砷中毒

目的探讨砷中毒的致癌机理及寻找灵敏、实用的DNA损伤监测指标。

Objective In order to research arseniasis 's mechanism on causing poisoning , especially resulting in skin carcinoma and search sensitive , practical monitoring index of DNA damage .

燃煤型砷中毒皮肤病变中P16、P21~（WAF1/CIP1）、cyClinD1蛋白的表达及意义

The expression of P16 、 P21 ~ ( WAF1 / CIP1 ) and Cyclin D1 proteins in skin of patients with arseniasis caused by coal burning and their significance

维生素C、锌制剂拮抗慢性砷中毒的实验研究

Experimental Study on Antagonistic Effects of Vitamin C and Zinc Agent on Chronic Arsenic

用微量全血彗星试验观察砷中毒病区人群DNA损伤

DNA damage of drop whole blood specimen from endemic arsenism population by comet assay

用mRNA差异显示PCR技术筛查慢性砷中毒相关基因片段

Screening of arsenism related gene fragments by mRNA differential display PCR method

慢性砷中毒自觉症状和皮肤改变影响因素的Logistic分析

Logistic analysis of dangerous factors to subjective symptoms and skin involvements of endemic arsenic disease

结论慢性砷中毒能够导致肝线粒体细胞色素C氧化酶和ATP酶的活性下降。

Conclusion The chronic arsenism could result in the activity decline of the mitochondria cytochrome C oxidase and ATPase .

金属硫蛋白-1与p53基因在燃煤型砷中毒患者口腔黏膜脱落细胞中的表达

Expression of the MT and p53 genes in buccal mucous membrane exfoliated cells in coal-burning arsenism

目的研究BCL-2基因在燃煤型砷中毒致皮肤恶性病变过程中的作用。

Objective To study the effect of BCL-2 gene on skin carcinogensis due to arseniasis caused by coal-burning .

结果首次建立了内蒙古砷中毒病区水砷与砷中毒关系的人工神经网络BP模型。

Results The model of artificial neural network of the relationship between arsenic in water and arseniasis in Inner Mongolia was established firstly .

因此，砷中毒时血液中的砷透过毛细血管后应首先进入AC。

Therefore , the arsenic poisoning of arsenic in the blood through the capillaries to be the first to enter after the astrocytes .

用SCGE法检测燃煤污染型砷中毒患者血细胞DNA的损伤作用

Detection of DNA damage in blood cells of the patients of coal burnt arsenism by SCGE

目的了解燃煤型砷中毒患者红细胞（RBC）免疫功能与脂质过氧化关系。

Objective To study the relationship between RBC immunity and lipid peroxidation of arsenism patient .

Rb和p53蛋白在燃煤型砷中毒患者皮损中表达的研究

Study on the expression of Rb and p53 protein in lesions of patients with coal arsenic toxin

As、Cu、K、Se的变化与砷中毒的典型症状有一定相关性；

The relationship between the typical symptoms of arsenism and the levels of As , Cu , K and Se in hair were found .

目的：探讨砷中毒角化皮损中肿瘤相关蛋白P53、Bcl-2、PCNA的表达及相互关系。

Objective : To investigate the expression of tumor related protein P53 , Bcl 2 , PCNA in arsenical keratosis skin tissues .

结论燃煤污染型砷中毒患者的膳食结构不合理，维生素B2、钙、硒等营养素摄入不足。

Conclusions The dietary pattern of sufferers of arsenic poisoning caused by burning coal pollution is unreasonable , resulting in an insufficient intake of nutrients such as Vitamin B_2 , calcium and selenium .

谷胱甘肽硫转移酶M1和T1基因多态性与燃煤型砷中毒发病的关系

Relationship between genetic polymorphisms in glutathione S-transferase M1 , T1 and arsenic poisoning caused by coal-burning

急性砷中毒小鼠血清中NO、GSH、MDA及总抗氧化能力的实验研究

Experimental study on nitric oxide , glutathione , maleic dialdehyde and total anti-oxidize ability in serum of mice with acute arsenic poisoning

目的探讨慢性砷中毒患者自觉症状、皮肤色素异常及过度角化的影响因素。方法选择山西大同地区山阴县黑疙瘩乡大营村进行调查问卷及体检，结果进行单因素及多因素Logistic逐步回归分析。

The investigation in an endemic arsenic disease area and logistic analysis were made to explore the dangerous factors to subjective symptoms , abnormal skin pigmentation and keratosis .

目的分析燃煤型砷中毒患者皮肤癌变过程中增殖细胞核抗原（PCNA）、B-淋巴细胞瘤/白血病-2抗凋亡蛋白（BCL-2）和突变型P53基因蛋白（P53mt）的表达情况及相关性。

Objective To analyze cooperative expressions of PCNA , BCL 2 and P53 mt proteins in patients ' skin with arseniasis due to coal burning .

MMP-3和TIMP-3在燃煤型砷中毒患者血细胞中的表达

Expression of MMP-3 and TIMP-3 gene in the patients suffered from coal-burning arsenism

结果砷中毒患者的膳食结构为典型的植物型，维生素B2、钙和硒的每日摄入量分圳仅占推荐量标准的38.57%、28.21%和54.28%。

The amounts of their daily intake of Vitamin B_2 , calcium and selenium were lower than the recommended national dietary standard , only making up 38.57 % , 28.21 % and 54.28 % of the recommended standard amounts respectively .

结论MMP-3、TIMP-3基因在燃煤型砷中毒代谢中发挥了重要的调控作用。

Conclusions MMP-3 and TIMP-3 play a regulating role in the metabolism of coal-burning arsenism .

PCR-SSCP及克隆测序法研究燃煤型砷中毒患者p53基因突变与皮肤癌的关系

A Study on the Relationship between the Mutation of p53 Gene and Skin Cancer in Patients with Arsenism Caused by Coal-burning Using PCR-SSCP , Cloning and Sequencing

Pt-Pd催化剂砷中毒原因的初步研究

Study of arsine poisoning on hydrogen-removal catalysts

方法：采用生物化学法检测燃煤型砷中毒患者血清中TP，ALB含量和CHE活性。

Methods : Biochemical methods were used to detect the contents of TP , ALB and the activity of CHE in the serum of arsenism patients .

结果发现：砷中毒患者末稍感觉异常以痛觉、温度觉、压觉减退最为明显，与其对照对比有显著性差异（P＜0.05%）；

The result showed that the arsenic poisoning patients had got abnormal distal sensation with obvious features of hypalgesia , abatement of temperature sensation with obvious of hypalgesia , abatement of temperature sensation and pressure abatement , which had great difference with the control ( P < 0.05 );

目的探讨急性砷中毒小鼠血清中一氧化氮（NO）、还原型谷胱甘肽（GSH）、丙二醛（MDA）及总抗氧化能力的变化，及其在砷中毒发病机制中的作用。

Objective To clarify the variety and the significance of nitric oxide ( NO ), glutathione ( GSH ), maleic dialdehyde ( MDA ) and total anti-oxidize ability in serum of mice with acute arsenic poisoning .

方法对燃煤型砷中毒患者体内抗氧化物质超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、巯基（-SH）以及脂质过氧化代谢产物丙二醛（MDA）的含量进行了测定和分析。

Methods The activity of superoxide dismutase ( SOD ), glutathione peroxidase ( GSH Px ), the contents of hydrosulfide group ( SH ) and malondialdehyde ( MDA ) in the blood of patients were measured and analysed .