知母

本研究分别从化学和药效学两方面对知母抗龙胆斑枯病病原菌的活性部位进行筛选，最终确定了知母总皂菅类成分是高效的抗菌活性部位，其最低抑菌浓度为0.02g/ml。

Have been completed . The total saponins of Rhizoma anemarrhenae . were proved to be the best active antifungal parts , and the minimum inhibitory concentration was 0.02g/ml .

知母聚糖降糖作用及其机理研究

Study on the hypoglycemic effect and mechanism of Rhizoma anemarrhenae polysaccharide

知母N、P、K配方施肥效应的研究

Studies on the effect of N , P , K application in Anemarrhena asphodeloides

知母宁对老化红细胞CR1活性及脂质过氧化物水平的影响

Effect of Chimonin on activity of CR_1 and LPO level of ageing erythrocytes

用转染m2胆碱受体基因的CHO细胞观察知母皂甙元的作用

The Regulation Effect of Sarsasapogenin on M_2 Receptor Density in CHO m2 Cell

草果知母汤对戊四唑慢性诱导癫痫模型大鼠脑内海马区凋亡调控因子p53蛋白表达的影响

Influence of Tsaoko-Anemarrhenae Decoction on p53 protein expression in hippocampus of rat models with epilepsia chronically induced by pentylenetetrazol

新鲜黄山药中C（27）甾体皂苷的化学成分的研究知母根茎中含大量甾体皂苷，现代药理研究表明知母皂苷及皂苷元为其主要活性成分。

Isolation and Identification of Steroid Saponins from the Fresh Rhizomes of Dioscorea Panthaica There are plenty of Steroid saponin in the root and stem of Anemarrhena asphodeloides Bge .

知母宁（Chinonin）对辐照DNA电子自旋转移的初步研究

The study of electron spin transfer from γ - irradiated DNA to Chinonin

结论知母总皂苷在大鼠体内经吸收转化后可抑制大鼠脑皮质AchE活性。

CONCLUSION SAaB can inhibit the activity of AchE after the absorption and transformation in vivo .

方法：采用MTT比色法测定知母宁对Vero细胞的毒性作用。

Method : The toxicity of chinonin on Vero cell was measured by MTT colorimetry .

目的研究知母总皂苷（totaltimosaponin，TT）的抗抑郁作用及其机制。

Objective To study the antidepressant effect of total timosaponin ( TT ) and its mechanism .

知母皂苷B对大鼠海马注射β-AP（25~35）致tau蛋白磷酸化的影响

Effects of Saponin B from Anemarrhena asphodeloides Bunge on tau hyperphosphorylation induced by beta - amyloid peptide ( 25 - 35 ) in rats

建立了265nm知母HPLC指纹图谱，以芒果苷峰作参照物，确定21个共有指纹峰。

The HPLC-FPs of Rhizoma anemarrhenae were established with 21 common peaks under 265 nm and the peak of Mangiferin was selected as the reference peak .

石膏知母人参配伍对人参皂苷Rb1含量变化的影响

Study on the Contents of Ginsenoside Rb_1 in Different Groups of Rhizoma Anemarrhenae and Radix Ginseng Compatible with Gypsum Fibrosum

CREB在知母皂苷元调节M1受体中的作用

Role of CREB in the regulation of muscarinic m_1 receptor by sarsasapogenin during cell aging

淫羊藿协同作用明显，淫羊藿与巴戟天合煎促进颗粒细胞分泌E2的作用大于分煎。知母对颗粒细胞分泌E2有一定的抑制作用。

Zhi Mu inhibited the secretion of E_2 . The separated decoction of Ying Yang Huo and Ba Ji Tian has slight stimulating effect on the E_2 secretion , compared with their mixed decoction .

结果表明：影响知母叶片数、须根数、根茎鲜重和叶片鲜重的主要因子是N肥，其次是K肥和P肥；

The results are as follows : N fertilizer was the major factor on the number of leaf , fibrous root , and the fresh weight of root and leaf , K fertilizer and P fertilizer then followed .

