核酸适配体

CdSe量子点大的表面积促进了电化学信号，另外CdSe量子点的离子中心对扩大电化学信号可能也起到一个很大的作用，离子浓度越高就会吸附更多的核酸适配体从而产生更强的信号。

CdSe QDs improved the electrochemical signal because of their larger surface area and ion centers of CdSe QDs may also had a major role on amplifying the signal . The higher ion concentration caused more combination of aptamer which caused larger signal .

核酸适配体的特异性识别可以与单克隆抗体相媲美，同时相对于传统的抗体又具有特殊的优越性。

The specific recognition of the aptamer can be comparable with the monoclonal antibody technology , and has special advantages compared to conventional antibodies .

基于核酸适配体-质粒DNA复合物信号放大的荧光免疫传感技术

A New Fluorescence Immunosensing Method Based on Aptamer-plasmid Complex Amplification

核酸适配体类抗HIV-1药物的研究进展

Advances in Research on the Aptamers anti-HIV Drugs

用牛血清白蛋白、干酪素和人免疫球蛋白G代替凝血酶做了干扰试验，结果表明该核酸适配体传感器对凝血酶具有良好的特异性、稳定性及再现性能。

The control experiment was also carried out by using BSA , casein and IgG in the absence of thrombin . The results showed that the aptasensor had good specificity , stability and reproducibility to the thrombin .

将核酸适配体固定在水溶性CdSe修饰的玻碳电极上，构建了一种灵敏的核酸适配体传感器。

An easy and sensitive aptamer biosensor was developed by immobilizing the aptamer on water soluble CdSe quantum dots ( QDs ) modified on top of the glassy carbon electrode ( GCE ) .

基于核酸适配体的新型荧光纳米生物传感器用于凝血酶的测定

Detection of Thrombin with a Novel Nano-biosensor Based on Aptamer Fluorescence

通过此法构建的核酸适配体生物传感器具有良好的稳定性、特异性、重现性以及准确性，这为构建核酸适配体生物传感器提供了一个良好的平台。

This constructed biosensor also had a good stability , specificity , reproducibility and accuracy which could provide a promising platform for fabrication of aptamer based biosensors . 2 .

目前，基于核酸适配体的蛋白质检测技术发展迅速，涵盖电化学方法、比色法、荧光检测法、晶体石英微天平方法等，相关科学技术也正在快速发展。

At present , the protein detection technology based on aptamer has been developed rapidly , covering the areas of electrochemical methods , colorimetry , fluorescence detection methods and crystal quartz microbalance methods .

而且，该核酸适配体传感器可被用来进行实际样品的检测，获得的结果与用荧光法测得的结果相一致，为构建核酸适配体传感器提供了一个良好的平台。

Moreover , the aptasensor could be used for detection of real sample with consistent results in comparison with those obtained by fluorescence method which could provide a promising platform for fabrication of aptamer based biosensors . 3 .

核酸适配体因其自身的高特异性、高亲和力、易于修饰和功能化、成本低廉等一系列的优点，而成为化学、生物医学、材料科学等领域的研究热点之一，从而被广泛的研究应用。

The aptamer has a number of advantages such as high specificity , affinity , easier modification and functionalization , low cost and so on , it would be widely reached and used in chemistry , biomedical and material science , and becomes one of the research hotspots .