尼莫地平

尼莫地平（nimodipine，NMD）是二氢吡啶类钙离子拮抗剂，对脑血管的作用非常突出。

Nimodipine ( NMD ) is a dihydropyridine calcium channel blocker which is very effective to cerebral vessels .

Ⅲ组27例（27耳），全部用尼莫地平或氟桂利嗪口服，丹参制剂肌肉注射或口服，并用神经结构保护剂，不用HBO。

Nimodipine or flunarizine were given by oral administration , red sage root injection was given through im and HBO was not used in group III.

尼莫地平对戊四氮致痫大鼠海马核转录因子-κB蛋白表达的影响

Effect of Nimodipine on Expression of NF - κ B in Hippocampus of Epileptic Rats

C组：缩窄子宫动脉，术后予尼莫地平治疗。

Group C : partial occlusion of bilateral uterine artery , with nimodipine treament after operation .

pH敏感性尼莫地平水凝胶的制备及其性能研究

Preparation and behavior of pH-sensitive chitosan-sodium alginate hydrogel of nimodipine

重型颅脑伤病人脑脊液钙调素、血栓素B2含量的变化及尼莫地平的临床作用

Changes of calmodulin and thromboxane B_2 contents on CSF of patients with severe injury and action of Nimodipine

HPLC法测定血浆中尼莫地平含量。

Nimodipine concentration in human plasma was determined using a HPLC method .

尼莫地平对糖尿病大鼠海马突触素蛋白和mRNA表达的影响

Effect of Nimodipine on the expression of synaptic protein and mRNA in diabetic rat hippocampus

SOD与尼莫地平对窒息幼兔脑组织的保护作用

Protective effect of SOD and nimodipine on cerebral injury of asphyxial young rabbit

人肝微粒体中尼莫地平及其脱氢代谢物的HPLC测定法及代谢动力学

Determination of nimodipine and its dehydrogenation metabolite in human liver microsome by HPLC and its metabolizing kinetics

Beagle犬血浆中尼莫地平的HPLC法测定及其药动学

Determination of Nimodipine in Beagle Dog Plasma by HPLC and Its Pharmacokinetics

脑SPECT灌注显像用于尼莫地平疗效的评价

The clinical evaluation of nimodipine treatment by SPECT brain perfusion imaging

HPLC法测定尼莫地平脂肪乳中主药的含量籼米为基质脂肪替代品的组分含量分析与测定

Determination of Main Component in Nimodipine Emulsion by HPLC Composition Analysis of Long Grain Rice Based Fat Substitutes

经过SAS统计分析软件进行配对t检验，A、B二组服药后血流参数均明显提高，差异具有显著性。结论：尼莫地平能有效地改善开角型青光眼视神经乳头筛梅区的血流。

Conclusions : Nimodipine can effectively improve the blood flow of optic papilla laminar region in open angle glaucoma .

尼莫地平注射液对大鼠体外循环后海马bcl-2及BAXmRNA表达的影响

Effects of nimodipine injection on expressions of hippocampal bcl-2 and bax mRNA after cardiopulmonary bypass in rats

脑梗塞患者尼莫地平治疗前后TCD对照研究

TCD Comparative Study on the Infarction Patients by Using Nimodipine

尼莫地平对HL-60细胞凋亡的影响及其机制

Effect of nimodipine on HL - 60 cell apoptosis and its mechanism

目的：探讨尼莫地平（nimodipine）对动脉压力感受器反射的影响。

AIM : To study the effect of nimodipine on arterial baroreflex .

尼莫地平对阿尔茨海默病大鼠脑组织NO、NOS含量及行为学的影响

Effects of nimodipine on brain NO and NOS levels and behavioral science in Alzheimer disease rats

尼莫地平治疗组脑组织内皮素（endothelin，ET）含量明显降低，神经元损害亦明显减轻。

After nimodipine treatment , the level of brain endothelin was significantly lowered and the neuronal damages attenuated .

蛛网膜下隙出血后血浆NO、ET含量变化及氨甲苯酸、尼莫地平对其影响

Changes of NO , ET Content in Plasma after Subarachnoid Hemorrhage and Effect of Aminomethylbenzoic Acid and Calcium Antagonists on Them

目的：探讨尼莫地平联合抗栓药物治疗短暂性脑缺血发作（Transientischemicattack，TIA）的临床疗效及作用机制。

Objective : To investigate the effect and the mechanism of Nimodipine with anti-thrombus drugs on transient ischemic attack ( TIA ) .

尼莫地平对下丘脑神经元内c-fos表达的影响

Effect of nimodipine on calcium influx of hypothalamic neurons in expression of c fos protein

结果：尼莫地平组疗效均优于对照组（P＜0.05或P＜0.01）。

RESULTS : The nerve functional defect scores of the treatment group decreased more than those of the control group at the end of the 4th wk ( P < 0.05 ) .

阿司匹林+尼莫地平合用组给予阿司匹林2.35mg/（kg·d）、尼莫地平2.82mg/（kg·d）。

The rabbits in the aspirin + nimodipine group were treated with 2.35 mg / kg aspirin and 2.82 mg / kg nimodipine every day .

尼莫地平的胰液浓度高峰时间为用药后1.5～2小时，最高浓度为9.21ng／ml。

The highest value of Nimodipine level in pancreatic fluid were 9.21 ng / ml at 1.5 to 2 hours following Nimodipine taken orally .

目的研究尼莫地平/磺丁醚β环糊精（SBE7βCD）包合物的理化性质，为制剂开发提供依据。

OBJECTIVE The physical properties of inclusion complex of nimodipine / SBE 7 β CD were investigated for the purpose of reasonable development of Nimodipine formulation .

HPLC-MS法对两种尼莫地平制剂的生物等效性的研究

Studies on bioequivalence of two nimodipine tablets in healthy volunteers by HPLC-MS

结论：尼莫地平是治疗SAH和CVS最重要的有效药物，能改善CVS患者的预后，并提倡尽早使用以及合理的给药途径，使其达到最佳的治疗效果。

Conclusions Nimodipine can improve prognosis of patients with CVS and SAH , especially in nonage .

目的：制备尼莫地平前体脂质体片剂（ProliposomeTablet，PT），考察其体外的释放特性。

AIM : To prepare the proliposome tablets ( PTs ) con taining nimodipine and to investigate the release behavior of drug from PT .