以中药知母为研究材料，使用浸提、超滤、CMC纤维素柱层析等方法，分离得到α-葡萄糖苷酶抑制剂。

With Anemarrhena asphodeloides Bunge as the study material , we have separated α Glucosidase inhibitor through extraction , ultrafiltration and CMC ion exchange chromatography .

结论：知母宁有抗乙肝病毒的作用，其机制可能与抑制HBV-DNA的复制有关。

Conclusion : Chinonin has the effect of decreasing the secretion of HBeAg , which maybe relate to restraining the duplication of HBV-DNA .

目的：考察知母总多糖（TPA）的抗炎作用，并初步探讨其作用机制。

Objective : To investigate the anti inflammatory activity of total polysaccharides of Anemarrhena asphodeloides Bunge ( TPA ) and discuss the mechanism roughly .

目的探讨知母总皂苷（totaltimesaponin，TT）抗实验性抑郁作用并分析其可能的作用机制。

Objective To study the antidepressant effects of total timesaponin ( TT ) on experimental depression models and analyze the mechanism of this action .

方法采用HPLC法比较不同溶剂、不同提取方法从知母中提取出的芒果苷的含量及知母毛皮肉中芒果苷含量。

Methods Use HPLC to compare the content of mangiferin exacted from different solvents and by different extracting method and then compare the content of mangiferin in hair skin and meat of Anemarrhena asphodeloides Bge .

结果：PTZ点燃癫痫大鼠脑内CFos、CJUN基因表达明显增强，草果知母汤能明显阻断其表达，并显示出良好的抗痫作用。

Results : The c fos , c jun gene expression was obviously increased , TAD could effectively block the gene expression of c fos , c jun , showing better antiepileptic effect .

肺组织炎性反应明显减轻，与地塞米松组接近。知母宁组血清NO及BALF中ET-1水平均较哮喘组显著下降，也与地塞米松组相似。

The NO in serum and ET-1 of BALF in chinonin group were lower than those in model group , which was similar to the dexamethasone group .

为从大量中草药及其化学成份中筛选有效低毒的醛糖还原酶抑制剂（ARI），建立了猪晶状体AR的测定方法，其研究了知母等40种中药水提取液对AR的抑制作用。

For screening aldose reductase inhibitors ( ARI ) from traditional medicinal herbs , the assay method of pig lens AR was established and 40 traditional medicinal herbs were screened .

结果与结论：体外血小板聚集模型研究证明，知母皂苷AⅢ可以抑制由ADP、胶原和凝血酶诱导的大鼠血小板的聚集，并呈剂量效应。

Results and Conclusion : Timosaponin-A ⅲ could inhibit rat platelet aggregation induced by ADP , collagen or thrombin in a dose-dependent manner in vitro .

在大鼠20月龄时开始连续喂服知母或ZMS4个月后，知母组皮质和海马的灰度显著高于老年对照组24%和19%（P值＜0.05）。

Parallel experiments revealed that when aged rats were treated for 4 months by daily oral administration of ZM starting from 20 months old . the M-cholinergic receptor densities of cortex and hippocampus were significantly higher than untreated aged rats ( P < 0 . 05 ) .

采用改良的TBA分光光度法研究知母宁、槲皮素与单宁酸对辐射所致小鼠组织中LPO含量升高的抑制作用。

The inhibiting effects of Chinonin , Quercetin and Tannic Acid on the lipid oxidation induced by radiation exposure were investigated by means of a modified TBA spectrophotometry .

结论ZMS能上调脑M2受体，这很可能是知母改善脑学习记忆功能的重要因素之一。

Conclusions ZMS has the ability of up regulating M 2 receptor and this may be an important factor for the improvement of learning and memory by ZMS .

方法：采用人流感病毒A型（H1N1）滴鼻感染小鼠，以利巴韦林作为阳性对照药，对知母宁抗病毒活性进行评价。

Method : The mice were infected with human influenza A virus ( H1N1 ) by nasal drip . The antiviral capacity of chinonin was evaluated by using ribavirin as the positive reference drug .