用。

Objective To study the effect of olfactory ensheathing cells ( OECs ) transplantation on protecting spinal cord and neurons after peripheral nerve injury .

S100免疫荧光染色鉴定雪旺细胞和嗅鞘细胞纯度。

S-100 immunofluorescent staining was used to identify the purity of Schwann cells and olfactory ensheath cells .

目的建立体外培养纯化嗅鞘细胞（Olfactoryensheathingcells，OECs）的模型，观察OECs生长状态和形态学变化，为研究神经再生获得丰富OECs来源奠定基础。

Objective To culture and purify the olfactory ensheathing cells ( OECs ) in vitro and investigate the morphological changes of cultured OECs .

嗅鞘细胞在含Schwann细胞冻融周围神经移植物内的存活及对成年大鼠视神经再生的影响

The survival of olfactory ensheathing cells in freeze-thawed peripheral nerve graft filled with Schwann cells and its effect on axonal regeneration of adult rat optic nerve

嗅鞘细胞移植后2～8周随访，根据美国脊髓损伤学会（ASIA）脊髓损伤神经功能分类国际标准评价。方法配对分组、自身前后对照的动物实验研究。

The spinal cord function was assessed by using the American Spinal Injury Association ( ASIA ) Classification System before and 2 to 8 weeks after operation . Statistical significance levels were calculated using a one way ANOVA paired T test .

嗅鞘细胞对正常及损伤脊髓神经元的保护作用CystatinF在中枢神经系统脱髓鞘动物模型中的表达

EFFECT OF OLFACTORY ENSHEATHING CELLS ON GROWTH OF SPINAL CORD NEURONS AND ITS PROTECTIVE EFFECT ON NEURONS AFTER INJURY IN VITRO Expression of cystatin F in central nervous system of demyelinated animal model

目的观察BDNF基因转染的嗅鞘细胞（OECs）对脊髓损伤的修复作用。

Objective To evaluation of the result of transplantation of BDNF gene transfected olfactory ensheathing cells ( OECs ) to repair spinal cord injury ( SCI ) .

有血清条件培养液、Forskolin较空白对照组可以促进嗅鞘细胞的活性（P0.05），其增值效应相对缓和。

The conditioned medium consist of serum and Forskolin could promote the vitality and number of OECs compared with the control group ( P0.05 ), and their effect were moderate .

结论：大鼠嗅球细胞的凋亡与PKC的调节密切相关；推测PKC对大鼠嗅球的生长、发育起着重要的负反馈调节作用。

Conclusion : PKC was closely related with apoptosis of the olfactory cells , it should be considered that negative feedback effect of PKC on the growth of olfactory bulb in rats .

目的研究嗅鞘细胞（OECs）对体外培养脊髓背根神经节神经元生长状态的影响。

Objective To study the effects of olfactory ensheathing cells ( OECs ) on the growth vitality of cultured dorsal root ganglion neurons from rats .

近年来，嗅鞘细胞（Olfactoryensheathingcells，OECs）以其独特的生物学特性和促进损伤脊髓轴突再生的作用在细胞移植中独树一帜，成为治疗SCI的最佳疗法之一。

In recent years , olfactory ensheathing cells ( OECs ) with its unique biological characteristics and the promotion of axon regeneration of spinal cord injured is considered the best therapy for SCI in cell transplantation .

第一部分嗅鞘细胞的体外培养、纯化及鉴定目的：纯化培养和鉴定成年大鼠嗅球嗅鞘细胞（olfactoryensheathingcellsOECs），为后续实验做好准备。

Part 1 Culture , purification and identification of olfactory ensheathing cellsObjective : To culture and purify olfactory ensheathing cells ( OECs ) . Methods : The olfactory nerve layer of adult rat olfactory bulb was dissected .

嗅鞘细胞移植治疗Friedreich共济失调疗效及可能机制探讨

Outcome and probable mechanism of olfactory ensheathing cell transplantation for treating Friedreich ataxia

结果：换无血清培养液后，成纤维细胞迅速死亡，S100免疫荧光染色雪旺细胞和嗅鞘细胞的纯度可达98%～99%。

Results showed that fibroblast rapidly died in free-serum media , the purity of Schwann cells and olfactory ensheath cells were up to 98 % ~ 99 % using immunofluorescent staining .

目的：对文献报道的嗅鞘细胞（OECs）纯化方法进行改进，为基因治疗和细胞移植修复脊髓损伤实验研究提供高纯度的种子细胞。

Objective : To improve the method of culture and purification of olfactory ensheathing cells ( OECs ) for gene therapy or cell transplantation in injuried spinal cord repair .

近年来对SCI的研究主要集中在损伤后期组织再生方面，如神经干细胞移植或嗅鞘细胞移植等，但收效甚微。

These years the research about SCI has been focused on the tissue regeneration during the late stage of injury , for example , the transplantation of neural stem cells or olfactory ensheath cells , with not many effects .

目的研究嗅鞘细胞（OEG）移植后在体内存活情况以及对大鼠脊髓损伤长期的修复作用。

Objectives To observe olfactory ensheathing glia ( OEG ) survival and repair in vivo for spinal cord injury after OEG transplantation .

目的：嗅鞘细胞（Olfactoryensheathingcells，OECs）植入脊髓后可促进再生的轴突长入远段脊髓，观察人胚胎嗅鞘细胞移植对成鼠脊髓轴突再生的影响。

AIM : To observe the effect of implantation of human embryonic olfactory ensheathing cells ( OECs ) on transected spinal cord of adult rats based on the accelerating effect of implantation of human OECs on the growth of regenerated axons into distal segmental spinal cord .

NF200和GAP43阳性神经纤维末端向嗅鞘细胞分布区偏转，而对照组并未见上述现象。

In addition , the terminus of NF200-and GAP43-positive nerve fibers turned to the OECs . However , this was not found in the control group .

25d则仅为50%。结论：应用延迟差速贴壁法与阿糖胞苷化人胚嗅鞘细胞的方法，分离培养人胚嗅球成鞘细胞是一种较为稳定可靠的方法。

Positive rate of cellular staining decreased to 90 % on day 14 and only 50 % on day 25 . CONCLUSION : Delayed differential attachment combined with cytosine arabinoside-treated human embryonic olfactory ensheathing cells method is stable and reliable in isolation and culture of human embryonic olfactory ensheathing cells .

结论：嗅鞘细胞可在冻融周围神经移植物中存活2￣3wk，神经周边部位较实质内更有利于嗅鞘细胞生长，这种移植物不能发挥促进视神经再生的作用。

CONCLUSION : The OECs can survive for 2 ~ 3wk in the freeze-thawed PN grafts with the peripheral areas being more beneficial for the survival and growth of OECs . Such freeze-thawed PN grafts can not promote the axonal regeneration of RGCs .